High Prevalence Of Injuries Research Articles

Analysis of exosome-derived microRNAs as early biomarkers of lipopolysaccharide-induced acute kidney injury in rats.

Sepsis contributes to the high prevalence of acute kidney injury (AKI), which mainly occurs in hospitalized patients. The delay in AKI detection is a risk factor for death and chronicity; thus, early diagnosis is essential for initiating proper treatment strategies. Although serum creatinine is used as biomarker, it is increased in plasma serum creatinine only at late stages of AKI. MicroRNAs (miRNAs), a class of noncoding RNAs responsible for gene regulation, can be found in biological fluids within vesicles such as exosomes and may be promising tools for the early detection of AKI. We aimed to identify potential blood miRNAs that can be used as early biomarkers of sepsis-induced AKI in rats. Adult male Wistar rats received a single dose of lipopolysaccharide (LPS). The earliest significant increase in serum creatinine was detected 4 h after LPS administration. To evaluate whether miRNAs could act as early biomarkers, blood samples were collected before and 2 h after LPS infusion. Serum NGAL levels were used as a comparative marker. Serum miRNAs were derived from exosomes, and their expression were evaluated by the PCR array. miR-181a-5p and miR-23b-3p showed higher expression in LPS-treated rats than in the control animals (p < 0.05). Bioinformatics analysis showed that both miRNAs target molecules associated with transcription factors that regulate genes related to proinflammatory cytokines. Considering that LPS activates transcription factors that lead to the production of proinflammatory cytokines, possible premature changes in the serum levels of miR-181a-5p and miR-23b-3p may be used to identify sepsis-induced AKI earlier.

A Real Pandora's Box in Pandemic Times: A Narrative Review on the Acute Cardiac Injury Due to COVID-19.

The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there is an ever-increasing amount of evidence that reports a high prevalence of acute cardiac injury in the context of viral infection. In patients with Coronavirus disease 2019, COVID-19, a significant increase in serum levels of cardiac troponin or other various biomarkers was observed, suggesting acute cardiac injury, thus predicting both a severe course of the disease and a poor outcome. Pathogenesis of acute cardiac injury is not yet completely elucidated, though several mechanisms are allegedly involved, such as a direct cardiomyocyte injury, oxygen supply-demand inequity caused by hypoxia, several active myocardial depressant factors during sepsis, and endothelial dysfunction due to the hyperinflammatory status. Moreover, the increased levels of plasma cytokines and catecholamines and a significantly enhanced prothrombotic environment may lead to the destabilization and rupture of atheroma plaques, subsequently triggering an acute coronary syndrome. In the present review, we focus on describing the epidemiology, pathogenesis, and role of biomarkers in the diagnosis and prognosis of patients with acute cardiac injury in the setting of the COVID-19 pandemic. We also explore some novel therapeutic strategies involving immunomodulatory therapy, as well as their role in preventing a severe form of the disease, with both the short-term outcome and the long-term cardiovascular sequelae being equally important in patients with SARS-CoV-2 induced acute cardiac injury.

Work-related injuries among 5 – 17 years-old working children in Egypt: findings from a national child labor survey

BackgroundEgypt has agreed and ratified international regulations that strict child labor. However, the country still struggles with high prevalence of child labor and the associated negative social and health effects. The objective of this study was to identify the prevalence and determinants of work-related injuries among working children in Egypt.MethodsThis study involved a secondary data analysis of the National Child Labor Survey (NCLS) conducted in 2010 by The Central Agency for Public Mobilization and Statistics (CAPMAS) in Egypt with technical and financial support from the ILO’s International Program on the Elimination of Child Labor (IPEC) through its Statistical Information and Monitoring Program on Child Labor (SIMPOC). The total number of working children who responded to questions of work-related injuries in the NCLS child questionnaire was 7485 children.ResultsThe prevalence of work-related injuries among working children in Egypt was estimated as 24.1% (95% CI: 22.0%—26.2%), of whom the majority were superficial wounds (87.3%). Among children who reported work-related injuries, 57.9% did not stop work or schooling because of the most serious injury, while 39.6% had stopped temporarily and 2.6% had stopped completely. The main determinants of work-related injuries among working children in the study sample were gender (boys), age of starting work (5–11 years), type of main economic activity (industry and services), type of main workplace (plantation, farms, or garden), the average work hours per week (28 h or more), and exposure to ergonomic and safety, and chemical hazards at work.ConclusionsThe estimated high prevalence of work-related injuries among working children aged 5–17 years in Egypt raises the health risks concerns associated with child labor. Findings of this study on the determinants of work-related injuries could guide policies and interventions to combat child labor and the associated health risks, including work-related injuries.

Seizure-related injuries in people with epilepsy: A cohort study from Saudi Arabia.

ObjectivesPatients with epilepsy have a high risk of accidents and injuries, resulting in minimized physical activity and social withdrawal. Therefore, we surveyed the prevalence and the types of injuries that patients with epilepsy may endure, and the factors that may increase the risk of injuries.MethodsIn this cohort study, adult and pediatric patients diagnosed with epilepsy (age ≥ 7 years) and a close family member (parents/guardian) attending the outpatient epilepsy clinics at King Fahd Medical City (Riyadh, Saudi Arabia) were interviewed by neurologists. They reviewed the patients' medical records and administered a structured questionnaire to identify and compare several variables, including injury frequency versus seizure type and seizure frequency, number of antiseizure medications used, medication compliance, and work and social limitations.ResultsOut of 200 patients, 86 (43%) sustained injuries during an attack of their habitual seizures. Almost half of this group showed a tendency for recurrent injuries. The most common traumas were soft tissue injury (36.5%), head injury (32%), dental injury (8.5%), burns (7%), dislocation (7%), fractures (6.5%), and submersion (2%). Two‐thirds of the patients had their injury at home. 64% of patients who had seizures for more than 10 years sustained multiple injuries (P = .003). Injury frequency was higher among patients with daily or monthly seizures (P = .03). 76% of patients who suffered injuries more than twice had generalised tonic‐clonic seizures, and genetic generalised epilepsy was encountered more in injured patients (P = .02). Also, patients on polytherapy were more likely than those on monotherapy to have an injury (P = .003).SignificanceTwo‐fifths of the patients reported seizure‐related injuries. The most common were soft‐tissue injuries and head traumas, while homes were the most frequent site. In addition, longer epilepsy duration, generalized tonic‐clonic seizures, and polytherapy were associated with a higher prevalence of injuries. Therefore, injury prevention strategies should be developed for PWE, especially for those at higher risk.

Lumbar bone stress injuries and risk factors in adolescent cricket fast bowlers

ABSTRACT Cricket fast bowling is associated with a high prevalence of lumbar bone stress injuries (LBSI), especially in adolescent bowlers. This has not been sufficiently explained by risk factors identified in adult players. This study aimed to examine the incidence of LBSI in adolescent fast bowlers over a prospective study and potential risk factors. Forty asymptomatic male fast bowlers (aged 14–17 years) received baseline and annual lumbar dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) scans, and musculoskeletal and bowling workload assessment; 22 were followed up after one year. LBSI prevalence at baseline and annual incidence were calculated. Potential risk factors were compared between the injured and uninjured groups using T-tests with Hedges’ g effect sizes. At baseline, 20.5% of participants had at least one LBSI. Subsequent LBSI incidence was 27.3 ± 18.6 injuries per 100 players per year (mean ± 95% CI). Injured bowlers were older on average at the beginning of the season preceding injury (16.8 versus 15.6 years, g = 1.396, P = 0.047). LBSI risk may coincide with increases in bowling workload and intensity as bowlers step up playing levels to more senior teams during late adolescence whilst the lumbar spine is immature and less robust.

Prevalence and risk factors for non-collision injuries among bus commuters in Dar es Salaam, Tanzania

BackgroundMigration of people from rural to urban areas has led to the increase in demand for transportation services in the cities. However, authorities have failed to cope with this problem in a consistently manner. This has led to the increase in non-collision injuries among commuters. This study aimed at investigating the prevalence and risk factors for non-collision injuries among commuters using public transport in Dar es Salaam, Tanzania.MethodsA cross sectional study was conducted in Dar es Salaam involving 290 commuters from 7 bus routes travelling to and from the city centre using public transport which are privately owned and commonly known as “daladala”. Stratified random sampling was used to sample buses based on the passenger carrying capacity (i.e. 15-24, 25-34 and 35-45 passengers). Systematic random sampling was used to get a total of three commuters from each bus for the interview.ResultsLifetime prevalence of non-collision injuries was 71%, while these rates were 70 and 39% in the last 12 and 6 months, respectively. Commuters aged between 18 and 28 years experienced non-collision injuries the most (56%) in the last 12 months. Most non-collision injuries occurred on weekdays in the evening from 5:00 pm to 10:00 pm. Strong association was observed between the occurrence of non-collision injuries and commuting time between 5:00 pm to 10:00 pm (adjusted OR = 9.24; 95% CI: 2.68-19.54); boarding and disembarking (adjusted OR = 9.21; 95% CI: 3.77-25.11) and scrambling during boarding (adjusted OR = 5.03; 95% CI: 2.51-21.32). The lower limbs (adjusted OR = 8.64; 95% CI: 2.72-21.76) and the upper limbs (adjusted OR = 13.55; 95% CI: 5.32-33.21) were the most affected body parts.ConclusionsThis study has demonstrated high prevalence of non-collision injuries among commuters using public transport in Dar es Salaam. Travelling in the evening between 5:00 pm to 10:00 pm on the weekdays, boarding and disembarking especially when scrambling for the bus during boarding, overcrowding in the bus especially when the bus is already full with no seats available are the major risk factors for non-collision injuries.

Pelvic bone defects and possibilities of their replacement

In the work the review of actual literature sources concerning modern methods of treatment of osteochondral injuries was carried out, the features of anatomical and physiological structure of the talus, features of its blood supply were considered, etiological factors of formation of osteochondral injuries of the talus were presented, the high prevalence of ankle joint ligament apparatus injuries all over the world was noted. On the basis of the articles studied, topical problems of diagnostics and treatment of aseptic necrosis of the talus block and dissecting osteochondritis of the ankle joint were noted. The method of mosaic autochondroplasty of bone-cartilage graft is described, its differences from alternative methods with the use of allograft or juvenile cartilage graft are noted, and the features of all described methods are noted. Ceramic material based on lanthanum zirconate showing high osteointegrative properties is presented, which has been suggested for promising research in the field of osteochondral replacements.

Prognostic value of cardiac troponin in critically ill COVID-19 patients

Funding AcknowledgementsType of funding sources: None.Background/IntroductionAmong patients with COVID-19, there is a high prevalence of cardiovascular disease and myocardial injury from the infection, especially in critically ill patients.PurposeThis study sought to investigate the relationship between elevated admission high-sensitive troponin I in COVID-19 patients admitted to an intensive care unit (ICU) and prognosis.MethodsWe retrospectively analyzed patients consecutively admitted to an ICU with COVID-19, with a median follow-up of 10 months. Patients who were diagnosed with acute coronary syndrome, either died or were discharged within 48 hours of admission, and who did not have a cardiac troponin measurement in the first 48 hours, were excluded.Two groups were identified, with normal troponin and with elevated troponin. Groups were compared, with special interest regarding in-hospital mortality, duration of mechanical ventilation, in-hospital diagnosis of heart failure, and length of hospitalization. Global mortality (in-hospital and during follow up) and re-hospitalization were compared. To compare survival, a Kaplan-Meier curve with log rank test was performed.ResultsFrom a total of 219 patients, after applying the exclusion criteria, 100 patients were included in the analysis, mean age was 62.9 ±12.5 years, and 74% were male.Troponin was normal in 77% of patients and elevated in 23%. Median troponin was 11 (IQR=26) ng/L (reference range <34 ng/L).Patients with elevated troponin were older (66.5 ±12.0 vs 61.6 ±12.5 years, p=0.036). Gender, comorbidities, vasopressor use, and APACHE II score were similar among groups. Patients with elevated troponin presented a higher ICU mortality (16.9% vs 47.8%, p=0.002) and higher global mortality (22.1% vs 47.8%, p=0.016). Re-hospitalization rates, ICU length of stay and duration of mechanical ventilation were similar among groups.In multivariate analysis, after adjustment for age and APACHE II score, an elevated troponin remained an independent predictor of ICU mortality (OR=3.40, 95% CI 1.08-10.4, p=0.036), but not an independent predictor of global mortality (OR=2.75, 95% CI 0.86-8.80, p=0.087).Kaplan-Meier analysis (Figures 1 and 2) showed that patients with elevated troponin had higher ICU (p=0.008) and global mortality (p=0.008) when compared to patients with normal admission troponin.Conclusion(s)The present study shows that elevated high-sensitive cardiac troponin I at admission predicts ICU and global mortality in critically ill COVID-19 patients. Cardiac troponin is as easy-to-use tool that may help to identify patients who benefit from tighter monitoring both during hospitalization and after discharge.

Self-reported injuries among Canadian adolescents: rates and key correlates.

Injuries sustained by adolescents in Canada represent a costly public health issue. Much of the limited research in this area uses administrative data, which underestimate injury prevalence by ignoring injuries that are not treated by the health care system. Self-reported data provide population-based estimates and include contextual information that can be used to identify injury correlates and possible targets for public health interventions aimed at decreased injury burden. The 2017 wave of the Canadian Community Health Survey was used to calculate the prevalence of self-reported total, intentional and unintentional injuries. We compared injury prevalence according to age, sex, employment status, presence of a mood disorder, presence of an anxiety disorder, smoking and binge drinking. Analyses were performed using logistic regression to identify significantly different injury prevalence estimates across key correlates. Overall past-12-month injury prevalence among adolescents living in Canada was 31.4% (95% CI: 29.4%-33.5%). Most injuries were unintentional. All provinces had estimates within a few percentage points, except Saskatchewan, which had substantially higher prevalence for both overall and unintentional injury. Smoking and binge drinking were significantly associated with higher injury prevalence in most jurisdictions. Remaining correlates exhibited nonsignificant or inconsistent associations with injury prevalence. The data suggest that injury prevention interventions aimed at reducing alcohol consumption, particularly binge drinking, may be effective in reducing adolescent injury across Canada. Future research is needed to determine how provincial context (such as mental health support for adolescents or programs and policies aimed at reducing substance use) impacts injury rates.

Prevalence and psychosocial factors associated with serious injuries among in-school adolescents in eight sub-Saharan African countries

BackgroundInjury is one of the major causes of death and illness among children and adolescents worldwide. We sought to investigate the prevalence of serious injury and its associated factors among in-school adolescents in eight countries in sub-Saharan Africa.MethodsA sample of 14,967 in-school adolescents was drawn from the Global School-based Student Health Surveys conducted from 2012 to 2017 in eight sub-Saharan African countries. Data were collected using self-administered structured questionnaires. The prevalence of serious injuries was calculated using proportions while multivariable binary logistic regression analysis was carried out to determine the factors associated with serious injuries.ResultsApproximately 45% of in-school adolescents had experienced serious injuries during the past 12 months to the survey in the eight sub-Saharan African countries, with variations from 32.3% in Mauritius to 68.2% in Liberia. Adolescents who experienced bullying [aOR = 2.37, CI = 2.10, 2.68], those who engaged in physical fight [aOR = 2.14, CI = [1.87, 2.44], those who experienced an attack [aOR = 1.96, CI = [1.73, 2.22], those who felt anxious [aOR = 1.47, CI = 1.22,1.77], those who attempted suicide [aOR = 1.38, CI = 1.14, 1.65], truants [aOR = 1.33, CI = [1.17,1.51], current tobacco users [aOR = 1.42, CI = [1.01, 2.01] and current marijuana users [aOR = 1.78, CI = 1.08, 2.93] had higher odds of experiencing serious injuries. However, those whose parents or guardians respected their privacy had lower odds of experiencing serious injuries [aOR =0.78, CI = [0.68, 0.88] compared to those whose parents or guardians did not respect their privacy.ConclusionA relatively high prevalence of serious injuries among in-school adolescents was identified in the eight sub-Saharan African countries studied. Programs and interventions that target the reduction of injuries in educational institutions should take a keen interest in the factors identified in this study. To deal with injury victims, first aid services should be provided in school settings.

Prevalence of Training-related Knee Injuries among Jazan University Students with Determining Possible Related Risk Factors

Background: The articulating surface of the knee is the most commonly injured joint in athletes. However, there is a lack of proper prevalence and determinant estimations for knee injury among Jazan University students.&#x0D; Materials and Methods: This cross-sectional study aimed to determine the prevalence of knee injury among students at Jazan University, Saudi Arabia and to identify the associated risk factors. An online self-administered modified Arabic version of the Knee Injury and Osteoarthritis Outcome Score questionnaire was distributed to collect data from the students. 884 participants were included and met our inclusion criteria.&#x0D; Results: The overall prevalence of knee injuries was 18% (n = 156). Ninety-two injuries were due to sports activity. Men were 2.7 more likely to have a knee injury than women. Performing 2–3 hours of training every week increased the likelihood of knee injury by 1.7 times more than being inactive or performing only 1 hour of activity per week. An increase in the body mass index was associated with knee injury.&#x0D; Conclusion: Our study highlights the high prevalence of knee injury among male students with a high body mass index, especially those studying in medical colleges. Further large-scale research is needed to address the limitations of this study and generalize the results to a larger population.

Risk Factors Associated with Occupational Injuries Among Motor Vehicle Repair Workers: A Case Study of Kigandaini Juakali Sector Thika, Kenya

Aim: The study aimed to determine the associated factors for occupational injuries at Kigandaini Juakali sector, Thika town, Kenya&#x0D; Method: An occupational injury refers to a physical injury that a worker encounters while working, they include body cuts, burns, body punctures, and body abrasions. An analytical cross-sectional study design was applied. A stratified random sampling method was applied to recruit 260 respondents. Both qualitative and quantitative techniques of data collection were applied, whereby a semi-structured questionnaire, KII, and FGDs were used to collect data. To enhance data quality, Cronbach’s alpha was applied for quantitative data while word cloud was used for qualitative data. Chi-square and logistic regression were applied to determine the degree of association between occupational injuries and associated risk factors.&#x0D; Results: The annual prevalence rate of work-related injuries was (43.5%) and (39.8%) for the past two weeks. Body cuts at 78.8% were the most reported injuries. PPEs in suitable working condition (OR=39, 95%CI=12.73-119.66), whether PPEs were worn properly (OR=59, 95%CI=16.94-209.84), provision of occupational health and safety information (OR=2.5, 95%CI=1.23-5.28), Use of PPEs (OR=8.1, 95%CI=0.037-0.42), presence of safety information boards(OR=3, 95%CI=1.08-8.08) reduced the odds of work-related injuries while poor working condition (OR=2.5, 95%CI=0.19-0.85) increased the odds of having a work-related injury.&#x0D; Conclusion: The study reported a high prevalence of occupational injuries among motor vehicle repair workers. Poor working conditions increased the odds of having an occupational injury while the provision of occupational safety information, presence of safety boards, proper wearing of protective gears, use of full protective gears, use of protective gears in good working condition, and good perception on mandatory use PPEs reduced the odds of having an occupational injury. There is need to safeguard the necessary safety measure which will result to a safer working environment.

Altered Cervical Spine Position Results in Decreased Shoulder Rotation Strength.

Strength testing of shoulder rotation is commonly used in clinical examinations of the shoulder. People prone to shoulder injury, such as overhead athletes and manual trade workers, place their shoulders under tremendous amounts of stress when the cervical spine is in nonneutral positions. If these nonneutral cervical spine positions result in decreased shoulder strength, it may help explain the etiology of the high prevalence of shoulder injuries in these populations. Given standard clinical strength assessments are performed with a neutral cervical spine, an investigation into the effects of cervical spine rotation is warranted. We sought to compare isokinetic shoulder rotation strength while in a neutral position with rotated cervical spine positions, specifically (1) with the cervical spine rotated contralaterally with the shoulder elevated in the frontal plane and (2) with the cervical spine rotated ipsilaterally and the shoulder elevated in the scapular plane. A convenience sample of 52 individuals (height 170 ± 10 cm; weight 73 ± 18 kg, age 21 ± 2 years; 18 males, 34 females), without shoulder or cervical spine pathology participated in this study. Participants were screened for eligibility via questionnaire. Concentric shoulder internal and external rotation torque was measured through a 90° arc on an isokinetic dynamometer with the shoulder elevated 90° in the frontal plane, and again 45° anterior to the frontal plane (scapular plane). Two repetitions were performed in a single testing session with the participant's cervical spine in neutral in both planes, maximally rotated contralaterally in the frontal plane, and maximally rotated ipsilaterally with the shoulder in the scapular plane; the second repetition was used for analysis. The testing order was randomized. Data were imported into a platform for statistical parametric mapping analysis (a technique that allows data from the entire arc of motion to be compared with data from another arc to identify differences in the wave form) to compare strength between positions throughout 90° arc of motion. Rotating the cervical spine contralaterally with the shoulder in the frontal plane resulted in a decrease in external (2.24 Nm or 12% average difference; p < 0.001) and internal (2.22 Nm or a 6% average difference; p = 0.02) rotation strength with the forearm within 15° and 20° of the vertical position. Rotating the cervical spine ipsilaterally with the shoulder in the scapular plane resulted in a decrease in external rotation strength (1.27 Nm or a 6% average difference; p < 0.001) throughout nearly all the motion, with peaks approximately 20° and 60° from the horizontal position, and internal rotation strength (1.78 Nm or 5% average difference; p < 0.001) the last 60° towards the horizontal position. Patient populations who require strenuous use of their shoulders in altered cervical spine positions may be at increased risk for injury from decreased shoulder rotator strength. Clinicians should assess shoulder strength in the position the patient requires to use their shoulder because cervical spine position may cause weakness that would be missed in standard testing positions.

Surgeons Experience Greater Cardiorespiratory Strain and Stress During Total Hip Arthroplasty Than Total Knee Arthroplasty.

Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are physically demanding, with a high prevalence of work-related injuries among arthroplasty surgeons. It is unknown whether there are differences in cardiorespiratory output for surgeons while performing THA and TKA. The objective of this study is to characterize whether differences in surgeon physiological response exist while performing primary THA vs TKA. This is a prospective cohort study including 3 high-volume, fellowship-trained arthroplasty surgeons who wore a smart garment that recorded cardiorespiratory data on operative days during which they were performing primary conventional TKA and THA. Variables collected included patient body mass index (BMI), operative time (minutes), heart rate, heart rate variability, respiratory rate, minute ventilation, and energy expenditure (calories). Seventy-six consecutive cases (49 THAs and 27 TKAs) were studied. Patient BMI was similar between the 2 cohorts (P > .05), while operative time was significantly longer in TKAs (60.4±12.0 vs 53.6±11.8; P= .029). During THA, surgeons had a significantly higher heart rate (95.7±9.1 vs 90.2±8.9; P= .012), energy expenditure per minute (4.6±1.23 vs 3.8±1.2; P= .007), and minute ventilation (19.0±3.0 vs 15.5±3.3; P < .001) compared to TKA. Surgeons experience significantly higher physiological strain and stress while performing THA. While scheduling THAs and TKAs, surgeons should consider the higher physical demand associated with THAs and ensure adequate personal preparation and sequence of cases.

Is Injury an Occupational Hazard for Horseracing Staff?

Occupational health is a key priority for the horseracing industry, yet little research on occupational injuries exists. This study investigated the prevalence and the effect of injury in British horseracing staff during a 12-month period. An online retrospective survey was answered by 352 participants, identifying self-reported injury prevalence, injury management practices and attitudes towards workplace injury reporting. Chi Squared tests for independence were undertaken. A total of 310 (88.1%) staff reported injuries; risk factors for injury type included self-perceived job security, working hours, and perceived job control. Physical limitations, loss of confidence, workplace changes, and lifestyle implications were reported as consequences of injury. A total of 75.3% (n = 134) of staff were likely to seek time-off following fractures, but only 48.6% (n = 86) would take time-off for concussion. Attitudes towards injury management were influenced by financial circumstances, perceived staff shortages, previous injury experiences, and perceived employer expectations. The high self-reported injury prevalence could result in decreased workforce efficiency, poor physical health, and negative implications on retention and career longevity. The perception of invisible injuries, i.e., concussion, and subsequent management, should be of immediate concern to racing organizations. This paper identifies recommendations to enhance the safety and wellbeing of horseracing staff.

Prisoner knowledge about head injury is Improvedby brief psychoeducation

ABSTRACT Introduction The high prevalence of head injury (HI) in prisoners and its association with offending indicates a need for interventions. However, there is little evidence and none for the effectiveness of psychoeducation in improving prisoner knowledge about HI and its effects. Methods Small groups of males in two Scottish prisons underwent a 1 hour psychoeducation session delivered by PowerPoint and combined with question and answer, video clips and a booklet about HI. A pre-post intervention design was used to assess knowledge about HI from vignettes. Participants indicated effects of HI using unprompted free recall and then with a questionnaire (the Symptom Checklist; SCL), pre-education (n = 34), post-education (n = 19) and at 4-week follow-up (n = 11). Free recall was scored using symptom lists from national guidelines (FR-SIGN) or the SCL (FR-SCL). Within-subject comparisons were made between pre-intervention, post-intervention and follow-up scores. Results Knowledge about HI significantly increased pre- to post-education for FR-SIGN (d = 0.91; 95% CI 0.62, 2.53) and FR-SCL (d = 0.99; 95% CI 0.95, 4.00) without decrement at follow-up (FR-SIGN d = 1.27; 95% CI 0.53, 2.56; FR-SCL r = 0.60). Scores on the SCL did not change over time (p > .05). Conclusion Prisoner knowledge about HI was improved by brief psychoeducation suitable for delivery in prisons.

Abstract TP114: High Prevalence Of Acute Cerebrovascular Injury On Brain Magnetic Resonance Imaging In Acute Respiratory Distress Syndrome

Background: Acute Respiratory Distress Syndrome (ARDS) is an acute inflammatory respiratory failure condition that may be associated with secondary cerebrovascular injury. We aimed to describe the prevalence and types of cerebrovascular injuries detected by brain MRI among ARDS patients. Methods: We reviewed a single-center ARDS registry data from a tertiary medical center from January 2010 to October 2018. Patients who underwent brain MRI during their index hospitalization were identified. MRIs were reviewed by two independent reviewers. Acute cerebrovascular injuries were classified as acute cerebral ischemia (ischemic infarct and hypoxic ischemic brain injury [HIBI]) or intracranial hemorrhage (ICH) including intraparenchymal hemorrhage, subarachnoid hemorrhage, subdural hematoma, and cerebral microbleeds (CMBs). Descriptive statistics were conducted. Results: Of the 678 ARDS patients, 66 (9.7%) underwent brain MRI during their ARDS illness. The median time from hospital admission to MRI was 10 days (interquartile range 4-17). Of 66, 31 (47%) had MRI evidence of acute cerebrovascular injuries including acute cerebral ischemia in 33% (22/66) and ICH in 21% (14/66). Among those with cerebral ischemia, common findings were bilateral globus pallidus infarcts (n=7), multifocal ischemic infarcts (n=5), and HIBI (n=3). Twelve (86%) with CMBs constituted the most common type of ICH, followed by intraparenchymal hemorrhage (14%). Patient demographics, Charlson Comorbidity Index, or disease severity as measured by the presence of sepsis/sepsis shock, cardiac arrest, extracorporeal membrane oxygenation use, admission Acute Physiology and Chronic Health Evaluation III Score, Sequential Organ Failure Assessment Score, or admission PaO 2 /FiO 2 ratio did not differ among patients with and without cerebrovascular injury including cerebral ischemia or ICH. In-hospital mortality was significantly greater in ARDS patients with acute cerebral ischemia compared to those without ischemia (55% vs 27%, p=0.03). Conclusion: Among selected patients with ARDS who underwent brain MRI, a half had secondary cerebrovascular injury including acute cerebral ischemia and CMBs.

Perceived Discrimination and Injury at Work: A Cross-Sectional Study Among Latino Day Laborers.

Given the stigma of their undocumented status and their high prevalence of workplace injury, understanding the impact of discrimination on Latino day laborers (LDLs) is a criticalpublic health issue. We surveyed LDLs (N = 149) and assessed their sociodemographics, experiences of and perceived reasons for discrimination, and work-related injury. A logistic regression examined the association between discrimination and injury, adjusting for sociodemographics. Next, Chi-square tests identified perceived reasons for discrimination associated with injury which were then included in a second logistic regression to test their association with injury, adjusting for discrimination and sociodemographics. Participants reported a work-related injury (42%) and experiences of discrimination (81%). Discrimination was associated with injury in the first model (aOR = 2.25, p = 0.049), and discrimination attributed to immigration status was associated with injury in the second model (aOR = 5.04, p = 0.019). Injury prevention programs should account for perceived mistreatment to reduce LDL risk for injury at work.

Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy.

Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-19, combined with non-invasive ventilation, are known to sometimes determine acute liver injury. Although liver damage associated with COVID-19 is often transient and can resolve without any special treatment, it is important to understand the underlying mechanisms, particularly to better treat its more severe forms.

Evaluation of Causes and Effects of Fire and Other Safety Incidents in Readymade Garment Industry of Bangladesh

The readymade garment industry in Bangladesh is one of the foremost significant export-oriented industries, but it faces issues in ensuring worker safety. Industrial accidents threaten workplace safety, which is additionally amongst the foremost critical challenges in the world's industries. The objectives of this paper are to explore the numerous lethal incidents in the industry in Bangladesh and also explore the causes for these lethal incidents with the effect of those incidents. This paper aims to present a case study of the working conditions of readymade garment industries in Bangladesh and the case study presented past and running unsafe working conditions in the industry of violations of human rights and the high prevalence of injuries on duty by the workers. Differing kinds of causation in the recent decade have made the Bangladeshi garment industry ambiguous. Among 4,560 garment industries, 237 lethal incidents happened and that ratio was 5.2% during the last 31 years (1990-2020). Almost 237 lethal incidents, 94.09% incidents occurred by fire and only 1.27% incidents were caused by building collapse and 3.38% incidents were caused by boiler burst and another 1.27% by other different incidents. The total number of harmed people was 6,870 of which 1,689 people were injured and 5,181 people died, also the highest incident happened from 2011 to 2015 when 3,800 people were injured and 1,287 people died. This paper will investigate around for the causes of the various incidents and can expose the precautionary measure for those problems in the fashion industry which affected their sustainability and profitability.