In this work, a novel universal multifunctional coating for insulation materials was prepared by using polyethyleneimine as the coating substrate, low-temperature molten glass powders and MXene as additives. Meanwhile, the universal coating was tightly adhered to the surface of the insulation materials through a surface activation strategy based on the synergistic effects of hydrogen bonding, electrostatic adsorption, and chemical bonding. The shear strength data showed that the adhesion between the universal coating and the three types of insulation material were higher than that of most commercial adhesives. In the case of EPDM, for example, the adhesion of the coating is 4.17 (epoxy glue), 1.04 (chemlok) and 1.67 (Neoprene) times that of commercial adhesives, respectively. In addition, the universal coating showed good heat resistance and thermal insulation, and formed a complete and dense char on the surface after exposure to flame. The maximum mass loss temperatures of the three coated insulation materials were 2.8, 6.5, and 9.3°C higher than the original samples, respectively. Thermal insulation tests showed that the coated insulation materials reduced the average top surface temperature by 29.68%, 40.84% and 29.06%, respectively, compared to the original samples. The results of anti-migration tests showed that the prepared universal coatings displayed generally superior anti-migration properties to the insulation materials, with equilibrium migration concentrations reduced by up to more than 80% compared to the original samples, which is better than the previous products of the same type. In addition, the application potential of the advanced multifunctional insulation materials obtained from the preparation was evaluated, resulting in an increase of more than 35% in peel strength and more than 20% in shear strength for all insulation materials with propellants. This work provides a simple and environmentally friendly generalized strategy to develop high performance insulation materials for aerospace fields.