High-intensity Interval Sessions Research Articles

Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial.

A supervised intense aerobic exercise program improves the health of individuals with metabolic syndrome (MetS). However, it is unclear whether the timing of training within the 24h day would influence those health benefits. The present study aimed to determine the influence of morning vs. afternoon exercise on body composition, cardiometabolic health and components of MetS. One hundred thirty-nine individuals with MetS were block randomized into morning (AMEX; n=42) or afternoon (PMEX; n=59) exercise training groups, or a non-training control group (Control; n=38). Exercise training was comprised of 48supervised high-intensity interval sessions distributed over 16weeks. Body composition, cardiorespiratory fitness (assessed by ), maximal fat oxidation (FOmax ), blood pressure and blood metabolites were assessed before and after the intervention. Compared with the non-training Control, both exercise groups improved similarly body composition (-0.7% fat loss; P=0.002), waist circumference (-2.1 cm; P<0.001), diastolic blood pressure (-3.8mmHg; P=0.004) and (3.5mLkg-1 min-1 ; P<0.001) with no differences between training groups. AMEX, in comparison with PMEX, reduced systolic blood pressure (-4% vs. -1%; P=0.019), plasma fasting insulin concentration (-12% vs. -5%; P=0.001) and insulin resistance (-14% vs. -4%; P=0.006). Furthermore, MetS Zscore was further reduced in the AMEX compared to PMEX (-52% vs. -19%; P=0.021) after training. In summary, high-intensity aerobic exercise training in the morning in comparison to training in the afternoon is somewhat more efficient at reducing cardiometabolic risk factors (i.e. systolic blood pressure and insulin sensitivity). KEY POINTS: The effect of exercise time of day on health promotion is an area that has gained interest in recent years; however, large-scale, randomized-control studies are scarce. People with metabolic syndrome (MetS) are at risk of developing cardiometabolic diseases and reductions in this risk with exercise training can be precisely gauged using a compound score sensitive to subtle evolution in each MetS component (i.e. Z score). Supervised aerobic exercise for 16weeks (morning and afternoon), without dietary restriction, improved cardiorespiratory and metabolic fitness, body composition and mean arterial pressure compared to a non-exercise control group. However, training in the morning, without changes in exercise dose or intensity, reduced systolic blood pressure and insulin resistance further compared to when training in the afternoon. Thus, high-intensity aerobic exercise training in the morning is somewhat more efficient in improving the health of individuals with metabolic syndrome.

Impact of high-intensity interval hyperpnea on aerobic energy release and inspiratory muscle fatigue

Respiratory muscle endurance training reportedly has beneficial effects on whole-body endurance performance. We produced a novel high-intensity interval (HII) protocol and characterized the associated physiological responses and respiratory muscle fatigue. Peak oxygen uptake of respiratory muscle (V̇O2peakRM) was estimated during the respiratory incremental test. The HII session consisted of five 3-minute hyperpnea periods at 100%V̇O2peakRM interspersed with 2-minute periods at 40%V̇O2peakRM (25 min total). The high-intensity continuous (HIC) session involved a single time-to-end bout of hyperpnea at 100%V̇O2peakRM. The moderate-intensity continuous (MIC) session involved 25 min of hyperpnea at 60% of maximal voluntary ventilation. V̇O2RM was recorded continuously, and maximal inspiratory pressure (PImax) was assessed before and after the sessions. HII session: V̇O2RM gradually increased as the sets proceeded, whereas PImax decreased significantly. HIC session: V̇O2RM increased progressively, and the time to end was 6.5 ± 0.5 min. PImax decreased significantly. MIC session: V̇O2RM did not change for 25 min, and PImax remained unchanged. The duration of V̇O2RM at near- and supra-maximal levels in the HII session (10 ± 1 min) was longer than that in the HIC session (4 ± 1 min). The decrease in PImax was larger in the HII session (−12 ± 3 %) than MIC session (−4 ± 3 %). The HII protocol is characterized by a longer time to maximally stimulate the aerobic energy system of respiratory muscle than the HIC protocol and greater inspiratory muscle fatigue than the traditional MIC protocol. These results suggest that the HII protocol could enhance the efficacy of respiratory muscle training programs.

Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy.

Background: Chemotherapy treatment for breast cancer associates with well-documented cardiovascular detriments. Exercise has shown promise as a potentially protective intervention against cardiac toxicity. However, there is a paucity of evidence for the benefits of exercise on the vasculature. Objectives: This study aimed to determine the effects of chemotherapy on the vascular endothelium; and if there are protective effects of serological alterations elicited by an exercise training intervention. Methods and Results: 15 women participated in a 12-week home-based exercise intervention consisting of three high-intensity interval sessions per week. Human coronary artery endothelial cells (HCAEC) were exposed to physiological concentrations of 5-fluorouracil, epirubicin, cyclophosphamide (FEC) and docetaxel to determine a dose-response. Twenty-4hours prior to FEC and docetaxel exposure, HCAECs were preconditioned with serum collected pre- and post-training. Annexin V binding and cleaved caspase-3 were assessed using flow cytometry and wound repair by scratch assays. Chemotherapy exposure increased HCAEC Annexin V binding, cleaved caspase-3 expression in a dose-dependent manner; and inhibited wound repair. Compared to pre-training serum, conditioning HCAECs with post-training serum, reduced Annexin V binding (42% vs. 30%, p = 0.01) when exposed to FEC. For docetaxel, there were no within-group differences (pre-vs post-exercise) for Annexin V binding or cleaved caspase-3 expression. There was a protective effect of post-training serum on wound repair for 5-flurouracil (p = 0.03) only. Conclusion: FEC-T chemotherapy drugs cause significant damage and dysfunction of endothelial cells. Preconditioning with serum collected after an exercise training intervention, elicited some protection against the usual toxicity of FEC-T, when compared to control serum.

A 6-day high-intensity interval microcycle improves indicators of endurance performance in elite cross-country skiers.

The aim of this study was to compare the effects of a 6-day high-intensity interval (HIT) block [BLOCK, n = 12, maximal oxygen uptake (V̇O2max = 69. 6 ± 4.3 mL·min-1·kg-1)] with a time-matched period with usual training (CON, n = 12, V̇O2max = 69.2 ± 4.2 mL·min-1·kg-1) in well-trained cross-country (XC) skiers on physiological determinants and indicators of endurance performance. Furthermore, the study aimed to investigate the acute physiological responses, including time ≥90% of V̇O2max, and its associated reliability during repeated HIT sessions in the HIT microcycle. Before the 6-day HIT block and following 5 days of recovery after the HIT block, both groups were tested on indicators of endurance performance. To quantify time ≥90% of V̇O2max during interval sessions in the HIT block, V̇O2 measurements were performed on the 1st, 2nd, and last HIT session in BLOCK. BLOCK had a larger improvement than CON in maximal 1-min velocity achieved during the V̇O2max test (3.1 ± 3.1% vs. 1.2 ± 1.6%, respectively; p = 0.010) and velocity corresponding to 4 mmol·L-1 blood lactate (3.2 ± 2.9% vs. 0.6 ± 2.1%, respectively; p = 0.024). During submaximal exercise, BLOCK displayed a larger reduction in respiratory exchange ratio, blood lactate concentration, heart rate, and rate of perceived exertion (p < 0.05) and a tendency towards less energy expenditure compared to CON (p = 0.073). The ICC of time ≥90% V̇O2max in the present study was 0.57, which indicates moderate reliability. In well-trained XC skiers, BLOCK induced superior changes in indicators of endurance performance compared with CON, while time ≥90% of V̇O2max during the HIT sessions in the 6-day block had a moderate reliability.

Modeling the expenditure and reconstitution of distance above critical speed during two swimming interval training sessions.

In swimming, the speed-time relationship provides the critical speed (CS) and the maximum distance that can be performed above CS (D′). During intermittent severe intensity exercise, a complete D′ depletion coincides with task failure, while a sub-CS intensity is required for D′ reconstitution. Therefore, determining the balance D′ remaining at any time during intermittent exercise (D'BAL) could improve training prescription. This study aimed to 1) test the D'BAL model for swimming; 2) determine an equation to estimate the time constant of the reconstitution of D' (τD′); and 3) verify if τD′ is constant during two interval training sessions with the same work intensity and duration and recovery intensity, but different recovery duration. Thirteen swimmers determined CS and D′ and performed two high-intensity interval sessions at a constant speed, with repetitions fixed at 50 m. The duration of passive recovery was based on the work/relief ratio of 2:1 (T2:1) and 4:1 (T4:1). There was a high variability between sessions for τD' (coefficient of variation of 306%). When τD′ determined for T2:1 was applied in T4:1 and vice versa, the D'BAL model was inconsistent to predict the time to exhaustion (coefficient of variation of 29 and 28%). No linear or nonlinear relationships were found between τD′ and CS, possibly due to the high within-subject variability of τD'. These findings suggest that τD′ is not constant during two high-intensity interval sessions with the same recovery intensity. Therefore, the current D'BAL model was inconsistent to track D′ responses for swimming sessions tested herein.

Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension

ABSTRACT Objectives This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension. Methods Twenty (67 ± 7 y) older individuals with hypertension were randomly assigned to perform HIIE, MICE, or control (CON) sessions in the heated swimming pool (30–32°C). Blood pressure (BP), arterial stiffness, endothelial reactivity, and heart rate variability (HRV) were measured pre, post, and 45 min (recovery) after each intervention followed by 24-h ambulatory BP and HRV. Results One single aerobic exercise session was not effective to provoke post-exercise hypotension and vascular improvements. HIIE was superior to MICE and CON to increasing parasympathetic modulation at post and recovery. Exercise sessions showed to disturb the autonomic system at nighttime compared to CON. Conclusions These results may have important implications in water-based therapy and the elderly with hypertension

Physiological, Perceptual, and Performance Responses to the 2-Week Block of High- versus Low-Intensity Endurance Training.

This study examined the physiological, perceptual, and performance responses to a 2-wk block of increased training load and compared whether responses differ between high-intensity interval (HIIT) and low-intensity training (LIT). Thirty recreationally trained males and females performed a 2-wk block of 10 HIIT sessions (INT, n = 15) or 70% increased volume of LIT (VOL, n = 15). Running time in the 3000 m and basal serum and urine hormone concentrations were measured before (T1) and after the block (T2), and after a recovery week (T3). In addition, weekly averages of nocturnal heart rate variability (HRV) and perceived recovery were compared with the baseline. Both groups improved their running time in the 3000 m from T1 to T2 (INT = -1.8% ± 1.6%, P = 0.003; VOL = -1.4% ± 1.7%, P = 0.017) and from T1 to T3 (INT = -2.5% ± 1.6%, P < 0.001; VOL = -2.2% ± 1.9%, P = 0.001). Resting norepinephrine concentration increased in INT from T1 to T2 (P = 0.01) and remained elevated at T3 (P = 0.018). The change in HRV from the baseline was different between the groups during the first week (INT = -1.0% ± 2.0% vs VOL = 1.8% ± 3.2%, P = 0.008). Muscle soreness increased only in INT (P < 0.001), and the change was different compared with VOL across the block and recovery weeks (P < 0.05). HIIT and LIT blocks increased endurance performance in a short period. Although both protocols seemed to be tolerable for recreational athletes, a HIIT block may induce some negative responses such as increased muscle soreness and decreased parasympathetic activity.

Can Simulated Partners Boost Workout Effort in Long-Term Exercise?

Feltz, DL, Hill, CR, Samendinger, S, Myers, ND, Pivarnik, JM, Winn, B, Ede, A, and Ploutz-Snyder, L. Can simulated partners boost workout effort in long-term exercise? J Strength Cond Res 34(9): 2434-2442, 2020-We tested whether exercising with a stronger simulated (i.e., software-generated) partner leads to greater work effort compared to exercising alone, to help those seeking to maintain or improve fitness levels with long-term high-intensity training, but who find it necessary or practical to exercise in social isolation. Forty-one middle-aged adults, who participated in at least 30 minutes of vigorous exercise 3x·wk, trained on a cycle ergometer 6 days per week for 24 weeks in an alternating regimen of moderate-intensity 30-minute continuous and 3 types of high-intensity interval sessions (8 × 30-second sprints, 6 × 2-minute ladders, and 4 × 4-minute intervals). They were assigned either no partner (control), an always superior partner, or a not always superior partner. Participants varied cycle power output to increase or decrease session intensity during the repeated moderate-intensity sessions (30-minute continuous) and 1 of the 3 high-intensity sessions (4 × 4-minute intervals). Changes in intensity were used as a measure of effort motivation over time. Nested multilevel models of effort trajectory were developed and alpha was set to 0.05. For continuous and interval sessions, effort trajectory was positive and significant for those with an always superior partner, but not significantly different from control. Within interval sessions, those with an always superior partner significantly increased effort in the fourth interval compared to control (p = 0.02). Exercising with an always superior partner leads to greater work efforts during the hardest interval training compared to exercising alone.

Exercise Time and Intensity: How Much Is Too Much?

To correlate salivary hormones and time in varying heart-rate (HR) zones. The hypothesis was that chronic exercise durations >9% of total exercise time in the >90% maximum HR zone would lead to decreased variation in salivary cortisol concentration after exercise in a 2-bout high-intensity protocol compared with less or more time in this zone. A total of 35 healthy adults who regularly exercised for an average of 8hours per week recorded their HR during every training session for 3 weeks. Later, they completed an experimental day composed of two 30-minute high-intensity interval sessions separated by 4hours of nonactive recovery. The authors collected saliva samples before, immediately following, and 30minutes after each exercise session to assess changes in cortisol concentrations. There was a correlation between weekly time training at an intensity >90% maximum HR and the variables associated with overtraining. Salivary cortisol concentration fluctuated less in the participants who exercised in this extreme zone for >40minutes per week (P < .001). Based on the current study data, for individuals who regularly exercise, 4% to 9% total training time above 90% maximum HR is the ideal duration to maximize fitness and minimize symptoms related to overreaching.

High intensity interval training in patients with COPD: A bibliographic review

Introduction: Chronic obstructive pulmonary disease (COPD)is characterized by chronic limitation of airflow associatedwith a variety of pathological pulmonary changes. Pulmonaryrehabilitation programs seek to improve several aspects ofpatients with COPD. Regarding the use of physical conditioningin approaches to COPD, High Intensity Interval Training(HIIT) is defined by high intensity interval sessions with restsessions. Objective: To evaluate the effectiveness of HIIT inpatients with COPD. Materials and methods: A narrative reviewof the literature was made through the Virtual HealthLibrary databases (LILACS, MEDLINE) and PEDro, using thedescriptors High Intensity Interval Training, Chronic ObstructivePulmonary Disease and Rehabilitation, in order toobtain a synthesis on the insertion of HIIT in the pulmonaryrehabilitation of patients with COPD. Articles that addressedHIIT in individuals with COPD were included and those thatdid not correspond to the topic were excluded. Conclusion: Inspite of the need for further studies on this topic, HIIT can beused in the pulmonary rehabilitation of patients with COPDwith moderate to severe airflow limitation.Keywords: Chronic obstructive pulmonary disease; Highintensity interval training; Pulmonary rehabilitation.

Positive Effects of Augmented Feedback to Reduce Time on Ground in Well-Trained Runners.

Successful elite sprint to long-distance runners are known to have shorter ground-contact time (GCT) than their less successful counterparts. To investigate whether augmented feedback (aF) about GCT can reduce the time on ground (TOG) per minute in long-distance runners and, if so, whether this reduction improves running performance. Thirty well-trained runners were allocated to 3 groups. The intervention group (IG) received visual aF about their GCT during 8 high-intensity interval sessions in the 4-wk training period and were instructed to minimize GCT. The 1st control group (CG1) trained with the IG but was not given any feedback. The 2nd control group (CG2) followed their own training routine. Data were obtained pre- and postintervention for all 3 groups. The dependent variable was TOG per minute, computed from step frequency and GCT. The IG significantly reduced TOG (P = .043, -1.7%, 90%CL -3.1;-0.3) and improved their mean 10 × 400-m performance time (P < .001, -1.5%, 90%CL -1.9;-1.1). In contrast, the 2 control groups revealed unchanged values, indicating that normal high-intensity training and an individualized routine without aF were not able to reduce TOG. The fact that CG1 received the same instructions and participated in the same training sessions as the IG underlined that aF was crucial to reduce TOG. The provision of aF about GCT seems to be a promising approach that should be considered during training practice of well-trained runners.

Effect of exercise intensity on Nrf2 signalling in young men

Introduction: The transcription factor Nrf2 is the master regulator of antioxidant defence. Recent data indicate a single bout of moderate-intensity stationary cycling at a constant workload upregulates Nrf2 signalling in young, but not older men; however, the role of exercise intensity on Nrf2 activation has not been tested. We hypothesised that a high-intensity interval session would elicit a greater Nrf2 response than moderate aerobic exercise.Methods: Nrf2 signalling in response to two 30-min cycling protocols (high-intensity interval and constant workload) was compared in young men (25 ± 1y, n = 16). Participants completed exercise trials in random order with blood collected pre-, immediately post-, and 30-mins post exercise. Five participants completed a control trial without any physical activity. Nrf2 signalling was determined by measuring protein expression of Nrf2 in whole cell and nuclear fractions. Plasma 8-isoprostanes as well as peripheral mononuclear cell glutathione reductase (GR) and superoxide dismutase activity were measured as markers of oxidative stress.Results: The exercise trials elicited significant increases in nuclear Nrf2 (p < .01), but increases in whole cell Nrf2 did not reach statistical significance. GR activity and plasma 8-isoprostanes increased significantly in response to exercise (p < .05), and GR response was higher in the high-intensity trial (p < .05).Conclusion: Our findings indicate that acute aerobic exercise elicits activation of nuclear Nrf2, regardless of exercise intensity, but that higher-intensity exercise results in greater activity of GR. Future experiments should explore the effect of exercise mode and duration on Nrf2 signalling, and the role of intensity in compromised populations.

Simulated Partners and Collaborative Exercise (SPACE) to boost motivation for astronauts: study protocol.

BackgroundAstronauts may have difficulty adhering to exercise regimens at vigorous intensity levels during long space missions. Vigorous exercise is important for aerobic and musculoskeletal health during space missions and afterwards. A key impediment to maintaining vigorous exercise is motivation. Finding ways to motivate astronauts to exercise at levels necessary to mitigate reductions in musculoskeletal health and aerobic capacity have not been explored. The focus of Simulated Partners and Collaborative Exercise (SPACE) is to use recently documented motivation gains in task groups to heighten the exercise experience for participants, similar in age and fitness to astronauts, for vigorous exercise over a 6-month exercise regimen. A secondary focus is to determine the most effective features in simulated exercise partners for enhancing enjoyment, self-efficacy, and social connectedness. The aims of the project are to (1) Create software-generated (SG) exercise partners and interface software with a cycle ergometer; (2) Pilot test design features of SG partners within a video exercise game (exergame), and (3) Test whether exercising with an SG partner over 24-week time period, compared to exercising alone, leads to greater work effort, aerobic capacity, muscle strength, exercise adherence, and enhanced psychological parameters.Methods/DesignThis study was approved by the Institutional Review Board (IRB). Chronic exercisers, between the ages 30 and 62, were asked to exercise on a cycle ergometer 6 days per week for 24 weeks using a routine consisting of alternating between moderate-intensity continuous and high-intensity interval sessions. Participants were assigned to one of three conditions: no partner (control), always faster SG partner, or SG partner who was not always faster. Participants were told they could vary cycle ergometer output to increase or decrease intensity during the sessions. Mean change in cycle ergometer power (watts) from the initial continuous and 4 min. interval sessions was the primary dependent variable reflecting work effort. Measures of physiological, strength, and psychological parameters were also taken.DiscussionThis paper describes the rationale, development, and methods of the SPACE exergame. We believe this will be a viable intervention that can be disseminated for astronaut use and adapted for use by other populations.

Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training

Reactive oxygen and nitrogen species are important signal molecules for adaptations to training. Due to the antioxidant properties of vitamin C and E, supplementation has been shown to blunt adaptations to endurance training. In this study, we investigated the effects of vitamin C and E supplementation and endurance training on adaptations in endogenous antioxidants and heat shock proteins (HSP). Thirty seven males and females were randomly assigned to receive Vitamin C and E (C + E; C: 1000 mg, E: 235 mg daily) or placebo (PLA), and underwent endurance training for 11 weeks. After 5 weeks, a subgroup conducted a high intensity interval session to investigate acute stress responses. Muscle and blood samples were obtained to investigate changes in proteins and mRNA related to the antioxidant and HSP system. The acute response to the interval session revealed no effects of C + E supplementation on NFκB activation. However, higher stress responses to exercise in C + E group was indicated by larger translocation of HSPs and a more pronounced gene expression compared to PLA. Eleven weeks of endurance training decreased muscle GPx1, HSP27 and αB‐crystallin, while mnSOD, HSP70 and GSH remained unchanged, with no influence of supplementation. Plasma GSH increased in both groups, while uric acid decreased in the C + E group only. Our results showed that C + E did not affect long‐term training adaptations in the antioxidant‐ and HSP systems. However, the greater stress responses to exercise in the C + E group might indicate that long‐term adaptations occurs through different mechanisms in the two groups.

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double‐blind, randomised, controlled trial

In this double-blind, randomised, controlled trial, we investigated the effects of vitamin C and E supplementation on endurance training adaptations in humans. Fifty-four young men and women were randomly allocated to receive either 1000 mg of vitamin C and 235 mg of vitamin E or a placebo daily for 11 weeks. During supplementation, the participants completed an endurance training programme consisting of three to four sessions per week (primarily of running), divided into high-intensity interval sessions [4-6 × 4-6 min; >90% of maximal heart rate (HRmax)] and steady state continuous sessions (30-60 min; 70-90% of HRmax). Maximal oxygen uptake (VO2 max ), submaximal running and a 20 m shuttle run test were assessed and blood samples and muscle biopsies were collected, before and after the intervention. Participants in the vitamin C and E group increased their VO2 max (mean ± s.d.: 8 ± 5%) and performance in the 20 m shuttle test (10 ± 11%) to the same degree as those in the placebo group (mean ± s.d.: 8 ± 5% and 14 ± 17%, respectively). However, the mitochondrial marker cytochrome c oxidase subunit IV (COX4) and cytosolic peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1α) increased in the m. vastus lateralis in the placebo group by 59 ± 97% and 19 ± 51%, respectively, but not in the vitamin C and E group (COX4: -13 ± 54%; PGC-1α: -13 ± 29%; P ≤ 0.03, between groups). Furthermore, mRNA levels of CDC42 and mitogen-activated protein kinase 1 (MAPK1) in the trained muscle were lower in the vitamin C and E group than in the placebo group (P ≤ 0.05). Daily vitamin C and E supplementation attenuated increases in markers of mitochondrial biogenesis following endurance training. However, no clear interactions were detected for improvements in VO2 max and running performance. Consequently, vitamin C and E supplementation hampered cellular adaptations in the exercised muscles, and although this did not translate to the performance tests applied in this study, we advocate caution when considering antioxidant supplementation combined with endurance exercise.

Short intervals induce superior training adaptations compared with long intervals in cyclists – An effort‐matched approach

The purpose of this study was to compare the effects of 10 weeks of effort-matched short intervals (SI; n = 9) or long intervals (LI; n = 7) in cyclists. The high-intensity interval sessions (HIT) were performed twice a week interspersed with low-intensity training. There were no differences between groups at pretest. There were no differences between groups in total volume of both HIT and low-intensity training. The SI group achieved a larger relative improvement in VO(2max) than the LI group (8.7% ± 5.0% vs 2.6% ± 5.2%), respectively, P ≤ 0.05). Mean effect size (ES) of the relative improvement in all measured parameters, including performance measured as mean power output during 30-s all-out, 5-min all-out, and 40-min all-out tests revealed a moderate-to-large effect of SI training vs LI training (ES range was 0.86-1.54). These results suggest that the present SI protocol induces superior training adaptations on both the high-power region and lower power region of cyclists' power profile compared with the present LI protocol.

Low- and High-Volume of Intensive Endurance Training Significantly Improves Maximal Oxygen Uptake after 10-Weeks of Training in Healthy Men

Regular exercise training improves maximal oxygen uptake (VO2max), but the optimal intensity and volume necessary to obtain maximal benefit remains to be defined. A growing body of evidence suggests that exercise training with low-volume but high-intensity may be a time-efficient means to achieve health benefits. In the present study, we measured changes in VO2max and traditional cardiovascular risk factors after a 10 wk. training protocol that involved three weekly high-intensity interval sessions. One group followed a protocol which consisted of 4×4 min at 90% of maximal heart rate (HRmax) interspersed with 3 min active recovery at 70% HRmax (4-AIT), the other group performed a single bout protocol that consisted of 1×4 min at 90% HRmax (1-AIT). Twenty-six inactive but otherwise healthy overweight men (BMI: 25–30, age: 35–45 y) were randomized to either 1-AIT (n = 11) or 4-AIT (n = 13). After training, VO2max increased by 10% (∼5.0 mL⋅kg−1⋅min−1) and 13% (∼6.5 mL⋅kg−1⋅min−1) after 1-AIT and 4-AIT, respectively (group difference, p = 0.08). Oxygen cost during running at a sub-maximal workload was reduced by 14% and 13% after 1-AIT and 4-AIT, respectively. Systolic blood pressure decreased by 7.1 and 2.6 mmHg after 1-AIT and 4-AIT respectively, while diastolic pressure decreased by 7.7 and 6.1 mmHg (group difference, p = 0.84). Both groups had a similar ∼5% decrease in fasting glucose. Body fat, total cholesterol, LDL-cholesterol, and ox-LDL cholesterol only were significantly reduced after 4-AIT. Our data suggest that a single bout of AIT performed three times per week may be a time-efficient strategy to improve VO2max and reduce blood pressure and fasting glucose in previously inactive but otherwise healthy middle-aged individuals. The 1-AIT type of exercise training may be readily implemented as part of activities of daily living and could easily be translated into programs designed to improve public health.Trial Registration ClinicalTrials.gov NCT00839579

Passive Recovery Is Superior to Active Recovery During a High-Intensity Shock Microcycle

The purpose was to examine the effects of a 2-week high-intensity shock microcycle on maximal oxygen consumption and parameters of exercise performance in junior triathletes on the one hand and to evaluate the long-term effects of active (A) vs. passive (P) recovery on the other hand. Sixteen healthy junior triathletes participated in the study. For the assignment to the A or P group, the subjects were matched according to age and performance. Within 2 weeks, a total of 15 high-intensity interval sessions within three 3-day training blocks were performed. Before and 1 week after the last training session, the athletes performed a ramp test to determine V[Combining Dot Above]O2max, a time trial (TT) and a Wingate test. Furthermore, total hemoglobin (Hb) mass was determined. The results of the whole group, independent of the arrangement of recovery, were analyzed at first; second, the A and P groups were analyzed separately. Peak power output (PPO) during the ramp test and TT performance significantly increased in the whole group. The comparison of the 2 groups revealed increases for the mentioned parameters and for V[Combining Dot Above]O2 and power output at VT2 for the P group only. The V[Combining Dot Above]O2max did not change. Wingate performance increased in the A group only. The tHb mass slightly decreased. The main finding of this study was that a 14-day shock microcycle is able to improve TT performance and PPO in junior triathletes in a short period of time. Furthermore, not only the intensity but also the arrangement of interval training seems to be important as well, because only the P group showed improvements in endurance performance, despite a slightly lower training volume. These findings might be relevant for future arrangements of high-intensity interval training.

Energy Expenditure And Fat Utilization During And After Interval Versus Continuous Self-paced Exercise Bouts

PURPOSE: Exercise is often performed to achieve high energy expenditure (EE) and fat oxidation (FO). The purpose of the study was to compare exercise EE, early recovery EE (REE), and total FO during self-paced "hard interval" vs "talking intensity" continuous exercise bouts typical of fitness industry exercise prescriptions. METHODS: After preliminary testing, 9 regularly active males (age 28 ± 6 yr, VO2max 55 ± 5 ml·min-1·kg-1) performed a self-paced high intensity interval session (INT) consisting of six, 4 min work bouts interspersed by 2 min recovery periods (34 min total exercise time) with continuous gas exchange measurement during the 34 min exercise session and for 30 min post exercise. Responses were compared with those measured during a "talking intensity" exercise bout of identical total duration (SS). The two bouts were performed in randomized order. EE, REE, and FO were estimated from continuous measurements of respiratory gas exchange. Fat oxidation calculations are considered minimum estimates due to presumed contamination of CO2 production with CO2 release due to H+buffering. RESULTS: The INT session elicited higher average heart rate (171 ± 14 vs 154 ± 15, p<0.001), blood lactate concentration (6.5 ± 2.8 vs 2.1 ± 1.1 mmol·L-1, p<0.001), and RPE (17 ± 1 vs 12 ± 1, p<0.001) than the SS session. EE during INT was ∼12% higher (555 ± 75 vs 495 ± 68 kcal, p<0.01) and 30min REE was 23% higher (89 ± 15 vs 72 ± 9 kcal, p<0.01). FO during 34 min exercise tended to be higher in SS (13.0 ± 5.3 vs 9.4 ± 4.5 g, p = 0.12). FO during the first 30 min post-exercise was higher after INT (4.5± 1.4 vs 2.5 ± 1.3 g. p = 0.02). Total FO (34 min exercise+30 min recovery) was similar in the interval based and continuous exercise sessions (13.0 ± 3.7 vs 15.5 ± 6.4 g, p= 0.56). CONCLUSIONS: In this study, we have attempted to simulate two exercise prescriptions typical of the time constraints and intensity goals of "1 hour fitness classes". Our results suggest that for the same time investment, self-paced interval training results in significantly greater total energy expenditure and similar total fat oxidation than continuous exercise performed at "talking intensity."

The effect of consecutive days of exercise on markers of oxidative stress

We examined the influence of 3 consecutive days of high-intensity cycling on blood and urinary markers of oxidative stress. Eight highly-trained male cyclists (VO2 max 76 +/- 4 mL.kg-1.min-1; mean +/- SD) completed an interval session (9 exercise bouts lasting 30 s each, at 150% peak power output) on day 1, followed by 2 laboratory-simulated 30 km time trials on days 2 and 3. The cyclists also completed a submaximal exercise trial matched to the interval session for oxygen consumption. Blood was collected pre- and post-exercise for the determination of malondialdehyde (MDA), total antioxidant status (TAS), vitamin E, and the antioxidant enzyme activity of superoxide dismutase and glutathione peroxidase, while urine was collected for the determination of allantoin. There were significant increases in plasma MDA concentrations (p < 0.01), plasma TAS (p < 0.01), and urinary allantoin excretion (p < 0.01) following the high-intensity interval session on day 1, whereas plasma vitamin E concentration significantly decreased (p = 0.028). Post-exercise changes in plasma MDA (p = 0.036), TAS concentrations (p = 0.039), and urinary allantoin excretion (p = 0.031) were all significantly attenuated over the 3 consecutive days of exercise, whereas resting plasma TAS concentration was elevated. There were no significant changes in plasma MDA, TAS, or allantoin excretion following submaximal exercise and there were no significant changes in antioxidant enzyme activity over consecutive days of exercise or following submaximal exercise. Consecutive days of high-intensity exercise enhanced resting plasma TAS concentration and reduced the post-exercise increase in plasma MDA concentrations.