You have accessJournal of UrologyKidney Cancer: Localized (V)1 Apr 20131793 PROGNOSTIC SIGNIFICANCE OF PLATELET DERIVED GROWTH FACTOR-β RECEPTOR IN LOCALIZED CLEAR CELL RENAL CELL CARCINOMA Sejun Park, Myungsun Shim, Dalsan You, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, and Hanjong Ahn Sejun ParkSejun Park Seoul, Korea, Republic of More articles by this author , Myungsun ShimMyungsun Shim Seoul, Korea, Republic of More articles by this author , Dalsan YouDalsan You Seoul, Korea, Republic of More articles by this author , Cheryn SongCheryn Song Seoul, Korea, Republic of More articles by this author , Bumsik HongBumsik Hong Seoul, Korea, Republic of More articles by this author , Jun Hyuk HongJun Hyuk Hong Seoul, Korea, Republic of More articles by this author , Choung-Soo KimChoung-Soo Kim Seoul, Korea, Republic of More articles by this author , and Hanjong AhnHanjong Ahn Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2843AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The rate of recurrence is high in advanced renal cell carcinoma (RCC) after nephrectomy, while relatively very low in localized RCC. The prognostic factors of recurrence have been not investigated well in localized RCC except tumor stage and grade. We analyzed the angiogenic proteins and their receptor as the predictor of recurrence in patients with localized clear cell RCC after nephrectomy. METHODS The data of 758 patients with pT1/pT2N0 clear cell RCC undergoing radical or partial nephrectomy were prospectively collected. The expressions of vascular endothelial cell growth factor (VEGF), VEGF receptor (VEGFR), PDGF-β, and PDGF-β receptor (PDGFR-β) were assessed routinely by immunohistochemical assay in tumor specimen since 2007. We analyzed the predictor of recurrence in patients with RCC after nephrectomy. Median follow-up was 24.6 month (mean 25.7 month). RESULTS The mean age of the patients was 55 years. Radical nephrectomy was performed in 390 patients (51.5%) and partial nephrectomy in 368 patients (48.5%). The pathological T1a, T1b, and T2 were 67.8%, 25.3%, and 6.9%, respectively. Overall 3-year recurrence free survival (RFS) was 94.0%. In univariate analysis, pathological T stage was the prognostic factor of recurrence (The 3-year RFS; 97.9% for pT1a, 90.1 % for pT1b, and 69.9 % for pT2, p<0.001) along with age (p=0.002). Furthermore, high expression of PDGF-β or PDGFR-β increased the risk of recurrence (p=0.048 and p=0.033), while VEFG and VEGFR were not associated with recurrence. In multivariate analysis, PDGFR-β was an independent prognostic factor of recurrence (HR 2.693, p=0.014) along with age and pT stage (p=0.02, p=0.013). CONCLUSIONS High expression of PDGFR-β increased the risk of recurrence independently in localized RCC after nephrectomy. PDGFR-β may be considered not only the prognostic factor but a possible target for adjuvant therapy after nephrectomy. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e736-e737 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sejun Park Seoul, Korea, Republic of More articles by this author Myungsun Shim Seoul, Korea, Republic of More articles by this author Dalsan You Seoul, Korea, Republic of More articles by this author Cheryn Song Seoul, Korea, Republic of More articles by this author Bumsik Hong Seoul, Korea, Republic of More articles by this author Jun Hyuk Hong Seoul, Korea, Republic of More articles by this author Choung-Soo Kim Seoul, Korea, Republic of More articles by this author Hanjong Ahn Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...