The paper is concerned with adaptive stabilization of a reaction-diffusion system governed by the Kuramoto-Sivashinsky equation (a non-linear partial differential equation). Under the existence of bounded deterministic disturbances, the adaptive stabilizer is constructed by the concept of high-gain non-linear output feedback and the estimation mechanism of the unknown parameters. In the control system, the global asymptotic stability and convergence of the system state to zero will be guaranteed. The problem of set point regulation is also considered.