The search for alternative biomass energy forms has centered on two approaches: (1) production of cellulose fiber in biomass of low net energy value per unit weight, such as wood and bagasse, and (2) hydrocarbons of high net energy value per unit weight for use as chemical feedstocks and substitutes for petroleum. Major plant chemical products include oleoresin from pine ( Pinus elliottii Engelm., P. palustris Mill.), rubber from the rubber tree ( Hevea brasiliensis Muell.), and guayule shrub ( Parthenium argentatum Gray) and sugar from sugarcane ( Saccharum spp.). Genetic selections with lower natural yields tend to respond the most to bioregulators, and yields after treatment may equal those of the best selections also receiving the treatment. Ethylene may be a unifying natural bioregulator that can increase deposition of biomass chemicals in all four of these systems. The underlying success of the bioregulators is that assimilates are partitioned into extractives and sugar instead of vegetative growth. Examples include the use of paraquat, diquat, and 2-chloroethylphosphonic acid (CEPA) for stimulating the synthesis of oleoresin, CEPA for prolonging the flow of rubber and increasing rubber synthesis in the rubber tree, and triethylamines of chlorinated phenoxy compounds for stimulating rubber production in guayule. In sugarcane, gibberellic acid (GA 3) increases internodal elongation. Glyphosate, CEPA and other regulators increase the deposition of sucrose, diquat and CEPA inhibit flowering, and paraquat desiccates leaves just prior to harvest to facilitate leaf removal or burning just prior to harvest. The cellular compartmentalization for the synthesis of these plant chemicals is unique for each species, and dictates cultural and harvest techniques. Oleoresin is produced in the epithelial cells of resin canals and parenchyma of rays. Hevea rubber is produced in articulated laticifers. Hevea rubber and pine oleoresin are obtained by stripping away bark at various intervals during the year. The main source of guayule rubber is bark parenchyma and it is obtained by grinding the shrub, and coagulating and extracting the rubber. Sucrose is synthesized in the cytosol, stored in plastids and obtained by harvesting the cane and crushing it. The mode of action and pathways for the success of these physiological regulators are discussed.