Multi-principal-element alloys (MPEAs) exhibit superior strength and good ductility. However, tribological properties of FeCrNi MPEAs remain unknown at nanoscale and complex environments. Here, we investigate the effects of scratching speed, depth, and temperature on microstructural and tribological characteristics of FeCrNi using molecular dynamics simulations combined with an elevated temperature tribological experiment. The scratching force experiences the increase stage, the undulated stage, and the stable stage due to chip formation. Compared to traditional alloy coatings, low force enhances the useful life. With increased speed, the friction coefficient decreases, agreeing with previous work. High speed impacting includes severe local plastic deformation, from dislocation to amorphization. As the scratching depth increases, the average scratch force and friction coefficient increases owing to material accumulation in front of the abrasive particles. The surface morphology and dislocation behavior are significantly different during the scratching process. In addition, we revealed a temperature-dependent friction mechanism. FeCrNi MPEAs have excellent wear resistance at an intermediate temperature, which is attributed to the high Cr content promoting the formation of the compact oxide layer. This work provides atomic-scale mechanistic insights into the tribological behavior of FeCrNi, and would be applied to the design of MPEAs with high performance.