Kerr lens mode locking strongly depends upon intensity. Low pulse intensity weakens the nonlinear Kerr lens, and eventually mode locking is not supported. We demonstrate efficient mode-locking in a Ti:Sapphire laser oscillator with record-low intra-cavity pulse intensity (18 GW/cm2) and intra-cavity average power (340 mW). Using an additional nonlinear window in the cavity, the Kerr nonlinearity can be enhanced by an order of magnitude compared to the standard Ti:Sapphire cavity, allowing mode locking with an output coupler reflectivity as low as R = 55% and record-low intra-cavity pulse intensity. Our results provide an important new possibility to control mode-locking in cavities with very low intra-cavity pulse intensity, such as semiconductor laser oscillators and high-repetition rate mode-locked lasers.