ABSTRACT Background Academic burnout is a concern among students. The research aimed to depict the current situation and examine several factors associated with academic burnout among students of Hanoi Medical University in 2023. Methods A cross sectional study was carried out on a sample of 300 randomly selected students from Hanoi Medical University. The study employed demographic questionnaires and the Maslach Burnout Inventory Student Survey (MBI-SS) to assess the level of burnout. Statistical analyses, including descriptive statistics and regression analysis, were performed to evaluate burnout-related factors. Results The study findings revealed that the overall prevalence of burnout was 16.33%. Factors associated with burnout syndrome included being female (OR = 0.42, 95% CI 0.19 −0.93) with a lower level of burnout than males, fourth-year students (OR = 0.06, 95% CI 0.01 −0.72) had a lower level of burnout compared to other academic years, and students pursuing pre-clinical courses (OR = 4.07, 95% CI 1.17 −14.29) had a higher level of burnout. Conclusion The study findings highlight that academic burnout is a noteworthy issue among students. Examining burnout-related factors, including gender, academic year, and field of study, can assist universities in developing specific interventions to support students in managing burnout and enhancing the quality of education.