Human papillomavirus (HPV) exhibits specific tropism for squamous epithelium and therefore contributes to the development of many benign, potentially malignant, and malignant epithelial lesions. The benign HPV-related lesions of the oral cavity comprise verruca vulgaris, squamous papilloma, condyloma acuminatum and multifocal epithelial hyperplasia. Oral squamous papilloma is most common in people of various ages. Purpose: To determine the structure, clinical features and morphological signs of oral squamous papilloma in patients of different sex and age. Materials and methods. For the period of 2020-2023, 18 people with oral papilloma (papillomatosis) aged 15 to 70 years were examined. In 12 patients, papilloma was removed by conventional surgery, in 6 patients – using a high power diode laser. Pathohistological evaluation of excisional biopsy and identification/genotyping of HPV DNA by REAL TIME PCR was carried out. Results. Squamous papilloma dominates in the structure of HPV-related benign oral lesions (88.8%). Among patients with papiloma, the majority are women (72.2%) with an average age of 29.3±4.0 years. The average age of men with papilloma is 52.2±5.8 years. By localization in the oral cavity, papillomas are most often found on the gingiva (43.75%), as well as on the tongue (25%), on the soft palate (18.75%), on the mucous membrane of the upper lip (6.25%) and cheek (6.25%). The average papilloma size by diameter was 0.71±0.06 cm. Pathomorphological confirmation of the impact of HPV on the development of oral squamous papilloma, namely the presence of coylocytes, was obtained in 31.3% of excision biopsies. Hyperkeratosis of the covering epithelium was found in 5 patients (27.7%), and this condition is defined as «keratopapiloma». In 6 women (33.3%), the presence of various types of HPV was detected by PCR, including high oncogenic risk (HPV-16, 18, 66, 68). Conclusion. Oral squamous papilloma, associated with high oncogenic risk HPV, as well as keratopapilloma in heavy smokers, should be considered a precancerous disease of the oral mucosa with a high risk of malignancy. Key words: human papillomavirus, papillomavirus infection, oral squamous papilloma, keratopapiloma, laboratory diagnostics, oral mucosa, risk of malignancy
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