High Migration Rates Research Articles

The frequency of wing damage in a migrating butterfly.

The ability to fly is crucial for migratory insects. Consequently, the accumulation of damage on the wings over time can affect survival, especially for species that travel long distances. We examined the frequency of irreversible wing damage in the migratory butterfly Vanessa cardui to explore the effect of wing structure on wing damage frequency, as well as the mechanisms that might mitigate wing damage. An exceptionally high migration rate driven by high precipitation levels in their larval habitats in the winter of 2018-2019 provided us with an excellent opportunity to collect data on the frequency of naturally occurring wing damage associated with long-distance flights. Digital images of 135 individuals of V. cardui were collected and analyzed in Germany. The results show that the hindwings experienced a greater frequency of damage than the forewings. Moreover, forewings experienced more severe damage on the lateral margin, whereas hindwings experienced more damage on the trailing margin. The frequency of wing margin damage was higher in the painted lady butterfly than in the migrating monarch butterfly and in the butterfly Pontia occidentalis following artificially induced wing collisions. The results of this study could be used in future comparative studies of patterns of wing damage in butterflies and other insects. Additional studies are needed to clarify whether the strategies for coping with wing damage differ between migratory and nonmigratory species.

Modulatory activity of ADNP on the hypoxia‑induced angiogenic process in glioblastoma.

Glioblastoma multiforme (GBM) is a brain cancer with a poor prognosis that affects adults. This is a solid tumor characterized by a high rate of cell migration and invasion. The uncontrolled cell proliferation creates hypoxic niches in the tumor mass, which leads to the overexpression of hypoxia‑inducible factors (HIFs). This induces the activation of the vascular endothelial growth factor (VEGF), which is responsible for uncontrolled neoangiogenesis. Recent studies have demonstrated the anti‑invasive effect of pituitary adenylate cyclase‑activating peptide (PACAP) in GBM. PACAP effects on the central nervous system are also mediated through the activity‑dependent neuroprotective protein (ADNP) activation. To date, no evidence exists regarding its role in GBM. Therefore, the ADNP involvement in GBM was investigated. By analyzing ADNP expression in a human GBM sample through confocal microscopy, a high ADNP immunoreactivity was detected in most glial cells and its predominant expression in hypoxic areas overexpressing HIF‑1α was highlighted. To investigate the role of ADNP on the HIF‑VEGF axis in GBM, a human U87MG GBM cell line was cultured with a hypoxic mimetic agent, deferoxamine, and cells were treated with the smallest active fragment of ADNP, known as NAP. The protein expression and distribution of HIF‑1α and VEGF was detected using western blot analysis and immunofluorescence assay. Results demonstrated that ADNP modulates the hypoxic‑angiogenic pathway in GBM cells by reducing VEGF secretion, detected through ELISA assay, as well as modulating their migration, assessed through wound healing assay. Although deeper investigation is necessary, the present study suggested that ADNP could be involved in PACAP anti‑invasive effects in GBM.

Analysis of per capita contributions from a spatial model provides strategies for controlling spread of invasive carp

AbstractMetapopulation models may be applied to inform natural resource management to guide actions targeted at location‐specific subpopulations. Model insights frequently help to understand which subpopulations to target and highlight the importance of connections among subpopulations. For example, managers often treat aquatic invasive species populations as discrete populations due to hydrological (e.g., lakes, pools formed by dams) or jurisdictional boundaries (e.g., river segments by country or jurisdictional units such as states or provinces). However, aquatic invasive species often have high rates of dispersion and migration among heterogenous locations, which complicates traditional metapopulation models and may not conform to management boundaries. Controlling invasive species requires consideration of spatial dynamics because local management activities (e.g., harvest, movement deterrents) may have important impacts on connected subpopulations. We expand upon previous work to create a spatial linear matrix model for an aquatic invasive species, Bighead Carp, in the Illinois River, USA, to examine the per capita contributions of specific subpopulations and impacts of different management scenarios on these subpopulations. Managers currently seek to prevent Bighead Carp from invading the Great Lakes via a connection between the Illinois Waterway and Lake Michigan by allocating management actions across a series of river pools. We applied the model to highlight how spatial variation in movement rates and recruitment can affect decisions about where management activities might occur. We found that where the model suggested management actions should occur depend crucially on the specific management goal (i.e., limiting the growth rate of the metapopulation vs. limiting the growth rate of the invasion front) and the per capita recruitment rate in downstream pools. Our findings illustrate the importance of linking metapopulation dynamics to management goals for invasive species control.

Migration of Energetic Plasticizer in Advanced Energetic Composite Propellant Grains

AbstractStudies on the migration of nitrate ester plasticizers from advanced energetic nitrate ester plasticized polyester polyol (NEPE) propellants stored at 27o and 55 °C using HPLC showed that the nitrate ester content is depleting from the bulk of the propellant with time, upto 125 weeks, till equilibrium is reached. Diffussion coefficient for migration of nitrate ester estimated by Fick's 2nd law of diffusion reveals that the magnitude of estimated diffussion coefficient is high for the propellant sample stored at elevated temperature as compared to the samples stored at ambient condition, indicating the higher rate of plasticizer migration at high temperature. Also, the estimated diffussion coefficient for NG migration is higher than that for BTTN which is inline with its higher rate of migration. The diffussion coefficients have also been estimated by the tensile strength data of the stored propellants and its magnitude is marginally higher than the one estimated by the physical phenomenon of plasticizer migration as described by Fick's law. Hence it can be inferred that along with the post cure reaction, the plasticizer migration is also responsible for toughening of propellant during storage.

Expansion of fibroblast cell sheets using a modified MEEK micrografting technique for wound healing applications

Cell sheet engineering, a scaffold-free approach to fabricate functional tissue constructs from several cell monolayers, has shown promise in tissue regeneration and wound healing. Unfortunately, these cell sheets are often too small to provide sufficient wound area coverage. In this study, we describe a process to enlarge cell sheets using MEEK micrografting, a technique extensively used to expand skin autografts for large burn treatments. Human dermal fibroblast cell sheets were placed on MEEK’s prefolded gauze without any use of adhesive, cut along the premarked lines and stretched out at various expansion ratios (1:3, 1:6 and 1:9), resulting in regular distribution of many square islands of fibroblasts at a much larger surface area. The cellular processes essential for wound healing, including reattachment, proliferation, and migration, of the fibroblasts on expanded MEEK gauze were superior to those on nylon dressing which served as a control. The optimal expansion ratio with the highest migration rate was 1:6, possibly due to the activation of chemical signals caused by mechanical stretching and an effective intercellular communication distance. Therefore, the combination of cell sheet engineering with the MEEK micrografting technique could provide high quality cells with a large coverage area, which would be particularly beneficial in wound care applications.

Assessment of meander‐bend migration of a major distributary of the Ganges River within Bangladesh

AbstractThe Arial Khan is an important distributary river of the Ganges River within Bangladesh. The river is meandering, and channel shifting and bend migration are common. This study investigates the bend‐scale morphology of 37 characteristic bends of the river using Landsat imageries, river bathymetries, and hydrological data. The morphological changes of the river are correlated with the temporal shifting of its offtake, which in turn is linked to the dynamic behavior of the river in terms of sinuosity, bend geometry, and bend migration. Alterations in the offtake location, bed elevation, and in‐front bar formation are found to control the flow to the river. The sinuosity varies from 1.62 to 1.95 and is linked to the shifting of its offtake. The lifetimes of the bends increase from upstream to downstream with an average lifetime of 24 years. The radii of the bends vary from upper to lower reaches with an average radius of 921 m. The upper reach is more migration prone, and its average migration rate (108 m/year) is more than twice the other two reaches. A higher migration rate of 70–80 m/year is found for the river during 1981–1999 compared to the rates of 45–50 m/year for the rest of the study periods (1972–2021). An envelope curve depicting the relation between the relative curvature of a bend and its migration rate for the river is also developed. The overall morphology from 1972 to 2021 indicates that a significant increase in sinuosity and a reduction in river width and aspect ratio have occurred. The migration rate has declined slightly and the frequency of bend cutoffs has reduced notably in recent years. Nonetheless, due to the high rates of migration, there exists potential future threat to riverbank erosion in some critical bends, and hence damages to land, property, structure, and project on the vulnerable banks.

Mortality analysis of endovascular aneurysm sealing versus endovascular aneurysm repair

BackgroundEndovascular aneurysm sealing (EVAS), using the Nellix endovascular aneurysm sealing system, has been associated with high reintervention and migration rates. However, prior reports have suggested that EVAS might be related to a lower all-cause mortality compared with endovascular aneurysm repair (EVAR). In the present study, we examined the 5-year all-cause mortality trends after EVAS and EVAR. MethodsWe compared the 333 EVAS patients in the EVAS-1 Nellix U.S. investigational device exemption trial with 16,497 infrarenal EVAR controls from the Vascular Quality Initiative, treated between 2014 and 2016, after applying the exclusion criteria from the investigational device exemption trial (ie, hemodialysis, creatinine >2.0 mg/dL, rupture). As a secondary analysis, we stratified the patients by aneurysm diameter (<5.5 cm and ≥5.5 cm). We calculated propensity scores after adjusting for demographics, comorbidities, and anatomic characteristics and applied inverse probability weighting to compare the risk-adjusted long-term mortality using Kaplan-Meier and Cox regression analyses. ResultsAfter weighting, the EVAS group had experienced similar 5-year mortality compared with the controls from the Vascular Quality Initiative (EVAS vs EVAR, 18% vs 14%; hazard ratio [HR], 1.1; 95% confidence interval [CI], 0.71-1.7; P = .70). The subgroup analysis demonstrated that for patients with an aneurysm diameter of <5.5 cm, EVAS was associated with higher 5-year mortality compared with EVAR (19% vs 11%; HR, 2.4; 95% CI, 1.7-4.7; P = .013). In patients with an aneurysm diameter of ≥5.5 cm, EVAS was associated with lower mortality within the first 2 years (2-year mortality: HR, 0.29; 95% CI, 0.13-0.62; P = .002). However, compared with EVAR, EVAS was associated with higher mortality between 2 and 5 years (HR, 1.9; 95% CI, 1.2-3.0; P = .005), with no mortality difference at 5 years (18% vs 17%; HR, 0.82; 95% CI, 0.4-1.4; P = .46). ConclusionsWithin the overall population, EVAS was associated with similar 5-year mortality compared with EVAR. EVAS was associated with higher mortality for those with small aneurysms (<5.5 cm). For those with larger aneurysms (≥5.5 cm), EVAS was initially associated with lower mortality within the first 2 years, although this advantage was lost thereafter, with higher mortality after 2 years. Future studies are required to evaluate the specific causes of death and to elucidate the potential beneficial mechanism behind sac obliteration that leads to this potential initial survival benefit. This could help guide the development of future grafts with better proximal fixation and sealing that also incorporate sac obliteration.

Analysis of risks factors associated with construction projects in urban wetlands ecosystem

ABSTRACT Within some developing countries, wetlands have long been regarded as dumping grounds. However, there has been a gradual paradigm shift in societal attitudes towards recognising their importance as landscape features that provide benefits for humans and wildlife. Unfortunately, construction activities have continually plagued their existence. Therefore, this present research examines the risks factors associated with construction projects in wetlands ecosystem, using Ghana as a case study. A quantitative research strategy leaning towards the positivist paradigm was adopted. A structured survey was developed to collect data from key stakeholders. Purposive sampling was employed to recruit construction experts in the Kumasi Metropolis, with a total of 78 experts agreeing to participate. Relative Importance Index (RII), Mean Score Ranking and a One-Sample T-Test were used to analyse primary data collected. The findings revealed that the key driving forces spurring construction projects in wetlands were rapid urbanisation; high rate of migration; and scarcity of land for development. Critical risks factors associated with construction projects in wetlands were identified as cost overruns; exploitation of biological resources; and water pollution. Finally, the findings also showed that the most critical detrimental effects of construction projects in wetlands were the destruction of aquatic and terrestrial lives; loss of flood control capability; and deterioration of wetland water quality. The study recommends the protection and conservation of wetlands environments through systematized enactment and enforcement of environmental protection regulations by government and non-governmental institutions. This would ensure the preservation of important biodiversity and aid with pollution control and flood protection.

DIMDP: A Driving Intention-Based MDP Service Migration Model under MEC/MSCN Architecture

Service migration is one of the key topics of Internet of Vehicles (IoV). MEC (mobile edge computing), which is carried on the roadside unit (RSU), could serve as a service provider and provide a V2I (vehicle to infrastructure) cooperation service. To solve the high migration rate caused by the vehicle’s high mobility feature, MSCN (mobile secondary computing node) framework is defined. To study service migration features under the MSCN framework further, in this paper, road vehicle’s motion features, e.g., driving intention and regional traffic condition, are introduced to construct the Markov decision model, which is used to explain the service migration decision procedure, while DIMDP (driving intention-based MDP) is defined. Corresponding cost functions are defined, while the optimal object is given. A two-way road scenario is selected as a typical scenario. NS3 platform is employed to fulfill the simulation process. Simulation results show that the proposed service migration strategy performs well and is intensive to vehicle density change.

Detecting zoonotic and non-zoonotic pathogens in livestock and their ticks in Corsican wetlands.

Corsica is a large French island in the Mediterranean Sea with high human and animal migration rates, especially near wetlands where these migrations are particularly frequent. Among the livestock populations, cattle and sheep are widely present all across the entire Mediterranean region. Trade can be responsible for the circulation of numerous pathogens and their vectors, thereby representing a health and economic threat for the livestock industry. The objective of our study was to investigate the presence of pathogens in cattle and sheep farms in the wetlands of Corsica using a high-throughput screening technique. In our study, blood samples and ticks were collected from cattle and sheep in 20 municipalities near Corsican wetlands to screen for the presence of various types of pathogens. The samples were processed using a high-throughput screening technique based on real-time microfluidic PCR: 45 pathogens were screened in 47 samples simultaneously. A total of 372 cattle and 74 sheep were sampled, and 444 ticks were collected from cattle. Out of the eight tick species detected, the main one was Rhipicephalus bursa (38.7% of the ticks collected). From cattle blood samples, one species and two genera were found: Anaplasma marginale, Trypanosoma sp. and Babesia sp. in respectively 61.5%, 58.3% and 12.2% of the cattle blood samples. From sheep blood samples, 74.3% were positive for Anaplasma sp, 2.7% for Anaplasma ovis and 1.4% for Anaplasma capra. This is the first report of A. ovis DNA in blood samples from sheep in Corsica. Out of 444 the tick samples, 114 were positive: 77.2% for Rickettsia aeschlimannii, 20.2% for Rickettsia sp., 3.5% for Babesia sp. and 1.8% for Anaplasma sp. Among them, 2.7% were co-infected with R. aeschlimannii and Babesia sp. Our results confirm the extent of possible circulation of different pathogens near Corsican wetlands, not only in ticks collected from livestock but also directly in cattle and sheep, with two (Trypanosoma sp. and Babesia sp.) being detected for the first time in cattle, one for the first time in sheep (A. ovis) and one for the first time in Corsica (A. capra).

Skin microbiota interact with microbes on office surfaces.

The indoor environment is recognized as a potential contributor to human health impacts through resident microbiomes. Indoor surface microbial communities are formed from several sources, environmental and anthropogenic. In this study, we characterized the bacterial and fungal communities from various sources typical of a working office environment including dust, fingers, and computer keyboards and mice. The composition of the dust bacterial community was significantly different from the other tested surfaces (P<0.05), whereas the dust fungal community was only significantly different from fingers (P<0.05). Bacterial and fungal communities were both shaped by deterministic processes, and bacterial communities had a higher migration rate. Results of a network analysis showed that the microbial community interactions of keyboards and mice were mainly competitive. Fast expectation-maximization microbial source tracking (FEAST) identified the sources of>70% of the keyboard and mouse microbial communities. Biomarkers for each sample types were identified by LDA Effect Size (LEfSE) analysis, some of which were soil-derived and potential anthropogenic pathogens, indicating the potential for exchange of microbes among outdoor, human and indoor surfaces. The current study shows that the source of microorganisms at the office interface is highly traceable and that their migration is linked to human activity. The migration of potentially pathogenic microbes were identified, emphasising the importance of personal hygiene.

Patterns of microbial communities and their relationships with water quality in a large-scale water transfer system.

Revealing the patterns and their mechanisms of microbial community in water transfer projects, especially in inter-basin water transfer projects, is the premise of biohazard warning, water quality monitoring and sustainable management of water resources. Using a river and impounded lakes from the eastern route of South-to-North Water Transfer project as a model system, we studied the diversity and assembly patterns of bacterial communities in artificially connected ecosystems and their influencing factors. Our results showed that water quality improved during the water transfer period (WTP). Further, the latitudinal pattern of bacterioplankton was reversed, which was mainly due to the change of evenness caused by water transfer and had no significant correlation with water quality parameters. Importantly, the spatial heterogeneity of the bacterial communities decreased during the WTP, and the differences in the communities between the impounded lakes and river was more significant in the non-water transfer period (NWTP) than in the WTP, which was the result of water transfer and water quality. Overall, bacterial community was largely shaped by stochastic processes. The bacterial communities had a higher migration rate during the WTP than during the NWTP. We believe that the water transfer increased the risk of biological homogenization while improving water quality. Combined, our work systematically discusses the microbial community pattern and mechanism in the inter-basin water transfer project, providing theoretical support for inter-basin water transfer project planning management and ecological environment protection.

Planform Dynamics and Cut-Off Processes in the Lower Ucayali River, Peruvian Amazon

The Ucayali River is one of the most dynamic large rivers in the world, with high rates of channel migration regularly producing cutoffs. In the lower portion of the Ucayali River, before its confluence to the Marañon River where the Amazon River is born, the increase in water and sediment discharge triggers bends with secondary channels (transitional stage from purely meandering to anabranching), which influence the planform migration rates and patterns of the sinuous channels. Based on remote sensing analysis, a comparison of planform dynamics of bends with and without secondary channels is presented. For the case of a bend with secondary channels (Jenaro Herrera, JH), detailed field measurements for bed morphology, hydrodynamics, bed and suspended load are performed for low-, transitional- and high-flow conditions (August, February and May, respectively). Additionally, a two-dimensional depth average hydraulic model is utilized to correlate observed migrating patterns with the hydrodynamics. Results indicate that the secondary channels have disrupted typical planform migration rates of the main meandering channel. However, at high amplitudes, these secondary channels reduce their capacity to capture flow and start a narrowing process, which in turn increases migration rates of the main channels (meandering reactivation process), suggesting that an imminent cutoff along the JH bend is underway by pure lateral migration or by the collapse into the existing paleochannels.

Microwave Synthesized 2D WO3 Nanosheets for VOCs Gas Sensors.

As an n-type semiconductor material, tungsten oxide (WO3) has good application prospects in the field of gas sensing. Herein, using oxalic acid (OA), citric acid (CA) and tartaric acid (TA) as auxiliary agents, three homogeneous tungsten oxide nanosheets were prepared by the rapid microwave-assisted hydrothermal method. The potential exhaled gases of various diseases were screened for the gas sensitivity test. Compared with WO3-OA and WO3-TA, WO3-CA exhibits significant sensitivity to formaldehyde, acetone and various alkanes. Photoluminescence (PL) chromatography and photoelectric properties show that its excellent gas sensitivity is due to its abundant oxygen vacancies and high surface charge migration rate, which can provide more preferential reaction sites with gas molecules. The experiment is of great significance for the sensor selection of the large disease exhaled gas sensor array.

Fast charge separation and transfer strategy in polymeric carbon nitride for efficient photocatalytic H2 evolution: Coupling surface Schottky junctions and interlayer charge transfer channels

Reinforcing the charge separation and transfer in layered polymeric carbon nitride (PCN) is the key issue to enhance its photocatalytic activity but still remains very challenging. Herein, for the first time, the synergetic Pd single atoms (PdSAs) and carbon-supported Pd nanoparticles (NPs) are introduced into the interlayer and surface of layered PCN respectively to address this challenge. The PdSAs are in intimate contact with the adjacent PCN layers and serve as interlayer charge transfer channels, while the carbon-supported Pd NPs contribute to multistep PCN-carbon-Pd NPs Schottky junctions on PCN surface. Experiments and theoretical calculations demonstrate that such unique architectures provide intrinsic driving force to extract the electrons from PCN to outermost Pd NPs with high migration rate via vertical PdSAs channels. This directional charge transfer in PCN greatly expedite the separation of charge carriers in both inner and surface of PCN and simultaneously yield electron-rich Pd NPs active sites with optimized H2 adsorption energy, thus leading to improved intrinsic H2 evolution reaction kinetics. Consequently, the Pd/PCN2 performs ultrahigh photocatalytic H2 evolution rate of 83.34 mmol g−1 h−1 in the dispersed particulate system and 100.4 mmol h−1 m−2 in the film form under simulated sunlight. This work provides a new promising approach to engineer the spatial charge transfer behaviors for high-performance PCN-based photocatalysts.

Anti-pathogenic, anti-diabetic, anti-inflammatory, antioxidant, and wound healing efficacy of Datura metel L. leaves

Datura metel L. is an important medicinal plant of Solanaceae family which has extensive pharmacological properties. The present investigation was aimed to identify the presence of phytoconstituents and assess in vitro antibacterial, anti-biofilm, anti-diabetic, anti-inflammatory, antioxidant, cytotoxicity, and wound healing efficacy of D. metel leaves extract. Among different solvent extracts, methanolic extract showed higher amount of phenolic (124.61 ± 0.68 mg GAE/g), alkaloid (88.77 ± 1.01 mg AE/g), flavonoids (42.24 ± 0.18 mg QE/g), and tannins contents (38.72 ± 0.51 mg GAE/g). The extract exhibited not only significantly (P < 0.05) different antibacterial activities against pathogens tested but also showed maximum biofilm inhibition of 94, 88, and 92% against B. subtilis, MRSA, and E. coli, respectively. Anti-diabetic assay depicted 22.55 ± 0.62–79.41 ± 1.13% and 24.31 ± 1.47–72.59 ± 0.22% of α-amylase and α-glucosidase inhibition abilities of methanolic extract, respectively at varied concentrations. The methanolic extract showed potential anti-inflammatory effect (P < 0.05) by showing 28.11 ± 0.13, 34.94 ± 1.11, 55.73 ± 0.42, 73.28 ± 0.72, and 92.62 ± 1.33% of inhibition of protein denaturation at different concentrations with an IC50 value of 52.45 µg/mL. The extract revealed significant (P < 0.05) rate of ABTS scavenging, DPPH degradation, and reducing power assay in a concentration dependent manner. The cytotoxicity assay was demonstrated on L929 mouse fibroblast cell line and found > 90% of cell viability in the presence of methanolic extract, thereby indicating its non-toxicity effect. Wound healing assay indicated that methanolic extract at 50 µg/mL closed 100% of wound gap after 24 h with high rate of migration and proliferation. Furthermore, GC–MS chromatogram revealed the presence of several components in methanolic extract, including neophytadiene, hexadecanoic acid, and hentriacontane as principal phytoconstituents. In conclusion, methanolic extract of D. metel leaves could be used as potent therapeutic agent not only for treating metabolic diseases but also superficial chronic diabetic wounds.

Coastal dunes migration over the Itaúnas district - Espírito Santo, humid tropical coast of Southeast Brazil

The migration of transgressive coastal dunes over urban and farming areas is commonly observed in the semi-arid northern coast of the Brazilian northeast. However, it is unusual in the humid tropical coast of southeastern Brazil. This paper aims to investigate the aeolian dynamics and the drivers of the burial process over the Itaúnas District, Espírito Santo State landscape, by transgressive coastal dunes. Methodological procedures consist of remote sensing techniques, geoprocessing, wind regime simulations, and mathematical calculations of migration rate parameters. Satellite images were georeferenced using ArcGIS 10.3 software and wind regime information was simulated using HYSPLIT software using wind reanalysis data. The results suggest a sediment transport rate of 44.98 kg/m/s, wind drift potential of 123.96 v.u. and dune migration rate estimated at 4.0 m/yr. It was found that the northern and western sectors of the studied dunefield have the highest migration rates towards the main access road, water resources and urban area. The values obtained are considered significant because it is a coastal segment subjected to a humid tropical climate.

High rates of treatment stage migration for early hepatocellular carcinoma and association with adverse outcomes: An Australian multicenter study.

Background and AimThe rate of contraindications to percutaneous ablation (PA) for inoperable early hepatocellular carcinoma (HCC) and subsequent outcomes is not well described. We investigated the prevalence and outcomes of inoperable early HCC patients with contraindications to PA, resulting in treatment stage migration (TSM).MethodsBarcelona Clinic Liver Cancer (BCLC) 0/A patients diagnosed between September 2013 and September 2019 across five hospitals were identified. Primary endpoint was proportion of BCLC 0/A HCCs with contraindications to PA. Secondary endpoints included overall survival (OS), local tumor control (LTC), and recurrence‐free survival (RFS). The causal effects of PA versus TSM were assessed using a potential outcome means (POM) framework in which the average treatment effects (ATEs) of PA were estimated after accounting for potential selection bias and confounding.ResultsTwo hundred twenty patients with inoperable BCLC 0/A HCC were identified. One hundred twenty‐two patients (55.5%) had contraindications to PA and received TSM therapy, 98 patients (44.5%) received PA. The main contraindication to PA was difficult tumor location (51%). Patients who received TSM therapy had lower median OS (2.4 vs 5.3 years), LTC (1.0 vs 4.8 years), and RFS (0.8 vs 2.9 years); P < 0.001, respectively, compared with PA. The ATE for PA versus TSM yielded an additional 1.11 years (P = 0.019), 2.45 years (P < 0.001), and 1.64 years (P < 0.001) for OS, LTC, and RFS, respectively. Three‐year LTC after PA was suboptimal (65%).ConclusionOur study highlights high rates of contraindication to PA in early HCCs, resulting in TSM and poorer outcomes. The LTC rate for PA appears suboptimal despite being considered as curative therapy. Both findings support the exploration of improved treatment options for early HCCs.

Formulation of Wound Healing Transdermal Patch from Tubers Extract of Momordica Cymbalaria and its In-vitro Evaluation

Developing wound infection in type Ⅰ or Ⅱ diabetic people had risk complications like gangrene. Although there are enough antibiotic ointments or creams, still it needs physician dressing and continuous monitoring of wound. So, to make it simple and more effective, a combination of transdermal drug delivery route with herbal usage contribute in controlled release of medication with minimum undesirable side effects. And also help to treat wound infections by self-medication. This work is focused, to formulate wound healing transdermal patch for diabetics with Momordica cymbalaria tuber extract. A sequence of techniques was performed to analyse antioxidant content then Starch assay was performed In vitro to evaluate its healing efficacy, determine cytotoxicity using zebra fish embryos and artemia salina using hexane extract of tuber. Optimized combination is used to prepare Patch by solvent evaporation method then evaluated the patch by organoleptic and physico-chemical properties. The result proofs, the tuber extract had Strong Antioxidant activity whereas weak cytotoxicity showed in two concentration (25 and 50µg/ml) towards brine shrimp lethality assay and fish embryo toxicity. High migration rate found in 25µg/ml and 50µg/ml in scratch assay using Human Epidermal Keratinocytes. Evaluated the patch for its organoleptic and physico-chemical properties, it shows good result. As a final observation of the study, bio compounds present in tuber extract proved to enhance wound healing and could pave way as alternate to the synthetic wound healing patches owing to its ecofriendly, economical and herbal nature be natural replacement to hasten wound healing especially in diabetic patients.

Cu2O/Ti3C2T x nanocomposites for detection of triethylamine gas at room temperature

Triethylamine gas is one of the harmful volatile organic compounds for human health and the ecological environment. Therefore, in order to prevent the detrimental effects of triethylamine gas, it has greatly requirement to be accurately detected. Unfortunately, Cu2O has a low triethylamine gas response and slow recovery. Because of this, we prepared Cu2O/Ti3C2T x nanocomposites by a facile ultrasonication technique. Cu2O is uniformly dispersed on the surface and interlayers of multilayer Ti3C2T x to form a stable hybrid heterostructure. The optimized Cu2O/Ti3C2T x nanocomposite sensor’s response to 10 ppm triethylamine at room temperature is 181.6% (∣ R g-R a ∣/R a × 100%). It is 3.5 times higher than the original Cu2O nanospheres (52.1%). Moreover, due to the characteristics of high carrier migration rate and excellent conductivity of Ti3C2T x , the response recovery rate (1062 s/74 s) of Cu2O/Ti3C2Tx composites is greatly improved than pristine Cu2O (3169 s/293 s). In addition, Cu2O/Ti3C2T x nanocomposites sensor also shows excellent repeatability, outstanding selectivity, and long-term stability. Thus, the Cu2O/Ti3C2T x nanocomposites sensor has broad application prospects for detecting triethylamine gas at room temperature.