To examine the effectiveness of the FIFA 11+ in reducing injury in futsal players. Ninety-one male futsal players from six amateur futsal clubs were recruited and assessed for eligibility, and 71 were randomized to the 11+ group (n=37, age: 27.0±5.1years) and a control group (n=34, age: 26.0±5.1years). The 11+ program was executed twice a week for 20weeks, separated by a 10-week period where both groups executed their regular warm-up. Data on match, training exposure, and injuries were recorded during the regular season. The players sustained a total of 58 injuries during the futsal regular season, with 24 injuries in the 11+ group and 34 injuries in the control group; the overall incidence of injuries per 1000 player-hours was significantly higher in the control group (11.6 vs 6.5; mean difference (95% CI) -5.1 (-9.1 to -1.1), P=.014). The 11+ group had a significantly lower incidence of acute (11.2 vs 5.7; -5.5 (-9.4 to -1.6), P=.007) and lower limb (8.7 vs 4.4; -4.2 (-8.1 to -0.4), P=.032) injuries per 1000 player-hours. Players from the control group had a higher number of days injured (20.4±17.3 vs 10.5±9.1, P=.036). The FIFA 11+ is an injury prevention program suited for injury reduction in amateur futsal players, as it reduces the incidence of overall, acute, and lower limb injuries during the season.