To reduce the resistance of high-speed displacement ships with Froude numbers (Fr) between 0.4 and 0.5, this paper proposes the installation of hydrofoils at the bow and stern of the ship. Firstly, starting from the bow wave, this paper proposes the installation of a flat plate appendage at the free surface of the ship’s bow to suppress the height of the bow wave and thus reduce the hull resistance. Taking the DTMB 5415 ship model as the research object, CFD calculation results show that installing a flat plate appendage at the free surface of the ship’s bow can effectively suppress the height of the bow wave, and the total resistance reduction ratio can reach 6.49% when Fr = 0.45. Then, the flat plate appendage was improved to a hydrofoil appendage, further reducing the hull resistance. As a result, the total resistance reduction rate can reach 9.15% at Fr = 0.45. Following this, hydrofoil appendages were installed simultaneously at the bow and stern. The drag reduction effect and mechanism were studied, and the results show that the hydrofoils at the bow and stern have a good drag reduction effect. Suppressing the bow and stern waves and improving the flow field are the main reasons for the drag reduction. Finally, the drag reduction effect of the hydrofoil appendages was verified through experiments, demonstrating its excellent drag reduction effect when Fr = 0.4–0.5 and a maximum total resistance reduction ratio of 14.552%.