Aircraft hydraulic brake system usually use pressure servo valve for anti-skid brake control. As pressure servo valve realizes the pressure closed loop by hydraulic feedback loop, this structure increased the complexity of the processing and manufacturing, restricted the pressure closed loop parameters adjustment, and increased the difficulty of debugging the system design. Pressure servo valve is expensive and difficult to process, poor ability to resist pollution. This paper proposed a slip ratio large closed loop aircraft anti-skid brake control method based on high-speed on-off valve, built the model of aircraft ground vertical taxiing and slip ratio large closed loop control algorithm in the MATLAB/SIMULINK, and built the model of aircraft hydraulic brake system based on on-off valve in the AMESim and a joint simulation was carried out. The simulation results show that the aircraft anti-skid brake control method based on high-speed on-off valve is feasible, and the on-off valve is cheap with strong ability to resist pollution, easy processing and manufacturing and so on, showing a good application prospect.