Signatures of the formation of a strongly interacting thermalized matter of partons have been observed in nucleus-nucleus, proton-nucleus, and high-multiplicity proton-proton collisions at LHC energies. Strangeness enhancement in such ultra-relativistic heavy-ion collisions is considered to be a consequence of this thermalized phase, known as quark-gluon plasma (QGP). Simultaneously, proper modeling of hadronic energy fraction in interactions of ultra-high energy cosmic rays (UHECR) has been proposed as a solution for the “muon puzzle”, an unexpected excess of muons in air showers. These interactions have center-of-mass collision energies of the order of energies attained at the LHC or even higher, indicating that the possibility of a thermalized partonic state cannot be overlooked in UHECR-air interactions. This work investigates the hadronic energy fraction and strangeness enhancement to explore QGP-like phenomena in UHECR-air interactions using various high-energy hadronic models. A core-corona system with a thermalized core undergoing statistical hadronization is considered through the EPOS LHC model. In contrast, PYTHIA 8, QGSJET II-04, and SYBILL 2.3d consider string fragmentation without thermalization. We have found that EPOS LHC gives a better description of strangeness enhancement as compared to other models. We conclude that adequately treating all the relevant effects and further retuning the models is necessary to explain the observed effects.