Abstract Background Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) characterized by transmural granulomatous inflammation, skip lesions, and a relapsing-remitting course, potentially affecting the entire gastrointestinal tract. Patients with chronic illness are at an increased risk for traumatic stress because of the medical trauma. Previous evidence suggests that many patients perceive the chronic nature of the disease and related diagnostics and therapeutic procedures as traumatic events. Initial studies on post-traumatic stress (PTS) in patients with IBD have found that approximately one-third of patients may experience significant PTS symptoms, including flashbacks, nightmares, hypervigilance, disrupted sleep, and low mood, potentially leading to the development of post-traumatic stress disorder (PTSD). This study aims to explore the moderating role of adverse childhood experiences (ACEs) in the link between CD activity and PTSD symptoms. Methods In a cross-sectional design, the revised Impact of Event Scale (IES-R) and the ACEs Questionnaire were administered to consecutive CD outpatients at Policlinico A. Gemelli in Rome. Disease activity was assessed with the Harvey-Bradshaw Index (HBI). Data were analyzed using Pearson correlation coefficients and moderated regression models in SPSS (version 27). Results A total of 172 CD patients were included in the study, of whom 152 completed the IES and 148 also completed the ACEs questionnaire. Forty-eight patients (31.2%) exhibited a score of 33 or more on the IES-R, suggestive of PTSD. Correlation analyses revealed that ACEs scores correlated significantly with all subscales of the IES-R: intrusion (r=.405, p< .001), avoidance (r=.348, p< .001), and hyperarousal (r= .363, p< .001). Moreover, patients with higher ACEs had significantly more severe disease activity (r= .272, p< .001). Notably, the highest scores of ACEs were observed for the items related to feeling undervalued and ignored by one’s family. Further results from a hierarchical regression analysis demonstrated that the relationship between CD activity and the overall IES- R score was significantly stronger among patients with high ACEs scores (b= .21, p < .001) compared to those with medium (b= .12, p= .005) or low scores (b=.06, p =.291). Conclusion Our study revealed that ACEs play a moderating role in the relationship between CD disease activity and the development of PTS symptoms. Patients with higher PTS symptoms and more ACEs are less likely to achieve remission and may require increased use of gastroenterology services. These findings underscore the importance of a psychological assessment to enhance the management of these patients. Intervention trials to mitigate PTS symptoms in patients with IBD are warranted.
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