You have accessJournal of UrologyKidney Cancer: Advanced II1 Apr 20101798 LOW SOCIOECONOMIC STATUS IS A PREDICTOR OF LOCALLY-ADVANCED RENAL CELL CARCINOMA: A POPULATION-BASED STUDY Giovanni Lughezzani, Lars Budaus, Rodolphe Thuret, Claudio Jeldres, Daniel Liberman, Shahrokh F. Shariat, Hugues Widmer, Philippe Arjane, Wassim Kassouf, Markus Graefen, Francesco Montorsi, Paul Perrotte, and Pierre I. Karakiewicz Giovanni LughezzaniGiovanni Lughezzani Milano, Italy More articles by this author , Lars BudausLars Budaus Hamburg, Germany More articles by this author , Rodolphe ThuretRodolphe Thuret Montpellier, France More articles by this author , Claudio JeldresClaudio Jeldres Montreal, Canada More articles by this author , Daniel LibermanDaniel Liberman Montreal, Canada More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat Montreal, Canada More articles by this author , Hugues WidmerHugues Widmer Montreal, Canada More articles by this author , Philippe ArjanePhilippe Arjane Montreal, Canada More articles by this author , Wassim KassoufWassim Kassouf Montreal, Canada More articles by this author , Markus GraefenMarkus Graefen Hamburg, Germany More articles by this author , Francesco MontorsiFrancesco Montorsi Milano, Italy More articles by this author , Paul PerrottePaul Perrotte Montreal, Canada More articles by this author , and Pierre I. KarakiewiczPierre I. Karakiewicz Montreal, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1722AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Low socioeconomic status (SES) is an established predictor of unfavorable outcomes in a large number of solid malignancies. We examined the effect of SES on the rate of locally-advanced stage (pT3-4 or pN1-2) in patients with non-metastatic (M0) renal cell carcinoma (RCC). METHODS Between 1988 and 2006, 69715 patients were diagnosed with stages pT1-4pN0-2M0 RCC within 17 Surveillance, Epidemiology and End Results (SEER) registries. A composite SES variable was created by combining education, poverty and family income data. Logistic regression models tested the impact of SES on the rate of locally-advanced RCC after adjusting for age, gender, race, marital status, year of diagnosis, tumor size, grade and histological subtype. RESULTS The overall rate of locally-advanced RCC was 23.9% (n=16679). Of all patients, 16927, 18035, 17371 and 17382 were classified as lowest, low, intermediate and high SES. In univariable analyses addressing the presence of pT3-4 or pN1-2 stage at diagnosis, SES was a statistically significant predictor. Specifically, patients in the lowest SES quartile were 1.10-fold more likely to have locally-advanced stage at diagnosis (p<0.001). In multivariable analysis, SES achieved the independent predictor status (p<0.001) and patients in the lowest SES quartile showed a 1.12-fold higher risk of harboring locally-advanced disease relative to high SES patients. Advanced patient age (p<0.001), male gender (p<0.001), larger tumor size (p<0.001) and higher tumor grade (p<0.001) also achieved the independent predictor status. CONCLUSIONS Low SES is an independent predictor of locally-advanced RCC. This implies that low SES may represent a barrier to timely diagnosis of non-metastatic RCC. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e697-e698 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Giovanni Lughezzani Milano, Italy More articles by this author Lars Budaus Hamburg, Germany More articles by this author Rodolphe Thuret Montpellier, France More articles by this author Claudio Jeldres Montreal, Canada More articles by this author Daniel Liberman Montreal, Canada More articles by this author Shahrokh F. Shariat Montreal, Canada More articles by this author Hugues Widmer Montreal, Canada More articles by this author Philippe Arjane Montreal, Canada More articles by this author Wassim Kassouf Montreal, Canada More articles by this author Markus Graefen Hamburg, Germany More articles by this author Francesco Montorsi Milano, Italy More articles by this author Paul Perrotte Montreal, Canada More articles by this author Pierre I. Karakiewicz Montreal, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...