The rational layout of tidal stream turbines (TSTs) is beneficial for making full use of tidal stream energy. It is essential to consider the wake radius and velocity distribution for determining the spacing between the TSTs. The wake is primarily affected by the turbulence intensity. The attenuation of turbulence results in the non-linear expansion of the wake. Additionally, the high turbulence in the near wake region inhibits the velocity deficit, which is more evident under high ambient turbulence intensity. Therefore, a radius and minimum velocity Jensen (RMV-Jensen) model is proposed to predict the wake radius and the wake velocity distribution downstream of a TST. The RMV-Jensen model consists of a radius block (R-Block) and a minimum velocity block (MV-Block). The R-Block is a piecewise exponential function based on the turbulence attenuation in the wake region, accurately describing the change of the wake expansion coefficient. The MV-Block is a wake minimum velocity model, and the inhibitory effect of turbulence on velocity deficit is considered for the first time. The RMV-Jensen model is applied to predict the wake distribution in the Zhoushan sea area. The prediction accuracy of the RMV-Jensen model is improved by 10%–20% compared to that of the classical Jensen model, according to the experimental results.