In this paper, quaternion-valued high-order Hopfield neural networks (QVHHNNs) with time-varying delays are considered. Theoretically, a QVHHNN can be separated into four real-valued systems, forming an equivalent real-valued system. By using a novel continuation theorem of coincidence degree theory and constructing an appropriate Lyapunov function, some sufficient conditions are derived to guarantee the existence and global exponential stability of anti-periodic solutions for QVHHNN, which are new and complement previously known results.