The deployment of constellations of satellites within low Earth orbit (LEO) has implications for space operations and for the broader space environment. A large active satellite population will experience high numbers of conjunctions with other resident space objects (RSOs). Even if only a small proportion are high-probability events, the substantial number of conjunctions will still lead to many potentially high-risk encounters with other RSOs and a correspondingly high burden for their operators to mitigate them via maneuvers. This burden is exacerbated if the operator adopts an approach whereby risk mitigation maneuvers are conducted at collision probability levels below the widely accepted 1E-4 (1-in-10,000). Despite these significant efforts the remaining aggregate risk may still be relatively high because of the large number of conjunctions experienced by some constellations, leading to ongoing concern over the safety of these space systems. Through an analysis of conjunction assessment data, simulations using the DAMAGE computational model, and a new mapping approach, the risks from conjunctions between large constellations and other RSOs have been investigated. The results show that some existing constellations currently face more than a 10 % annual collision probability even after accounting for their robust risk mitigation approaches, with implications for the safety and long-term sustainability of large constellations and the broader LEO environment. Overall, the work emphasizes the need for new research and guidance on this aspect of space operations.