High-tech Research Research Articles

War and Sanctions. Some Economic and Political Lessons to be Learned From Materialist Anthropology

Abstract The political field seems to prefer the intellectual resources offered by Political Sciences and Economic Sciences because they fit well into the habits created by the daily practice of power. Assuming that it is not just about self-censorship, the current perspective offered by these scientific fields has some blind spots, and risks legitimizing an unfounded optimism regarding the effectiveness of the means used in the crisis generated by the Russian-Ukrainian war. That is why I consider the perspective offered by materialist anthropology to be very useful for describing the complexity of the power relations, and for a fine-tuning of what-is-at-stake. This perspective, which looks at long-term trends, can highlight the differences between imagined power (given by habits, abstractions and the assumption of continuities) and real power (given by the technologies and resources that matter, real scarcity and international competition). I concluded that the imagined power relations of today are a survival of the real power relations from the near past (when the GDP in the Western world was correlated with powerful local manufacturing and a complete dominance in high-tech research). Our mindset, habits and biases created a blind-spot that made difficult to grasp the complexity of the situation and to react accordingly.

Multispiral computed tomography upper-level arteriovenous conflicts (abdominal cavity and retroperitoneal space)

Introduction. Continuous improvement and increased availability of high-tech research methods, such as computed X-ray tomography (CT) and magnetic resonance imaging (MRI) with contrast enhancement, qualitatively change the diagnostic search for combined vascular pathology, including when conducting studies of other organs and systems, even in the absence of any clinical manifestations.The purpose of the study: to evaluate the possibilities and determine the indications for CT diagnosis of arteriovenous conflicts of the abdominal cavity, retroperitoneal space.Research objectives: to determine CT parameters and the algorithm of CT analysis of upper-level arteriovenous conflicts in modern radiation and urological aspects.Materials and methods. The study included 34 patients with arteriovenous conflicts of the abdominal cavity and retroperitoneal space detected by computer X-ray tomography. The average age of patients is 39±11.0 years; the number of male patients is 19 (55.9%), female — 15 (44.1%). Children’s patients accounted for 23.5% (8 people; average age 11±7 years). The preoperative diagnostic algorithm included a clinical examination, ultrasound diagnostics, a comprehensive study of laboratory parameters, CT-arterio/venography.The results of the study. Among the upper—level arteriovenous conflicts, superior mesenteric artery syndrome prevailed — it was observed in 23 patients (67.6%), of which aortomesenteric duodenal compression (Wilkie syndrome) was detected in 12 patients (52.2%); aortomesenteric venous compression (Nutcracker syndrome) — in 11 patients (47.8%). Among children’s patients, aortomesenteric tweezers prevailed (5 patients — 62.5%). A combination of upper-level syndromes was detected in 6 patients (17.6%). Compression syndrome of the left renal vein (aortovertebral venous compression, posterior nutcracker syndrome), or Nutcracker syndrome was detected in 11 patients (32.4%), which in all cases (100%) was a «random finding» of CT diagnostics.Conclusions. It is recommended to perform CT-, MR-studies with contrast enhancement (in angiography mode) in patients with a suspected diagnosis of arteriovenous conflict with the expansion of the scanning zone to the level of the abdominal cavity, retroperitoneal space and pelvis in order to exclude combined multi-level vascular pathology. Mandatory for radiation analysis are the magnitude of the aortomesenteric angle, the magnitude of the aortomesenteric distance for the left renal artery, the magnitude of the aortovertebral distance for the left renal artery, the magnitude of the aortomesenteric distance for the duodenum; analysis of concomitant variant vascular pathology at the levels studied.

Resolution of the Council of Experts “Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics”

The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The criteria of the microbiological norm for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification.
 Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of Saccharomyces boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence.
 This article is a reprint. Primary Publication: Gorelov AV, Zakharova IN, Khavkin AI, Kafarskaya LI, Usenko DV, Belmer SV, Kornienko EA, Privorotsky VF, Krasnov VV, Kondyurina EG, Panfilova VN, Tkhakushinova NKh, Plaksina AN, Rychkova OA, Pechkurov DV, Nizhevich AA, Fayzullina RA, Yablokova EA. Resolution of the Council of Experts Dysbiosis. Immediate and long-term consequences of microbiome disorders and options for their correction with probiotics. Vopr. prakt. pediatr. (Clinical Practice in Pediatrics). 2022;17(1):213221 (in Russian). DOI: 10.20953/1817-7646-2022-1-213-221. With the permission of the copyright holder. Published with reductions.

Strategies to Engage Systematically Marginalized Youth and Their Families in Research Using High-Tech Methods.

The purpose of this study was to identify facilitators and barriers for engaging youth and families from a historically and systematically marginalized community in high-tech research. Adapting community-based participatory research principles, 4 focus groups were conducted with 13 youth and 12 parents. Using codebook thematic analysis, 5 facilitator themes (develop skills, ensure health, build understanding, promote safety, and help others, youth-initiated interest) and 4 barrier themes (anxiety and fear, skepticism, confusion, and unfamiliar/unknown experience) were identified. Youth and parent responses informed proposed guidelines for recruiting and engaging families in research using high-tech methods, particularly those from historically and systematically marginalized communities.

PROCALCITONIN DETERMINATION IN ONCOLOGY – RESULTS AND PROSPECTS: A LITERATURE REVIEW

Relevance: Modern requirements for laboratory diagnostics of complicated courses of diseases provide for using particular and hightech research methods like determining the level of procalcitonin (PCT). The PCT level increases only with the generalization of a bacterial
 infection and reflects the degree of abstraction. Of practical value are an increase in the PCT level and the degree of such increase, a progressive increase, or a long-term (more than 3-5 days) high level. The assessment of this data over time, in combination with the changes
 in other clinical and laboratory parameters, allows for timely diagnosis and prediction of the outcome of the disease.
 The study aimed to assess the feasibility of the PCT level dynamic control for timely diagnosis of the overlay or generalization of an
 infectious process in the form of septic complications in cancer patients.
 Methods: A thematic search was carried out by keywords in the journal Malignant Tumors and Cochrane, PubMed, Oncology.ru,
 elibrary.ru, Medscape, and NCBI databases and libraries.
 We analyzed the results of studies of changes in PCT dynamics in oncological patients who developed and generalized a nonspecific
 infectious process that proceeded in the form of septic complications.
 Results: Various research papers have confirmed the need to determine the PCT level and its inclusion in the diagnostic algorithms.
 The reliability and significance of these studies correspond to the highest levels of evidence-based medicine.
 PCT shows its high specificity in identifying the infectious component compared to other less informative indicators in oncological
 pathologies, such as the level of leukocytosis, CRP, and others.
 In some tumor processes, the initial level of PCT may be higher than the average (0.5 ng/l). Still, dynamic control will show the effectiveness of the therapeutic measures taken and the direction of development of the infectious process.
 The frequency and intervals of determining the PCT level are of particular importance. In some instances, if an infectious component
 is suspected in risk groups, the PCT level determination could be included in the initial examination algorithm.
 Conclusion: Despite the ambiguity of the PCT study results in oncological practice, the determination of systemic inflammation biomarkers in complex antitumor therapy will allow timely setting of indications for prescribing or intensifying antibiotic treatment, predicting
 the duration, and monitoring its effectiveness in oncological patients.

Training of academic lawyers for implementation of high-tech research projects (“Digital Law”, “Megascience” and “Lex genetica” projects case study)

The legal profession has both conservative and innovative features. On the one hand, present-day lawyers are the heirs of the centuries-old tradition of global jurisprudence. On the other hand, the technological challenges of the external environment inevitably transform not only the legal map of the world, but also the peculiarities of training for modern legal professionals. The article deals with the main transformational paradigms of legal professionals training, using the example of three high-tech spheres of public life – genetics, digital economy and mega-science installations development. Academic lawyers (legal scholars) are in many ways at the forefront of the present-day jurisprudence, defining both the present and the future of the global legal space. Their training takes longer than the standard education course for lawyers. The data of the Russian legal system and the legal systems of other countries, as well as international legal practice, served as the empirical basis for the research.

ГОСУДАРСТВЕННОЕ РЕГУЛИРОВАНИЕ ИННОВАЦИОННОГО РАЗВИТИЯ РЕГИОНА В КОНТЕКСТЕ РЕАЛИЗАЦИИ ПРИНЦИПОВ «ЗЕЛЕНОЙ ЭКОНОМИКИ»

Annotation. Innovative economic development requires the use of high-tech technologies and qualitatively new approaches to the conditions for ensuring sustainable economic development. The transformation of the economy actualizes the issues of developing conceptual aspects of the development of regions and the state as a whole, the formation of mechanisms of state regulation and support. The study of trends in the development of the world economy and factors affecting the sustainability of economic development contributes to the development of effective mechanisms that promote economic growth and development. The construction of a national innovation system requires an integrated approach that takes into account the achievements of the world economy in the development of knowledge-intensive and innovative economic sectors, ensuring the implementation of the principles of a «green economy» focused on the careful use of resources and reasonable consumption. The innovative vector of development of the national economy is impossible without a comprehensive mechanism of support of public authorities. The innovative orientation of the economy implies a high capital intensity, which leads to the emergence of financial deficits, the disclosure of which is impossible without effective regulators. Economic sanctions, the withdrawal of foreign capital from the country exacerbate the current problems of limited resources for technological and industrial breakthroughs, but at the same time create opportunities to fill the vacated niches with domestic high-tech and innovative projects that contribute to sectoral renewal and the national economy reaching a new level. Innovative developments are designed to provide priority sectors of the economy with sustainable competitive advantages both in the domestic market and in world markets. The need for pharmaceutical, technological and energy innovations is growing. The state is focused on supporting fundamental, high–tech research – space, IT technologies, bioengineering, etc. However, innovative activity is necessary in all sectors of the domestic economy, which is acutely felt during the period of tough sanctions policy against Russia. The article raises the issues of state stimulation of innovation activity of economic entities as factors contributing to the sustainable economic development of regions. The analysis of the factors contributing to the growth of innovation is carried out, the need for state influence on the innovation processes of the region is substantiated.

Резолюция Совета экспертов «Дисбиоз. Ближайшие и отдаленные последствия нарушения микробиома и варианты их коррекции с помощью пробиотиков»

The appearance of new high-tech microbiological research methods has significantly changed the understanding of the human microbiome. The purpose of the meeting of the Council of Experts "Dysbiosis. The immediate and long-term consequences of microbiome disorders and options for their correction with probiotics" was the definition of modern positions about possible methods of studying the intestinal microbiome, the possibilities of correcting dysbiosis, the use of Saccharomyces Boulardii CNCM I-745 to correct microbiome disorders in various clinical situations. The microbiota of the large intestine is represented by more than 1000 species of 7 different phyla of the Bacteriae domain, up to 160 numerically prevailing species are detected in one individual. The criteria of the microbiological "norm" for the intestinal microbiome have not been definitively established. To study the microbiome, a set of methods is used that combine cultural and molecular genetic methods that complement each other. Currently, none of the methods is widely available in clinical practice. To study the functional state of the intestinal microbiota, the most accessible is breath testing. Currently, there are no clinical markers of dysbiosis, and laboratory markers of dysbiosis require modification. There is an insignificant spectrum of diseases with such markers: acute intestinal infections, antibiotic-associated C. difficile-diarrhea, IBD, IBS. Probiotics can provide restoration of the intestinal microbiota. The effectiveness and safety of the use of S. boulardii CNCM I-745 for this purpose has been proven. In the case of acute intestinal infection, antibiotic-associated diarrhea, and the consequences of HP infection eradication, studies have a high level of evidence, and the use of Sb CNCM I-745 for treating IBS and IBD in children is promising.

The Relationship between the Improvement of Foreign University Leadership and the Modernization of University Governance

Universities are leading, leading, basic, and monopolistic in terms of high-tech knowledge production and productivity transformation, knowledge innovation talents and high-tech research and development talents, which determine that universities have become a national economy. A productivity element with dynamic value that is indispensable for take-off, social progress and its stability and sustainable development. On the basis of discussing "why the modernization of university governance capabilities is so important" and clarifying the "relationship between university leadership and university governance capabilities", the paper starts with "ideological power", "organizational power", "Decision-making power", "institutional power", and "resource power". The 7 aspects of "cultural power" and "principal power" construct and interpret the university leadership element model.

Cloud-based systems of open science in educational institutions

In the modern educational and research university environment there are new models of organization of investigations, as well as educational and scientific activities, based on innovative technological solutions and pedagogical approaches to open science. Issues of setting up cloud-based open science tools and services for users, forming open science systems within the educational and scientific environment of the educational institution in order to maximize the pedagogical potential of their use, improving learning and research outcomes, and improving the organization of research and educational activities are the subject of the article. Conceptual aspects of formation and development of high-tech learning and research environment of educational institution with the use of cloud-oriented systems of open science, as well as organization of access to electronic resources and services to support investigative activities based on cloud computing and research infrastructures are outlined.

Issue of crypto currency as a means of achieving scientific and technological progress

The distribution of federal budget funds for 2021-2023 years shows a tendency to reduce the cost of maintaining high-tech innovative research. The problem of attracting funds to innovative activities is becoming one of the main areas of activity. The subject of the study is the system of financing, including through investment mechanisms, research and development activities in the conduct of high-tech research, design developments. The purpose of the study is to develop a methodology for financing research and development activities through the institution of ICO projects. The following methods are used: empirical methods of comparison, description, interpretation; theoretical methods of formal and dialectical logic; private-scientific methods: legal-dogmatic and method of interpretation of legal norms. The analysis of the existing system of financing high-tech research and design development is carried out, and the main problems of the existing system of implementing state space programs are highlighted. The features of the issue of crypto currency through ICO projects for the implementation of scientific research are disclosed. This study proposes a model for the development of economic relations between the private sector involved in the implementation of domestic scientific research and the customer, represented by the Government of the Russian Federation. The presented model of interaction of participants of the domestic market of space technologies is aimed at creating favorable conditions for the development of domestic cosmonautics, conducting research and development activities. The proposed model of issuing crypto currency through ICO projects for the implementation of scientific research will increase the funding of domestic research and development activities. The stabilization of investment processes that contribute to long-term planning of investment returns will allow large financial flows of private investors to be poured into scientific and technical research. As a result, a planned increase in investment activity is expected, which allows launching innovative projects on a federal scale without attracting budget funds.

Does R&D investment moderate the relationship between the COVID-19 pandemic and firm performance in China’s high-tech industries? Based on DuPont components

ABSTRACT The spread of coronavirus disease 2019 (COVID-19) has had a significant impact on business and economies globally. This paper aims to investigate the impact of COVID-19 on firm performance in China’s high-tech industries. The population of this paper is 116 companies listed on the sci-tech innovation board (STAR market) of the Shanghai stock exchange. DuPont analysis is applied to measure firm performance including return on equity (ROE), return on assets (ROA), asset turnover ratio (ATO), and profit margin. The empirical results show that the COVID-19 pandemic has a significant and negative impact on ROE, ROA, and ATO in high-tech industries, and research and development (R&D) investment has a moderating role in the relationship between the COVID-19 pandemic and firm performance. The findings may play a guiding role for corporate managers and policymakers to overcome this formidable crisis in the era of COVID-19.

HIGHER EDUCATION AND ECONOMIC GROWTH: AN EMPIRICAL STUDY OF PAKISTAN

Generally, Education is considered as human capital which is contributing positively to economic prosperity and growth. The research paper attempts to identify a relationship between different disciplines of higher education and economic development of Pakistan for the period of 1990-2017 using the Cobb-Douglas production function. The application of ordinary least square methodology examined the long-run relationship between higher education and Pakistan’s economic development. The empirical study found that in the long-run higher education has strong impact on economic growth of Pakistan. Seven academic disciplines are selected to observe the impact of educational categorization i.e. Medical, Engineering, law, commerce, home economics, Education, and Agriculture. Estimated results revealed a positive and significant impact of getting higher education on Pakistan’s economic growth where the role of engineering and medical sciences was found prominent among all of the selected disciplines with respect to economic development. The findings of the study validate the assumption that human capital and economic growth are strongly correlated in Pakistan in the long run. However, there is a dire need to focus on research and development to enable the country to face competitiveness in the contemporary world and to adopt to the robust technological innovations. Research and Development institutions in Pakistan should pay attention on high-tech and scientific research so as to expedite economic development in the country.

Visual Quality Analysis of Educational Institutions and Their Surroundings: A Case Study of Ataturk University, Erzurum, Turkey

The study aimed to analyze the visual quality of the Educational Institutions and their Surroundings (EITS) in the campus of Ataturk University in Erzurum city of Turkey. Visual Quality Analysis Questionnaire was applied to 74 students studying at the Faculty of Architecture and Design. The questionnaire consisted of 21 EITS. Results were analyzed using Variance and Duncan multiple comparison. It was determined that Faculty of Fishery (EITS13) had the highest visual quality score (3.243), followed by Agriculture Faculty (EITS1: 3.134) and the Divine Faculty (EITS2: 2.906). The Faculty of Veterinary Medicine had the lowest visual quality score (EITS11: 2.165), followed by High-Tech Research Centre (EITS20: 2.243) and Faculty of Law (EITS16: 2.315). Statistically significant relationship was found between the department of the students and the scores they gave to Sports Science Faculty (EITS1), Education Faculty (EITS4), Faculty of Medicine (EITS10), Faculty of Veterinary Medicine (EITS11), Faculty of Fine Arts and Tourism (EITS15), and Rectorate Building (EITS19). Among the Visual Quality Criteria (VQC) of EITS, accessibility to the structure (VQC12) was the most effective criterion (2.927, p<0.05). This study recommended the correction of design deficiencies to compensate for the lack of visual quality of new buildings or to improve the entire landscape of the campus.

Creation of new jobs and creativity of the urban space

Over the last decades industries, that affect human capital development, have stepped into the spotlight. Engineering companies, creative and service enterprises have assumed a crucial role in the urban economy and its potential. As for large urban agglomerations, new forms of production and creative class mobilization represent the key objectives due to the reduction or liquidation of the majority of industrial urban enterprises.
 Urban planning as a science is responsive to economic changes. The paradigm of functional zoning has been replaced by theories based on land use intensity, business and cultural activities of population. Hence, the idea is to ensure the polyfunctional operation of industrial, high-tech research companies in residential areas and to relocate housing to areas occupied by old industrial enterprises.
 In this work, the co-authors analyze the phenomenon of the location value in a modern city, regularities that govern the choice of locations for new enterprises; they also suggest approaches to the zoning of urban areas depending on their potential ability to develop new types of industrial production.

Protection against vibroacoustic impacts on example of high-tech research centre

In this paper the elastic support of building structures is discussed as one of the advanced technical solutions for protecting buildings against vibrations and structure-borne noise. Two of several possible variants of solutions are described on the example of special-purpose facility built in Cracow, Poland. The specificity of the building of the “Solaris” research centre is the use of high-tech mea- surement technologies and vibration-sensitive equipment. Then a restrictive criterion of the permissible level of vibroacoustic impacts on the building was set at the early design stage. To ensure effective reduction of vibrations transmitted through the ground, the necessary activities are described. The protection method by using appropriate mitigation measures (anti-vibration materials) is shown. The presented example draws attention to the problem of a rational and comprehensive approach to the subject of protection against vibrations, which is part of the concept of sustainable development in civil engineering.

Cost-Effectiveness of Risk-Stratified Endoscopic Screening for Esophageal Cancer in High-Risk Areas of China: A Modeling Study

Background: Risk-stratified endoscopic screening (RSES), which provides endoscopies to individuals at high risk for esophageal cancer (EC), has been suggested to improve screening efficiency. We aimed to assess the cost-effectiveness of RSES and identify the optimal thresholds for EC screening in high-risk areas of China. Methods: From a healthcare system perspective, a Markov model was constructed to compare the cost-effectiveness of 13 RSES strategies (under different threshold scores of EC risk), universal endoscopic screening strategy, and no screening. Six cohorts of 100 000 women and men with different start ages (40, 45, 50, 55, 60 and 65 years) with follow-up to age 77 years. The incremental cost-effectiveness ratio (ICER), i.e., the incremental cost per quality-adjusted life-years (QALYs) gained, was the primary outcome. Univariate and probabilistic sensitivity analyses were conducted. Findings: Compared with no screening, as the score threshold of the RSES was lowered, additionally gained QALYs increased, with 49−172 QALYs and 329−1258 QALYs gained from 40 years to 65 years. RSES in all age scenarios had ICERs less than 1×GDP per capita (US$10 276/QALY), and 11 RSES strategies with threshold scores of 3–13 had lower ICERs than universal endoscopic screening. Compared to universal endoscopic screening, which had the largest health gains than no screening, RSES with threshold scores of 8, 9, and 10 decreased cost by US$ 0‧35 0–47 million and reduced endoscopies by 7692–9943 with a slight decrease in QALYs. At a willingness-to-pay threshold of US$10 276/QALY, RSES (with threshold scores of 8 and 9) and universal endoscopic screening had a 43‧8–51‧7% and a 49‧6–67‧5% probability of being the most cost-effective at the age of <55 years and ≥ 55 years. Interpretation: RSES is cost-effective in high-risk areas of China. RSES with threshold scores of 8 would be recommended if EC screening was considered for residents aged 40–69 in high-risk areas of China. Funding Information: This work was supported by the Key Technologies Research and Development Program in China (2018YFC1313100), the National High-tech Research and Development Program (grant number: 201502001), the Beijing Science and Technology Planning Project [grant number: J200017], and the Sanming Project of Medicine in Shenzhen (grant number: SZSM201911015). Declaration of Interests: We declare that all authors have no conflicts of interest or financial interests to disclose.

Management of sustainable development of the regions of Kazakhstan: problems and solutions

The study presents the results of the implementation of the State Program for the Development of the Regions of the Republic of Kazakhstan until 2020. In the face of modern challenges, it becomes critically important to increase the self-sufficiency of the economy of the Republic of Kazakhstan on the basis of regional development. In order to comply with and take into account national interests, it will be important to launch the adopted State Program for the Development of Regions by 2025. State regulation of territorial development is aimed at disclosing the industrial potential of individual regions and territories of the Republic of Kazakhstan. Taking into account the processes of regionalization taking place in the economy, the prerequisites for the formation of a regional structure of industrial production are considered in the work. The results of the implementation of the State Program for 2015-2019 were considered and problematic issues requiring changes in regional policy were formulated. Based on the analysis, the authors presented a new approach to regional development, which will ensure macroeconomic stability based on high-tech industries (technology parks), educational and research clusters (corporations, universities and laboratories). To increase the efficiency of management of the territorial development of the Republic, systemic measures are

System Design of Network Data classification Based on Deep Packet Inspection

With the rapid development of the Internet, as an important method of network security protection, network data classification has become the focus of high-tech research. In order to efficiently process massive network data, filter irrelevant data packets, and resist malicious attacks, so as to ensure the safety and stability of network operating, based on the research of deep packet inspection (DPI) technology, a kind of network data classification system has been presented. This system is based on the architecture of field-programmable gate array (FPGA) and ternary content addressable memory (TCAM). Tests show that the system can meet actual requirements of network data classification.

Formation of Multi-Project Approach to Realization of Target Development Programs of High-Tech Research and Production Systems and Powerful Enterprises

Based on the study of the state of Ukrainian enterprises and peculiarities of the world's leading companies growth, the main tasks for improving quality of project and multi-project management of domestic enterprises modernization (improvement) and development of their high-tech production systems were identified. A modern model (standard) of turnkey formation and implementation of innovation and investment mechanism (projects and target programs) of continuous-cyclical process of creating science-intensive competitive products with a high level of added value and systems of its high-tech production at domestic enterprises was proposed by authors. In article was considered world management standards, the latest achievements of advanced science and technology, modern theory of strategic, multi-project, corporate and innovation and production management. The basic procedures and tools for the formation, organization and management of turnkey implementation of unique innovation and investment projects and targeted programs for the development of high-tech research and production systems and powerful enterprises in Ukraine were determined. The key steps and main stages of design and program activities to improve investment, innovation and production and economic mechanisms of the enterprise have been developed. A set of practical measures for effective program-targeted and project management of continuous innovation-economic and high-tech development of domestic products and their producers, covering all phases and stages of the life cycle of relevant programs and projects were proposed. Implementation of the proposed mechanisms and procedures of multi-project management of innovation and economic development will help increase the competitiveness of Ukrainian producers, ensure their faster transition to world standards of management and development, and ultimately – increase the welfare of Ukraine.