High-quality Tools Research Articles

SOCIAL NETWORKS AS A MODERN TOOL IN CAREER GUIDANCE COUNSELING WITH FUTURE APPLICANTS OF THE INFORMATION SECTOR

<p><strong><em>The purpose</em></strong><em> of the study is to highlight the role of social networks as one of the modern means of career guidance work in higher education institutions, which allows to effectively acquaint applicants with the prospects of majors, presenting them with all important and relevant information.</em></p><p><strong><em>Research methodology. </em></strong><em>During the research, the following methods were used: descriptive (to specify the theoretical foundations of the work); analysis and synthesis, structural (for generalization and systematization of the obtained data).</em><em></em></p><p><strong><em>Results</em></strong><em>. It is emphasized that social networks in career guidance work are a popular element of the modern information space, a high-quality tool for establishing a connection between universities and future applicants, as well as a platform for joint activities for the purpose of consulting, searching and informing. It has been established that the use of social networks will allow to significantly expand the reach of the target audience, apply online marketing strategies to promote the offer, and adapt the form and content of career guidance materials to its characteristics. The Facebook and Instagram community «MediaBiznes#MBKNUCaA» of the specialty «Information, library and archival business», which was created at the department of «Event management and social communications» of the separate division «Mykolaiv branch of the Kyiv National University of Culture and Arts» for the rapid dissemination of information among teachers of the department, students, exchange of files, video and audio materials of an educational and scientific nature and involvement of future entrants in the field of information activities. The possibilities of social networks represent, in our opinion, the basis of an effective strategy for the development of modern educational systems in general, will enrich and expand information about the future specialty, will significantly deepen the horizons of future applicants who will purposefully choose information activities.</em></p><p><strong><em>Novelty</em></strong><em>. The novelty of the obtained results is due to the fact that, despite the active interest of the scientific community in the use of social networks as a modern tool in career guidance work with future entrants of the information field, there are no serious generalization works.</em></p><p><strong><em>Practical meaning. </em></strong><em>The results of the research can be used during the implementation of tools in career guidance activities in institutions of higher education.</em><em></em></p><p><strong><em>Key words: </em></strong><em>social networks, career guidance, higher education, entrants in the field of information activities, professional choice, advertising support.</em></p>

The re-discovery in Sumatra of a rarely seen moth, Heterosphecia tawonoides, and its identification using citizen science platform iNaturalist.

Traditional methods of species identification involve collection and killing of specimens. The associated costs and expertise required are prohibitory. In this paper we describe the first documented record of Heterosphecia tawonoides in its natural habitat in Sumatra since 1887, reporting its identification using photographs uploaded to citizen science platform iNaturalist. Our findings add valuable information to the small body of work on this species and demonstrate the importance of having freely available high quality tools such as iNaturalist without which this important record would not have been reported and the observation of this rarely seen moth species in Sumatra would have remained unknown.

Distance learning as a relevant educational technology in higher education institutions

The relevance of the subject is conditioned upon the fact that the current conditions, namely the COVID-19 epidemic and the introduction of martial law in Ukraine, cause dynamic changes in various spheres of human activity, including education. Despite internal and external obstacles, the educational process does not stop, and there is a need to adapt to large-scale changes in the country. The educational sector has transformed from the conventional form of the educational process, namely face-to-face, to online distance learning. Considering this, the purpose of the study is to analyse the peculiarities of implementing the distance learning process in a higher education institution in Ukraine, namely, the Higher Educational Institution of the Ukoopspilka “Poltava University of Economics and Trade”. For a broad understanding of the problem and outlining the prospects for a quality educational process in the context of global processes, the study used several methods, including analysis, synthesis, deduction and surveys. The study outlines the main changes implemented by the management of higher education institutions in response to the social challenges posed by the pandemic and war. The effectiveness of using special programmes during training sessions in the distance education process is assessed. The flexibility of the educational sphere is substantiated, and the advantages and disadvantages of distance learning in terms of the quality of education are identified. The results of a student survey reflecting the real attitude of students to online learning are presented. The practical value of the work is that its results can be used by teachers to select high-quality tools designed to implement learning tasks in a distance educational format.

ROLE AND CONTRIBUTION OF PRINTMAKING TO THE MODERN INDIAN ART

The purpose of this research paper is to provide a chance to travel through the process of looking for and discovering new events that occurred throughout the development of printing in India. The constant drive to build and establish printing workshops is where the innovation, handiwork, and creativity that are driving the industry's expansion can be found. Printmaking is an art form that emerges as a result of the combination of technical expertise and creative visualization. One must not only have access to high-quality tools but also be familiar with how to properly use them. Therefore, it is of the utmost importance to have a solid understanding of the various printing processes. The fact that printing was accessible to the general public was the defining characteristic of this century. Because of its accessibility, low cost, ease of communication, and mobility, it quickly rose to prominence among the general population. After a few decades, the same thing that happened in Europe occurred in India as well. In the beginning, the weight that was placed on its practical advantages was mostly because it was thought of as being more technique- or craft-oriented than other modes of expression. In the process of producing works of popular art, the role of the printer was analogous to that of a technician. His approach to language and way of communication never really materialized into something noteworthy. The identities of several of these skilled printmakers were never revealed. In the Western world, many artists turned to print as a means of promoting their work or just experimenting with new mediums. It's interesting to note that the situation was the same in our nation. The sole purpose for which Ravi Varma installed his printing press was to make copies. A great number of Indian artists only utilized printing to experiment, and they were content with producing only a few pieces in this medium. The process of printmaking went through a lengthy development phase until it finally reached the stage of maturity that enabled it to take its rightful place in the center of the printing scene on a global scale

A precision medicine tool for high utilization and quality of individual treatment trials with immunomodulatory drugs in mucopolysaccharidosis

A precision medicine tool for high utilization and quality of individual treatment trials with immunomodulatory drugs in mucopolysaccharidosis

Development of Complementary Encounter and Patient Decision Aids for Shared Decision Making about Stroke Prevention in Atrial Fibrillation.

Decision aids (DAs) are helpful instruments used to support shared decision making (SDM). Patients with atrial fibrillation (AF) face complex decisions regarding stroke prevention strategies. While a few DAs have been made for AF stroke prevention, an encounter DA (EDA) and patient DA (PDA) have not been created to be used in conjunction with each other before. Using iterative user-centered design, we developed 2 DAs for anticoagulation choice and stroke prevention in AF. Prototypes were created, and we elicited feedback from patients and experts via observations of encounters, usability testing, and semistructured interviews. User testing was done with 33 experts (in AF and SDM) and 51 patients from 6 institutions. The EDA and PDA underwent 1 and 4 major iterations, respectively. Major differences between the DAs included AF pathophysiology and a preparation to meet with the clinician in the PDA as well as different language throughout. Content areas included personalized stroke risk, differences between anticoagulants, and risks of bleeding. Based on user feedback, developers 1) addressed feelings of isolation with AF, 2) improved navigation options, 3) modified content and flow for users new to AF and those experienced with AF, 4) updated stroke risk pictographs, and 5) added structure to the preparation for decision making in the PDA. These DAs focus only on anticoagulation for stroke prevention and are online, which may limit participation for those less comfortable with technology. Designing complementary DAs for use in tandem or separately is a new method to support SDM between patients and clinicians. Extensive user testing is essential to creating high-quality tools that best meet the needs of those using them. First-time complementary encounter and patient decision aids have been designed to work together or separately.User feedback led to greater structure and different experiences for patients naïve or experienced with anticoagulants in patient decision aids.Online tools allow for easier dissemination, use in telehealth visits, and updating as new evidence comes out.

Isolation and Identification of Fungi Associated with Avocado Pear (Persea americana Mill)

This study's objective is to separate and identify harmful fungus from spoiled avocado pears. Healthy avocado pear fruits were delivered to the lab and left to rot on a lab bench after being purchased from Awka, Nnewi, and Ihiala. Potato dextrose agar (PDA) and SDA agar were used to test the fruits for the presence of fungal infections that cause deterioration. According to the findings, PDA media exhibit greater growth than SDA, and ther45 x 102 CFU/g).e was no statistically significp > 0.005ference (p>0.005) between the fungal counts of the avocado and pear samples collected from the three different sites, with the Eke Awka market sample showing the highes48 x 102 CFUcount (48x102cfu/g), followed by the Total Market47 x 102 CFUample (47x102cfu/g), and the Nnewi market sample showing the lowest fungal count (45x102cf Based on their colonial and physical traits, the fungus responsible for the fruit deterioration was identified. The investigation also revealed that a total of 5 isolates of fungus from fruits, including Aspergillus spp., Penicillium spp., Rhizopus sp., Fusarium spp., and Candida spp., were collected. Of them, isolates of Aspergillus niger species were found most commonly (36%). Rhizopus species and Candida were next, each with an infection incidence of 18%, while Fusarium solani and Penicillium digitatum were the least common (141%). Aspergillus niger, one of the identified fungi, was the least harmful and produced the least amount of fruit rot. R. stolonifer, Fusarium solani, Candida tropicalis, and Penicillium digitatum were the least pathogenic and caused the most fast disintegration of treated fruits in 3-5 days. This study has demonstrated that fungus is to blame for fruit rotting. This study has demonstrated that fungus is to blame for fruit rotting. Producing, preparing, and preserving foods like fruit salads must be done as quickly and hygienically as possible using high-quality tools, products, and materials since fruits are typically infested by harmful fungus.

Branched Neural Network based model for cutter wear prediction in machine tools

Cutter wear has a great impact on machining quality, which is particularly true when demand for machining accuracy is high. Therefore, cutter wear analysis is critical in assuring high machining quality and long tool life. However, it is highly dangerous and difficult to monitor and determine tool wear conditions during machining. This paper proposes a method of real-time machining status monitoring using the data collected by external sensors without interfering with the machining process. A tool wear forecast model is introduced in this article. Multiple process parameters and sensor data are collected. Due to missing data, however, data preprocessing is done applying the interpolation or extrapolation approach and data are standardized in order to create an artificial intelligence-based model. The said model will then be used to forecast tool wear during different processing stages and be compared with other different models, such as: AdaBoost, Support Vector Machine, Decision Tree, and Random Forest. The model developed in this study is based on a Branched Neural Network, which generates the best prediction results among all publicly available algorithms. This approach helps reduce the mean absolute error and root-mean-square error values and can improve by 0.11 in R2.

Engineering an SspB-mediated degron for novel controllable protein degradation

Elegant controllable protein degradation tools have great applications in metabolic engineering and synthetic biology designs. SspB-mediated ClpXP proteolysis system is well characterized, and SspB acts as an adaptor tethering ssrA-tagged substrates to the ClpXP protease. This degron was applied in metabolism optimization, but the efficiency was barely satisfactory. Limited high-quality tools are available for controllable protein degradation. By coupling structure-guided modeling and directed evolution, we establish state-of-the-art high-throughput screening strategies for engineering both degradation efficiency and SspB-ssrA binding specificity of this degron. The reliability of our approach is confirmed by functional validation of both SspB and ssrA mutants using fluorescence assays and metabolic engineering of itaconic acid or ferulic acid biosynthesis. Isothermal titration calorimetry analysis and molecular modeling revealed that an appropriate instead of excessively strong interaction between SspB and ssrA benefited degradation efficiency. Mutated SspB-ssrA pairs with 7–22-fold higher binding KD than the wild-type pair led to higher degradation efficiency, revealing the advantage of directed evolution over rational design in degradation efficiency optimization. Furthermore, an artificial SspB-ssrA pair exhibiting low crosstalk of interactions with the wild-type SspB-ssrA pair was also developed. Efforts in this study have demonstrated the plasticity of SspB-ssrA binding pocket for designing high-quality controllable protein degradation tools. The obtained mutated degrons enriched the tool box of metabolic engineering designs.

System modernization of the Union state industrial base

The necessity of having high-quality tools for the balanced development of the diversified complex of the Union State is substantiated. Based on existing developments, a working model of economic planning has been formed, supplemented with modern mathematical tools that have proven themselves in the recent past and can be used today with great efficiency.

Application and Inspiration of Information System used in National Health and Nutrition Examination Survey of America

The National Health and Nutrition Examination Survey (NHANES) of America has been running for more than 60 years and has achieved many significant achievements with international influence. The application of modern information technologies in NHANES provides a supplementary tool for the project's high quality and refined implementation. This paper introduces the information system of NHANES from seven aspects: project management, survey participant interview, physical examination, laboratory examination, field follow-up, data sharing, and social services. The construction and application prospects of the China National Health Survey Information System, suitable for China's native conditions, are also discussed in this article.

Marine spatial planning in Croatia

The introduction of marine spatial planning (hereafter: MSP) for Croatia is essential, considering the coastline length and the increasing usurpation of coastal and marine space. MSP is more than a process that regulates the activities on the sea. It is an analytical approach to the setup of human activities in the marine area. As a maritime country, Croatia has ratified the Protocol on Integrated Coastal Zone Management and undertook the obligations of the Barcelona Convention. However, an appropriate document has not yet been made that would enable quality management of marine space. MSP and its onshore version contribute to the establishment and development of various activities, taking into account environmental, natural, economic, and sociological criteria. MSP is a continuation of spatial planning of the mainland area and must undoubtedly consider the more expansive coastal environment and the activities there. One of the tools in marine area mapping is the Geographic Information System (GIS), which has proven to be a very high quality and effective tool, especially in decision-making processes. The authors analyze the existing legal framework for marine spatial planning. Particular emphasis is placed on the obligations facing the Republic of Croatia to implement marine spatial planning. Given that the paper seeks to determine the advantages of MSP implementation using modern tools in marine area mapping, the authors in the third part discuss the benefits of using GIS as an acceptable tool in mapping marine space and provide recommendations for further actions.

Abstract 1874: Use of high throughput SPR to characterize antibodies to common cancer biomarkers

Abstract As a disease of mis-regulation, cancer is characterized both genetically and proteomically, requiring high quality tools to dissect the change difference between cell states. Among the reagents used to characterize biological systems at the protein level, antibodies are routinely applied, and engineered versions have proven useful for treating multiple therapeutic indications. We have generated a human proteome wide toolbox of polyclonal antibodies, identifying three antigenic 14mer sequences within each of the 20,000+ open reading frames at N-terminal, middle and C-terminal regions. Using a high throughput SPR system, Carterra LSA, we are able to define average on-rates, off-rates, and KD’s for pAb’s generated to important cancer regulators and biomarkers, including KRAS, STAT3, and Gli1. Due to the small size of the peptide targets, the kinetics of the observed interactions with polyclonal antibodies exhibit remarkable 1:1 fit typically observed when measuring monoclonal antibody affinities. The platform is a sensitive system capable of both identifying multiple antibody-antigen interactions with KD in the nanomolar to picomolar range, but also as a mass screening tool for developing de novo antibody pairs. We define the kinetic characteristics of these antibody reagents relative to performance in western blotting specifically. Improving the characterization of such widely used tools is critical for advancing translational opportunities into use in the clinic. Citation Format: Sergei Bibikov, John Rosenfeld, Kevin J. Harvey. Use of high throughput SPR to characterize antibodies to common cancer biomarkers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1874.

Monitoring the Surface Elevation Changes of a Monsoon Temperate Glacier with Repeated UAV Surveys, Mainri Mountains, China

Due to the deep valleys, steep mountains and the influence of the Indian monsoon on the Mainri Mountains (Yunnan Province, China), it is difficult to estimate glacier change from microwave and optical remote sensing. To bridge the gap between low-quality space-borne remote sensing and scarce in situ measurements, airborne remote sensing, such as unmanned aerial vehicles (UAVs), may provide a remarkable opportunity to monitor glacier change with high-quality tools. To determine monsoon temperate glacier change, three UAV surveys were conducted on the Melang Glacier in the Mainri Mountains in November 2019, April 2020 and November 2020. Then, glacier surface elevation changes were estimated from UAV orthophotos and DSMs. High accumulation and high ablation (+10.5 m and −13.5 m) were observed in the accumulation period and ablation period, with a mean surface elevation change of −3.0 m in the surveyed glacier area from November 2019 to November 2020. The avalanche, debris cover, ice cliffs and proglacial lake resulted in a heterogeneous pattern of glacier surface elevation changes. Given that the glacier is more sensitive to temperature, the Melang Glacier may have experienced a substantial recession and mass loss in the past few decades. This study provides a more appropriate approach for monitoring the changes in a temperate glacier in the Mainri Mountains.

Validation of a Smartphone-Based Institutional Electronic Data Capture System for Thumb Carpometacarpal Joint Arthroplasty.

The Orthopaedic Minimal Data Set (OrthoMiDaS) Episode of care (OME) is a prospectively collected database enabling capture of patient and surgeon-reported data in a more efficient, comprehensive, and dependable manner than electronic medical record (EMR) review. We aimed to assess and validate the OME as a data capture tool for carpometacarpal (CMC) arthroplasty compared to traditional EMR-based review. Specifically, we aimed to: (1) compare the completeness of the OME versus EMR data; and (2) evaluate the extent of agreement between the OME and EMR data-based datasets for carpometacarpal (CMC) arthroplasty. The first 100 thumb CMC arthroplasties after OME inception (Febuary, 2015) were included. Blinded EMR-based review of the same cases was performedfor 48 perioperative variables and compared to their OME-sourced counterparts. Outcomes included completion rates and agreement measures in OME versus EMR-based control datasets. The OME demonstrated superior completion rates compared to EMR-based retrospective review. There was high agreement between both datasets where 75.6% (34/45) had an agreement proportion of >0.90% and 82.2% (37/45) had an agreement proportion of >0.80. Over 40% of the variables had almost perfect to substantial agreement (κ > 0.60). Among the 6 variables demonstrating poor agreement, the surgeon-inputted OME values were more accurate than the EMR-based review control. This study validates the use of the OME for CMC arthroplasty by illustrating that it is reliably able to match or supersede traditional chart review for data collection; thereby offering a high-quality tool for future CMC arthroplasty studies.

Inequities in Health Care Services Caused by the Adoption of Digital Health Technologies: Scoping Review.

BackgroundDigital health technologies (ie, the integration of digital technology and health information) aim to increase the efficiency of health care delivery; they are rapidly adapting to health care contexts to provide improved medical services for citizens. However, contrary to expectations, their rapid adoption appears to have led to health inequities, with differences in health conditions or inequality in the distribution of health care resources among different populations.ObjectiveThis scoping review aims to identify and describe the inequities of health care services brought about by the adoption of digital health technologies. The factors influencing such inequities, as well as the corresponding countermeasures to ensure health equity among different groups of citizens, were also studied.MethodsPrimary studies and literature, including articles and reviews, published in English between 1990 and 2020 were retrieved using appropriate search strategies across the following three electronic databases: Clarivate Analytics’ Web of Science, PubMed, and Scopus. Data management was performed by two authors (RY and WZ) using Thomson Endnote (Clarivate Analytics, Inc), by systematically screening and identifying eligible articles for this study. Any conflicts of opinion were resolved through discussions with the corresponding author. A qualitative descriptive synthesis was performed to determine the outcomes of this scoping review.ResultsA total of 2325 studies were collected during the search process, of which 41 (1.76%) papers were identified for further analysis. The quantity of literature increased until 2016, with a peak in 2020. The United States, the United Kingdom, and Norway ranked among the top 3 countries for publication output. Health inequities caused by the adoption of digital health technologies in health care services can be reflected in the following two dimensions: the inability of citizens to obtain and adopt technology and the different disease outcomes found among citizens under technical intervention measures. The factors that influenced inequities included age, race, region, economy, and education level, together with health conditions and eHealth literacy. Finally, action can be taken to alleviate inequities in the future by government agencies and medical institutions (eg, establishing national health insurance), digital health technology providers (eg, designing high-quality tools), and health care service recipients (eg, developing skills to access digital technologies).ConclusionsThe application of digital health technologies in health care services has caused inequities to some extent. However, existing research has certain limitations. The findings provide a comprehensive starting point for future research, allowing for further investigation into how digital health technologies may influence the unequal distribution of health care services. The interaction between individual subjective factors as well as social support and influencing factors should be included in future studies. Specifically, access to and availability of digital health technologies for socially disadvantaged groups should be of paramount importance.

Submicron Ti(C,N)-based cermets with improved microstructure using high-energy milled and subsequent heat-treated ultrafine Ti(C,N) powders

Ti(C,N)-based cermets with ultrafine or submicron black core-rim grains are attracting candidates for high-quality tools and dies, due to their high hardness and strength. However, high chemical activity of ultrafine Ti(C,N) powders lead to the increased instability and difficulty to control the sintering process, since the denitrification and interface diffusion are accelerated during the solid-state reaction. Based on this, owing to the unrealized commercial ultrafine-grade powders, ultrafine Ti(C,N) powders with an average grain size around 150 nm, low oxygen content and few dislocations are fabricated via the high-energy ball milling and subsequent heat treatment of commercial micron Ti(C,N) powders. Related morphology evolution, microstructure and composition of the ultrafine Ti(C,N) powders are investigated. Dense submicron Ti(C,N)-based cermets with grain size of 0.62 μm and uniform core-rim phases are successfully prepared by using the as-fabricated ultrafine Ti(C,N) powders. Compared to cermets via the conventional high-energy milling route, submicron Ti(C,N)-based cermets exhibit higher hardness of 1750 ± 40 N/mm2, bending strength of 1960 ± 135 MPa, and satisfactory fracture toughness of 9.2 MPa m1/2, owing to smaller grain size, uniform microstructure and partial black core-rim grains.

First evidence of crucible steel production in Medieval Anatolia, Kubadabad: A trace for possible technology exchange between Anatolia and Southern Asia

In this article, we present the first archaeological evidence for crucible steel production in Anatolia uncovered in recent excavations at Kubadabad, which was built as a palace by the Anatolian Seljuks in the early 13th century AD. Along with plenty of crucible sherds recovered at the site, blades made of crucible steel, production waste-iron chunks and manganese oxide pellets also revealed remarkable information about the process of production. Based on the results of the archaeometry analysis of crucibles of a unique shape with a pointed base, it was discovered that the fabric of the crucible was tempered with finely crushed charcoal, straw and quartz-containing sand. In addition, metallography and SEM analysis conducted on the metal finds demonstrated that high-quality tools were produced from manganese alloy crucible steel ingots at the site. This study evaluates most of the finds found at Kubadabad from the end of the 13th century AD, when some of the buildings were converted into workshops for decorated ceramic tiles and metal production under Ilkhanid patronage or Turkish beyliks. Using analytical results and archaeological findings, we discuss the historical connections of crucible steel production in Kubadabad, which differs from the Central Asian and Persian traditions, but shares similarities with the Southern Asian tradition.

Beyond Beauty. Byzantine steatite icon from Chełm. Archaeology, Petrography and Traceology

Abstract A fragmentarily preserved Byzantine icon made of steatite was discovered in 2015 during regular excavations in Chełm, eastern Poland. Identified as the left wing of a diptych illustrating the Twelve Great Feasts and created at the close of the 12th century, the find is one of the most important and beautiful Byzantine artefacts to have been found in Poland. The icon was uncovered within the confines of the palace complex which was created by Daniel (Danylo) Romanovych († 1264) in Chełm in the second quarter of 13th century. The icon, even though it was found within the borders of what is now Poland, is material evidence of contact between Byzantium and the social elite of the Galicia-Volhynia lands, rather than with the Polish Piasts. In this paper we concentrated on the presentation of the archaeological context of the find, which made it possible to establish that the icon arrived Chełm before the middle of the 13th century (terminus ante quem 1253), and especially on petrographic and traceological analyses of the icon. Assuming that greenish plaques were indeed the most characteristic steatite icon type, a decision was made to examine, apart from the Chełm artefact made from white rock, a greenish icon from the National Museum in Krakow as well. Petrographic analyses were based on optical microscopy, scanning electron microscopy with energy dispersive spectrometry (SEM-EDS) and X-ray powder diffraction (XRPD). Both icons were carved in steatite i. e. talc rich rock but their chemical compositions indicate the presence of other components. Artifact from Chełm is white. Porous, enriched in potassium (K) and locally blistering outer rim of the icon from Chełm was formed probably during the fire event. Presence of forsterite and subordinate amount of leucite also indicate high temperature influence. Local enrichment in calcium (Ca) is related to exchange reactions with ground compounds. Accumulation of different components on the surface of the icon’s surface was noted. The icon from the National Museum in Krakow is greenish probably because of the presence of chlorite. The results of the traceological analysis (icon from National Museum in Krakow was not analysed) indicate that the icon found in Chełm was created most likely by a skilled and experienced carver with access to the high-quality magnifying glass and specialist tools required for rendering minuscule objects and their details. The production of the icon also involved the use of a “mechanical” tool, probably a kind of a miller with a rotating polishing head, which also seems to point to a specialist workshop. The use-wear traces observed on artefact are limited to polish resulting from prolonged contact with human hands or storing the icon in a leather case. Most of the extant Byzantine icons are unprovenanced objects held in museum collections or church treasuries. Therefore, as the icon presented in this paper was discovered during archaeological excavations, it ranks among the few Byzantine artefacts to have been found outside of this realm. The petrographic and traceological analyses conducted are the first published natural science contributions to the study of Byzantine steatite icons and we hope they will provide the impetus for undertaking such research on other Byzantine finds, helping to develop Byzantine archaeology further.

LB756 Patient-reported outcomes for sarecycline effectiveness in Acne Vulgaris in real-world settings: PROSES study protocol

Introduction: The detrimental psychosocial impact of acne vulgaris is well established. Patient-reported outcomes are needed to fully understand the psychosocial benefits of acne treatment. Sarecycline, a novel narrow-spectrum antibiotic, demonstrated efficacy, safety, and improvement in health-related quality of life (HRQOL) in clinical trials and is approved for treatment of moderate-to-severe acne. In 2020, a consensus panel generated a 10-question expert panel questionnaire (EPQ), which, along with the validated acne symptom and impact scale (ASIS), was considered a high-quality tool for real-world assessment of patient-reported HRQOL.