The printed circuit heat exchanger (PCHE) is a high-efficiency and compact mini-channel heat exchanger. Due to the large number of fine channels, it is difficult to conduct the flow and heat transfer numerical simulation of the entire heat exchanger based on the actual channels, which requires a lot of computational resource and time. In this paper, a simplified multi-scale numerical method with a non-equilibrium porous media model (NOPM) is proposed to study the flow and heat transfer performance of PCHE at high temperature and pressure. The pressure field, velocity field and temperature field of NOPM and actual multi-channel model (MC) under different working conditions are compared to study the adaptability of NOPM for the PCHE. The results indicate that the NOPM can accurately predict the flow and heat transfer performance under PCHE configurations with a large number of channels. However, as the channel number decreases, the relative errors in the temperature and pressure prediction significantly increase due to the increased flow maldistribution. Similarly, the NOPM can well predict the overall temperature distribution of the PCHE solid when the channel number is numerous. This work could support accurate thermal design, and provide accurate temperature field for the thermal stress analysis of PCHE.