Higher Food Intake Research Articles

Crosstalk between imbalanced gut microbiota caused by antibiotic exposure and rotavirus replication in the intestine

ObjectiveRotavirus (RV), one of non-enveloped double-strained RNA viruses, can cause infantile diarrheal illness. It is widely accepted that RV is transmitted mainly via feces-oral route. However, infected asymptomatic adults are becoming the source of infection. It is necessary to explore the underlying mechanism of RV replication in adult's intestine. MethodsAfter recruiting healthy volunteers and RV asymptomatic carriers, we firstly investigated the association of animal-derived food intake with antibiotic level in urine samples. Secondly, we compared the difference in the structure of gut microbiota, and identified the taxa that most likely explained the difference. Finally, we investigated the impact of lipopolysaccharide (LPS), produced by gram-negative bacteria, on RV replication in vivo and in vitro. ResultsWe found that 10% of participants were RV asymptomatic carriers in our study. High intake of animal-derived food was positively correlated to antibiotic level in urine samples. The disrupted gut microbiota in RV carriers was characterized by high abundance of antibiotic resistant gram-negative bacteria and high level of LPS. The disrupted gut microbiota caused by penicillin treatment was benefit to RV replication in vivo. LPS enhanced RV thermal stability in vitro. ConclusionsOur findings suggest that the imbalanced gut microbiota caused by antibiotic exposure plays an important role in RV replication, and brings risk to health complications.

Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes

Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment.In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR. Food intake was evaluated using a food frequency questionnaire based on food groups. The oral environment was assessed using xerostomia and periodontal comprehensive examination.In total, 45.3%, 28.0%, and 18.7% of subjects showed lower umami taste sensitivity, low sweet taste sensitivity, and low salt taste sensitivity, respectively. Lower umami sensitivity correlated with lower estimated glomerular filtration rate and higher energy-source food intake. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression than those with lower plaque control record.Reduced umami taste sensitivity is associated with decreased renal function and high energy food intake in diabetes. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression, suggesting that the oral environment affects taste gene expression. J. Med. Invest. 70 : 241-250, February, 2023.

Chronic Low or High Nutrient Intake and Myokine Levels.

Inadequate nutrient availability has been demonstrated to be one of the main factors related to endocrine and metabolic dysfunction. We investigated the role of inadequate nutrient intakes in the myokine levels of runners. Sixty-one amateur runners participated in this study. The myokine levels were determined using the Human Magnetic Bead Panel from plasma samples collected before and after the marathon. Dietary intake was determined using a prospective method of three food records. The runners with lower carbohydrate and calcium intakes had higher percentages of fat mass (p < 0.01). The runners with a sucrose intake comprising above 10% of their energy intake and an adequate sodium intake had higher levels of BDNF (p = 0.027 and p = 0.031). After the race and in the recovery period, the runners with adequate carbohydrate intakes (g/kg) (>5 g/kg/day) had higher levels of myostatin and musclin (p < 0.05). The runners with less than 45% of carbohydrate of EI had lower levels of IL-15 (p = 0.015) and BNDF (p = 0.013). The runners with higher cholesterol intakes had lower levels of irisin (p = 0.011) and apelin (p = 0.020), and those with a low fiber intake had lower levels of irisin (p = 0.005) and BDNF (p = 0.049). The inadequate intake influenced myokine levels, which promoted cardiometabolic tissue repair and adaptations to exercise.

Managing prolific sows in tropical environments.

Litter size in modern sows has been dramatically improved in recent decades by genetic selection for highly prolific sows. In a tropical environment, the average total number of pigs born and number born alive are reported to be as high as 17.2 and 15.1 piglets per litter, respectively. Therefore, the new production target in many herds aims to achieve 30-40 pigs weaned per sow per year. Despite the improvements in litter size, the mean preweaning piglet mortality rate remains high, at between 10% and 20%, in major pig-producing countries. A sufficient daily feed intake by lactating sows is important for high milk production as sow milk yield is the limiting factor for piglet growth rate. Heat stress, which can occur when the ambient temperatures rise above 25°C, is one of the major problems that decreases daily feed intake and compromises milk yield. Therefore, it is necessary to encourage high feed intakes to achieve high milk yields. However, even with high nutrient intakes, productivity can be constrained by intestinal barrier function, limiting digestive ability,and allowing potential pathogens and/or toxins to become systemic. This is more likely greater under tropical conditions because of heat stress, exacerbating sow fertility problems. Underpinning sow herd performance, including responses to environmental challenges, is the selection of appropriate gilts, for example,selection and management for early puberty, thus presumably selecting the more fertile gilts and the correct management of lactation to improve the number of weaned piglets are some of the key factors for future reproductive efficiency of the farm under tropical conditions.

Effect of acute and chronic administration of hot water extract of P. Americana on some metabolic parameters in diabetic rats

The challenge of comorbid diseases and especially their management. Posing greater challenge are phytomedical approach without proper scientific testing and more also paucity of modern equipment for research and funding. The need to authenticate medicinal herbs used in the management of Diabetes Mellitus (DM) as one of the common metabolic diseases becomes imperative. This study aimed at evaluating the effect of acute and chronic administration of hot water extract of P. americana on some metabolic parameters in diabetic rats. Thirty young adult healthy male albino rats (wistar strain) weighing between 205-251 g were made diabetic by administration of 80 mg/kg streptozotocin (STZ). The animals were divided into two equal groups of 15 rats each, singly placed in metabolic cages for the acute and chronic treatments studies. The rats were further divided into three groups of 5 animals each and treated with different concentrations of stem-bark hot water extract of Persea americana (HWE-PA) and distilled water while the body weight, food intake, faecal output, water intake and urine output were measured and recorded daily for a period of 5 days for the acute and 28 days for the chronic treatments. Results showed a higher percentage change in body weights, higher food intake and faecal output and lower values in water intake and urine output in both acute and chronic administration of HWE-PA to STZ-induced hyperglycaemic rats compared to the control groups. Both acute and chronic administration of Hot water extract of the stem-bark animals extracts of Persea americana (HWE-PA) presented antidiabetic activity STZ-induced hyperglycaemic rats as evident its ameliorating effect on the body weight, food intake, faecal output, water intake and urine output in STZ-induced hyperglycaemic rats, thus supports its phytomedicine use as an antidiabetic agent.

Swedish recreational athletes as subjects for sustainable food consumption: focus on performance and sustainability

A high food intake can contribute to increased greenhouse-gas emissions, and therefore consumers with a high energy intake are important to include when exploring sustainable foodways. In this paper, semi-structured interviews and a seven-day food record were used to understand the climate impact of food, analyse mundane food practices, and identify sustainable routines among high-energy consumers represented by a group of recreational athletes. Social practice theory and the interdependent relationship between competence, material, and meaning unfold an Athletic performance-related food practice with a focus on performance, time-saving strategies, structured eating, and a possible Climate-conscious athletic performance-related food practice where the food practice also includes important sustainability aspects. The results indicate a high carbon footprint from high energy and dairy and whey protein intake. Some recreational athletes demonstrate an awareness of the climate impact of food, but they need to be convinced that more sustainable ways are possible without jeopardising athletic performance.

Diet and Disease Activity in Patients with Axial Spondyloarthritis: SpondyloArthritis and NUTrition Study (SANUT).

Axial Spondyloarthritis (axSpA) patients with inflamed intestines have higher SpA activity. Diets that modulate microbiota may influence inflammation and SpA activity. Today, data concerning the impact of diet on SpA activity are scarce. SANUT was a single-center, noninterventional, cohort study that assessed dietetic profiles associated with SpA activity in axSpA. Demographic, clinical, SpA-related, quality of life (QoL), fatigue, physical activity, and dietary data were collected. SpA activity was assessed by Ankylosing Spondylitis Disease Activity Score (ASDAS) and by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). We assessed whether high SpA activity was associated with nutriment consumption. Between 12 February 2018 and 12 February 2020, 278 patients participated. High SpA activity, as measured by ASDAS and BASDAI, was significantly associated with higher body mass index and waist circumference, negative HLA-B27, lower QoL, higher fatigue, and higher digestive-symptom scores. Furthermore, high SpA activity, as measured by BASDAI, was associated with female sex, smoking status, patients who were not actively employed, reduced physical activity, and high intake of ultra-transformed foods, while high SpA activity, as measured by ASDAS, was associated with low intake of omega-3 PUFAs and fiber. Therefore, low intakes of omega-3 PUFAs and fiber, and high intake of ultra-transformed foods, are associated with high SpA activity.

Ultra-processed foods as a possible culprit for the rising prevalence of inflammatory bowel diseases

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, and the exact pathogenesis is still unclear. It is believed that IBD develops in response to a complex interaction between the microbiota, environmental factors, and the immune system, in genetically predisposed individuals. Identifying these environmental factors will offer more insight in the development of the disease, and reveal new therapeutic targets for IBD patients. One of the environmental factors that has gained more interest over the last years is our diet. The prevalence of IBD has increased significantly and this increase is thought to be associated with a 'Western diet', characterized by high intake of fats, added sugar, meat, and ultra-processed foods (UPFs). The UPFs now account for almost 50% of the energy intake in Westernized countries and are therefore an important characteristic of this Western diet. UPFs are characterized by higher amounts of salt, fat, sugar and the presence of different food additives. Epidemiological studies have found associations between UPF intake and a range of non-communicable diseases, including inflammatory bowel disease (IBD). Preclinical and clinical evidence suggest that non-nutritive ingredients and additives, present in UPFs, can negatively affect different components of the intestinal barrier, such as the microbiota, the mucus layer, the epithelium, and the immune cells in the lamina propria. Disruption of this barrier can cause the immune system to encounter an increased bacterial exposure, leading to an aberrant immune response. In this article, the available evidence on the possible role of UPFs and their components in the increasing incidence and prevalence of IBD is reviewed. These findings can be translated to the clinic and may be helpful to consider when giving dietary advice to IBD patients. A better understanding of the role of UPFs may lead to less restrictive diets for patients with IBD, hence increasing the dietary compliance and efficacy of exclusion diets.

Egg white hydrolysate from simulated gastrointestinal digestion alleviates the inflammation and improves the nutritional status in TNBS-induced Crohn’s disease rats

• EWH reduced the body weight loss and increased food intake of CD rats. • EWH ameliorated the disease activity and colon damage of CD rats. • EWH reduced the level of inflammation in the colon of CD rats. • EWH increased the expression of tight junction proteins of the colon of CD rats. • EWH improved the nutritional status in the plasma of CD rats. This paper aimed to investigate the amelioration of egg white hydrolysate (EWH) in Crohn’s disease. Male Sprague-Dawley rats were rectally administrated tri­nitrobenzene sulfonic acid (TNBS) (100 mg/kg) at day 0 to induce CD and then intragastrically administrated saline (model group, n = 8) or EWH (1 g/kg) (EWH group, n = 8) for four weeks. Results showed that the EWH group had higher food intake, lower body weight loss, and colonic histopathological damage compared with the model group ( P < 0.05). In addition, the pro-inflammatory interleukin (IL)-1β, IL-6, IL-12, IL-17A, IL-23, and tumor necrosis factor-α were decreased but the anti-inflammatory IL-10 was increased in the EWH group ( P < 0.05). Moreover, EWH improved the expressions of tight junction proteins in the colon and the levels of total protein, albumin, prealbumin, hemoglobin, transferrin, and lymphocyte count in the serum ( P < 0.05). It implies the potential of EWH as an ingredient of functional foods in the prevention and management of CD.

New frontiers in risk assessments related to diets, health and the environment

Abstract Based on the sustainable development goals agenda, public health experts should approach the study of planetary diets, environment, and health with a holistic approach that includes both human and planetary health. Modelling studies help in estimating priorities while attaining differences across countries. Future scenarios vary according to priorities to be set. When aiming only at fulfilling food-security objectives, studies suggest that reductions in premature mortality have few environmental co-benefits. In contrast, modelling studies that include environmental goals indicate the potential for reducing environmental impacts while improving diet quality and overall health outcomes, especially in high-income countries. The scenarios indicate that focusing on dietary changes towards healthy and balanced dietary pattern seems an ideal strategy to improve both mortality risk and the environmental impact, although the magnitude of the effects may vary across countries. Weight and dietary risk factors have traditionally been considered separate categories. A new approach can be proposed for attributing weight-related risks to food intake at global, regional, and national levels. When comparing current consumption patterns to diets that for each country minimise diet and weight-related risks, a total of 5 million weight-related deaths in 2019 were attributed to the overconsumption of refined grains, dairy, red and processed meat, sugar, and eggs, and to the underconsumption of oils, and legumes, among others. A large share of deaths attributable to high intake of animal source foods and imbalanced grain intake occurred in countries with the higher high human development index, while more than a third due to imbalanced sugar and oil intake occurred in medium ones. Attributing weight-related risks to food intake can inform food-based interventions for reducing the burden of preventable deaths associated with imbalanced weight levels.

Assessment of the Erosive Potential of Mineral Waters in Bovine Dental Enamel

Background: High intake of acidic foods and beverages has been often associated with the onset of dental erosive wear. Objetive: This study in vitro assessed the pH of different mineral waters marketed in Brazil and their effects on the properties and surface of dental enamel. Methods: Forty-eight bovine incisor specimens were divided into four groups (n=12): CG-control group, PeG-Perrier, PrG-Prata, and SLG-São Lourenço. The immersion cycles were performed after analysis of the pH of the waters, for 5 days (5 minutes in mineral water and 60 minutes in artificial saliva). Knoop micro-hardness was assessed by means of three indentations with a load of 50kgf for 15 seconds, and surface roughness with a cut off of 0.25mm. The data were analysed using Student's t -test, ANOVA, and Tukey test, with a significance level of 5%. Results: The groups of waters with lower pH (Perrier ® and São Lourenço ® ) exhibited a reduction in Knoop micro-hardness ( p &lt;0.0001) and an increase in surface roughness ( p =0.04 and p =0.004, respectively). The Prata water group did not exhibit significant changes in Knoop micro-hardness ( p =0.07) and surface roughness ( p =0.26). Conclusion: Mineral waters with a pH below the critical value can lead to a reduction in surface hardness and roughness in the bovine enamel.

Gastric bypass surgery weight loss-independently induces gut Il-22 release in association with improved glycemic control in obese Zucker fatty rats

BackgroundRoux-en-Y gastric bypass surgery (RYGB) improves glycemic control in individuals with severe obesity beyond the effects of weight loss alone. To identify potential underlying mechanisms, we asked how equivalent weight loss from RYGB and from chronic caloric restriction impact gut release of the metabolically beneficial cytokine interleukin-22 (Il-22). MethodsObese male Zucker fatty rats were randomized into sham-operated (Sham), RYGB, and sham-operated, body weight-matched to RYGB (BWM) groups. Food intake and body weight were measured regularly for 4 weeks. An oral glucose tolerance test (OGTT) was performed on postoperative day 27. Portal vein plasma, systemic plasma, and whole-wall samples from throughout the gut were collected on postoperative day 28. Gut Il-22 mRNA expression was determined by real-time quantitative PCR. Plasma Il-22 levels were determined by enzyme-linked immunosorbant assay (ELISA). ResultsRYGB and BWM rats had lower food intake and body weight as well as superior blood glucose clearing capability compared with Sham rats. RYGB rats also had superior blood glucose clearing capability compared with BWM rats despite having similar body weights and higher food intake. Il-22 mRNA expression was approximately 100-fold higher specifically in the upper jejunum in RYGB rats compared with Sham rats. Il-22 protein was only detectable in portal vein (34.1 ± 9.4 pg/mL) and systemic (46.9 ± 10.5 pg/mL) plasma in RYGB rats. Area under the curve of blood glucose during the OGTT, but not food intake or body weight, negatively correlated with portal vein and systemic plasma Il-22 levels in RYGB rats. ConclusionsThese results suggest that induction of gut Il-22 release might partly account for the weight loss-independent improvements in glycemic control after RYGB, and further support the use of this cytokine for the treatment of metabolic disease.

A Comparison of the Australian Dietary Guidelines to the NOVA Classification System in Classifying Foods to Predict Energy Intakes and Body Mass Index.

NOVA classification distinguishes foods by level of processing, with evidence suggesting that a high intake of ultra-processed foods (UPFs, NOVA category 4) leads to obesity. The Australian Dietary Guidelines, in contrast, discourage excess consumption of “discretionary foods” (DFs), defined according to their composition. Here, we (i) compare the classification of Australian foods under the two systems, (ii) evaluate their performance in predicting energy intakes and body mass index (BMI) in free-living Australians, and (iii) relate these outcomes to the protein leverage hypothesis of obesity. Secondary analysis of the Australian National Nutrition and Physical Activity Survey was conducted. Non-protein energy intake increased by 2.1 MJ (p < 0.001) between lowest and highest tertiles of DF intake, which was significantly higher than UPF (0.6 MJ, p < 0.001). This demonstrates that, for Australia, the DF classification better distinguishes foods associated with high energy intakes than does the NOVA system. BMI was positively associated with both DFs (−1. 0, p = 0.0001) and UPFs (−1.1, p = 0.0001) consumption, with no difference in strength of association. For both classifications, macronutrient and energy intakes conformed closely to the predictions of protein leverage. We account for the similarities and differences in performance of the two systems in an analysis of Australian foods.

Antioxidants in oral medicine: A review

The lifestyle deviations in recent past years and stress-related work regularly instigate lots of complications, like emotional and mental trauma to our body. Abusive habits like pan, gutka, supari, cigarettes add insult to it. Consequences in the release of free radicles triggering oxidative damage to cells. Leading to various diseases and disorders. Antioxidants are regularly found in many food products like leafy vegetables and fruits. Antioxidants are capable of stabilizing or deactivating, free radicals beforehand they attack cells. Antioxidants are critical for preserving optimal cellular and systemic health and well-being. High intakes of antioxidant nutrients from food sources appear to offer some health advantages. It is valuable to eat a wide variety of cereals, fruits, and vegetables rather than taking only these supplements.

Dietary Phytochemical Index and the Risk of Breast Cancer: A Case-Control Study

High intakes of phytochemical-rich foods might have beneficial effects on reducing breast cancer risk. In this study, we assessed the association between the dietary phytochemical index (PI) and breast cancer risk in a sample of premenopausal Turkish women. This case-control study was conducted on 70 newly diagnosed breast cancer cases and matched 70 healthy controls. Dietary intake was assessed using a validated food frequency questionnaire and dietary phytochemical indexes were calculated with two different methods. The mean PI score of participants was 19.9 ± 9.52 and 23.0 ± 8.95 in cases and controls, respectively (p = 0.046). After adjusting for energy intake, the risk of breast cancer significantly increased by 29.5% in the third quartile as compared to the fourth quartile of dietary PI (OR = 0.295, 95%CI = 0.106–0.822). Higher dietary PI was negatively associated with breast cancer risk; therefore, dietary PI may be suggested as an important contributor to dietary intake for breast cancer.

Association of major dietary patterns and different obesity phenotypes in Southwest China: the China Multi-Ethnic Cohort (CMEC) Study.

Dietary behavior is an important part of lifestyle interventions for obesity and its cardiovascular comorbidities. However, little is known about associations between dietary patterns and obesity phenotypes in Southwest China, a region with unique dietary patterns and significant heterogeneity in obesity. Data from the baseline survey of the China Multi-Ethnic Cohort in Southwest China were analyzed (n = 64,448). Dietary intakes during the past year were measured with the semi-quantitative Food Frequency Questionnaire (s-FFQ). Principal component factor analysis (PCFA) was used to identify dietary patterns. Multinomial logistic regressions were used to examine the associations between dietary patterns and obesity phenotypes and stratified analyses were performed to assess whether the associations differed across demographic variables. Three dietary patterns were identified and then named according to their apparent regional gathering characteristics: the Sichuan Basin dietary pattern (characterized by high intakes of various foods), the Yunnan-Guizhou Plateau dietary pattern (characterized by agricultural lifestyles), and the Qinghai-Tibet Plateau dietary pattern (characterized by animal husbandry lifestyles), respectively. Higher adherence to the Sichuan Basin dietary pattern was positively associated with metabolically healthy overweight/obesity (MHO, OR 1.13, 95% CI 1.05-1.21) but negatively associated with metabolically unhealthy normal weight (MUNW, OR 0.78, 95% CI 0.65-0.95). Higher adherence to the other two dietary patterns was positively associated with MHO and metabolically unhealthy overweight/obesity (MUO). Besides, differences in socioeconomic status also affected the relationship between dietary patterns and obesity phenotypes. Adherence to the more diverse Sichuan basin dietary pattern performed a mixed picture, while the other two may increase the risk of obesity phenotypes, which indicates nutritional interventions are urgently needed.

Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation.

Telomere shortening is the main molecular mechanism of aging, but not the only one. The adaptive immune system also ages, and older organisms tend to develop a chronic pro-inflammatory status with low-grade inflammation characterized by chronic activation of the innate immune system, called inflammaging. One of the main stimuli that fuels inflammaging is a high nutrient intake, triggering a metabolic inflammation process called metainflammation. In this study, we report the anti-inflammatory activity of several senolytic drugs in the context of chronic inflammation, by using two different zebrafish models: (i) a chronic skin inflammation model with a hypomorphic mutation in spint1a, the gene encoding the serine protease inhibitor, kunitz-type, 1a (also known as hai1a) and (ii) a non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) model with inflammation induced by a high-fat diet. Our results show that, although these models do not manifest premature aging, the senolytic drugs dasatinib, navitoclax, and venetoclax have an anti-inflammatory effect that results in the amelioration of chronic inflammation.

Ultra-processed Foods and Cardiometabolic Health Outcomes: from Evidence to Practice.

Poor diet quality is the leading risk factor related to the overall cardiometabolic disease burden in the USA and globally. We review the current evidence linking ultra-processed foods and cardiometabolic health risk and provide recommendations for action at the clinical and public health levels. A growing body of evidence conducted in a variety of study populations supports an association between ultra-processed food intake and increased risk of metabolic syndrome, hypertension, type 2 diabetes, overweight and obesity trajectories, and cardiovascular disease. The strongest evidence is observed in relation to weight gain and obesity among adults, as this association is supported by high-quality epidemiological and experimental evidence. Accumulating epidemiologic evidence and putative biological mechanisms link ultra-processed foods to cardiometabolic health outcomes. The high intake of ultra-processed foods in all population groups and its associated risks make ultra-processed foods an ideal target for intensive health promotion messaging and interventions.

Dietary Patterns and Nutrient Intake in University Students of Macao: A Cross-Sectional Study.

Background: Nutritional status affects the health of the public and is one of the key factors influencing social-economic development. To date, little research on the nutritional status of the Macao university student population has been conducted. Objectives: To identify and evaluate the dietary pattern and the nutritional intake among Macao university students. Methods: The Macao students were selected by the stratified cluster random sampling method. A semi-quantitative food frequency questionnaire was used to investigate food consumption. Data were analyzed through a t-test and factor analysis by using SPSS Version 24.0. Results: A total of 1230 questionnaires were distributed. From the respondents, 1067 (86.7%) were valid. In general, we identified three major dietary patterns in this population: (1) fruit and vegetable dietary pattern, characterized by abundant consumption of fruits and vegetables; (2) grain and high fat dietary pattern, characterized as high intakes of grains and animal foods; (3) high sugar dietary pattern, characterized by a large quantity of daily sugary drinks. The average daily intake of vitamin A, thiamine, calcium, and iodine were significantly lower than the Chinese Recommended Nutrient Intake (RNI) in the subjects. Conclusions: The dietary pattern of Macao students is similar to that of other Asians. Surprisingly, the daily intake of vitamin A, thiamine, calcium, and iodine by Macao university students is significantly lower than the Chinese RNI.

Divergence in digestive and metabolic strategies matches habitat differentiation in juvenile salmonids.

Divergent energy acquisition and processing strategies associated with using different microhabitats may allow phenotypes to specialize and coexist at small spatial scales. To understand how ecological specialization affects differentiation in energy acquisition and processing strategies, we examined relationships among digestive physiology, growth, and energetics by performing captive experiments on juveniles of wild coho salmon (Oncorhynchus kisutch) and steelhead trout (O. mykiss) that exploit adjacent habitats along natural low‐to‐high energy flux gradients (i.e., pools versus riffles) in coastal streams. We predicted that: (i) the specialization of steelhead trout to high‐velocity, high‐energy habitats would result in elevated food intake and growth at the cost of lower growth efficiency relative to coho salmon; (ii) the two species would differentiate along a rate‐maximizing (steelhead trout) versus efficiency‐maximizing (coho salmon) axis of digestive strategies matching their ecological lifestyle; and (iii) the higher postprandial metabolic demand (i.e., specific dynamic action, SDA) associated with elevated food intake would occupy a greater fraction of the steelhead trout aerobic budget. Relative to coho salmon, steelhead trout presented a pattern of faster growth and higher food intake but lower growth efficiency, supporting the existence of a major growth versus growth efficiency trade‐off between species. After accounting for differences in ration size between species, steelhead trout also presented higher SDA than coho salmon, but similar intestinal transit time and lower assimilation efficiency. Both species presented similar aerobic budgets since the elevated SDA of steelhead trout was largely compensated by their higher aerobic scope relative to coho salmon. Our results illustrate the key contribution of digestive physiology to the adaptive differentiation of juvenile growth, energetics, and overall performance of taxa with divergent habitat specializations along a natural productivity gradient.