The ball screw for high speed machining center series which is a feed speed 100m/min is merchandised to cope with a demand for increasing the feed speed of machine tool. We realized the ball screw specifications such as ball diameter, ball center diameter are related for noise creation and the ball screw for high speed machining center series are controlled these factor to minimize the noise level. Recently, a demand for the noise reduction of the ball screw has been getting higher from the point of the environment countermeasure. This report is the result of the consideration and the examination of noise level and vibration of ball screws which are used in machine tool.