High Frequency Oscillations Research Articles

Construction of semi-supervised spatial projections to identify the source of beta- and high frequency oscillations in Parkinson's disease.

Traditional deep brain stimulation (DBS) treatment for Parkinson's disease (PD) targets the placement of DBS leads into subthalamic nucleus (STN). Extraction of neurobiomarkers from STN local field potential activity can be used for the optimization of DBS. Beta (12-30 Hz) and high frequency oscillations (200-450 Hz, HFO) of STN and their phase-amplitude coupling have been previously correlated with symptom severity in PD. The typical approach is to take bipolar derivations of electrode contacts in order to enhance recordings of local brain activity and suppress noise levels. This approach can often cancel the signals in correlated neighboring contacts and create ambiguity in which monopolar contact to select for the identification of the main source of the oscillatory signal. To improve local specificity and help identify the source of beta and HFO in terms of electrode contact, we propose a semi supervised blind-source separation method. This approach presents a novel perspective to investigate electrophysiology by projecting the recorded channels into a subspace of virtual channels. We show the contribution of each channel to the identified source and correlate the spatial information with imaging and postoperative programming parameters. We anticipate such a source identification strategy can be used in the future to investigate the distribution of beta and HFO on individual contacts of the DBS lead and can improve the interpretation of these signals.

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

To test the feasibility and reliability of intracranial electrophysiological recordings in an acute status epilepticus model on laboratory swine. Intrahippocampal injection of kainic acid (KA) was performed on 17 male Bama pigs (Sus scrofa domestica) weighing between 25 and 35 kg. Two stereoelectroencephalography (SEEG) electrodes with a total of 16 channels were implanted bilaterally along the sensorimotor cortex to the hippocampus. Brain electrical activity was recorded 2 h daily for 9-28 days. Three KA dosages were tested to evaluate the quantities capable of evoking status epilepticus. Local field potentials (LFPs) were recorded and compared before and after the KA injection. We quantified the epileptic patterns, including the interictal spikes, seizures, and high-frequency oscillations (HFOs), up to 4 weeks after the KA injection. Test-retest reliability using intraclass correlation coefficients (ICCs) were performed on interictal HFO rates to evaluate the recording stability of this model. The KA dosage test suggested that a 10 μl (1.0 μg/μl) intrahippocampal injection could successfully evoke status epilepticus lasting from 4 to 12 h. At this dosage, eight pigs (50% of total) had prolonged epileptic events (tonic-chronic seizures + interictal spikes n = 5, interictal spikes alone n = 3) in the later 4 weeks of the video-SEEG recording period. Four pigs (25% of total) had no epileptic activities, and another four (25%) had lost the cap or did not complete the experiments. Animals that showed epileptiform events were grouped as E + (n = 8) and the four animals showing no signs of epileptic events were grouped as E- (n = 4). A total of 46 electrophysiological seizures were captured in the 4-week post-KA period from 4 E + animals, with the earliest onset on day 9. The seizure durations ranged from 12 to 45 s. A significant increase of hippocampal HFOs rate (num/min) was observed in the E+ group during the post-KA period (weeks 1, 2,4, p < 0.05) compared to the baseline. But the E-showed no change or a decrease (in week 2, p = 0.43) compared to their baseline rate. The between-group comparison showed much higher HFO rates in E + vs. E - (F = 35, p < 0.01). The high ICC value [ICC (1, k) = 0.81, p < 0.05] quantified from the HFO rate suggested that this model had a stable measurement of HFOs during the four-week post-KA periods. This study measured intracranial electrophysiological activity in a swine model of KA-induced mesial temporal lobe epilepsy (mTLE). Using the clinical SEEG electrode, we distinguished abnormal EEG patterns in the swine brain. The high test-retest reliability of HFO rates in the post-KA period suggests the utility of this model for studying mechanisms of epileptogenesis. The use of swine may provide satisfactory translational value for clinical epilepsy research.

Epileptic Tissue Localization through Skewness-Based Functional Connectivity in the High-Frequency Band of Intracranial EEG.

Functional connectivity analysis of intracranial electroencephalography (iEEG) plays an important role in understanding the mechanism of epilepsy and seizure dynamics. However, existing connectivity analysis is only suitable for low-frequency bands below 80 Hz. High-frequency oscillations (HFOs) and high-frequency activity (HFA) in the high-frequency band (80-500 Hz) are thought to be specific biomarkers in epileptic tissue localization. However, the transience in duration and variability of occurrence time and amplitudes of these events pose a challenge for conducting effective connectivity analysis. To deal with this problem, we proposed skewness-based functional connectivity (SFC) in the high-frequency band and explored its utility in epileptic tissue localization and surgical outcome evaluation. SFC comprises three main steps. The first step is the quantitative measurement of amplitude distribution asymmetry between HFOs/HFA and baseline activity. The second step is functional network construction on the basis of rank correlation of asymmetry across time. The third step is connectivity strength extraction from the functional network. Experiments were conducted in two separate datasets which consist of iEEG recordings from 59 patients with drug-resistant epilepsy. Significant difference (p<0.001) in connectivity strength was found between epileptic and non-epileptic tissue. Results were quantified via the receiver operating characteristic curve and the area under the curve (AUC). Compared with low-frequency bands, SFC demonstrated superior performance. With respect to pooled and individual epileptic tissue localization for seizure-free patients, AUCs were 0.66 (95% confidence interval (CI): 0.63-0.69) and (0.63 95% CI 0.56-0.71), respectively. For surgical outcome classification, the AUC was 0.75 (95% CI 0.59-0.85). Therefore, SFC can act as a promising assessment tool in characterizing the epileptic network and potentially provide better treatment options for patients with drug-resistant epilepsy.

PD23-03 IMPAIRED NITRIC OXIDE MECHANISMS UNDERLYING LOWER URINARY TRACT DYSFUNCTION IN AGING RATS

You have accessJournal of UrologyCME1 Apr 2023PD23-03 IMPAIRED NITRIC OXIDE MECHANISMS UNDERLYING LOWER URINARY TRACT DYSFUNCTION IN AGING RATS Daisuke Gotoh, Kenta Onishi, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Fujimoto Kiyohide, and Naoki Yoshimura Daisuke GotohDaisuke Gotoh More articles by this author , Kenta OnishiKenta Onishi More articles by this author , Yosuke MorizawaYosuke Morizawa More articles by this author , Shunta HoriShunta Hori More articles by this author , Yasushi NakaiYasushi Nakai More articles by this author , Makito MiyakeMakito Miyake More articles by this author , Kazumasa TorimotoKazumasa Torimoto More articles by this author , Fujimoto KiyohideFujimoto Kiyohide More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003296.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Nitric oxide (NO) promotes the intracellular production of cyclic guanosine monophosphate (cGMP) in smooth muscles, reduces the intracellular calcium concentration, and enhances smooth muscle relaxation. However, it remains unknown whether changes in the expression of NO-related molecules are associated with the development of lower urinary tract dysfunction (LUTD) with age. Therefore, we examined changes in bladder and urethral activities, and in NO-related molecule expression using aging rats. METHODS: Fourteen Female Sprague–Dawley rats were divided into two age groups: (A) young rats (12 weeks old, n=8) and (B) aging rats (15 months old, n=6). In both groups, 24 h voiding assay was performed, and the urodynamic parameters were evaluated using cystometry (CMG) and urethral perfusion pressure (UPP) recordings. mRNA expression levels of NO-, ischemia-, and inflammation-related markers in bladder and urethra tissues were assessed, and the cGMP level in the urethra was measured. RESULTS: There was no significant difference in the 24-h voiding assay results between the groups. In CMG, the number of non-voiding contractions (NVCs) per voiding cycle and post-void residual (PVR) were significantly higher, and voiding efficiency (VE) was significantly lower in Group B than in Group A (Figure 1A, B). In the UPP recordings, urethral pressure (UP) reduction and high frequency oscillation (HFO) amplitudes were both significantly lower in Group B than in Group A (Figure 1C, D). In molecular studies, mRNA expression levels of HIF-1α, VEGF, and TGF-β1 in the bladder were significantly higher in Group B than in Group A (Figure 2A). mRNA expression levels of NOS1 and PKG were significantly lower in Group B than in Group A (Figure 2B). In addition, the concentration of cGMP in the urethra was significantly lower in Group B than in Group A (Figure 2C). CONCLUSIONS: Aging rats would be a useful model for the study of the natural progression of age-related LUTD, for which impaired NO-mediated transmitter function is likely to be an important mechanism. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e671 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Daisuke Gotoh More articles by this author Kenta Onishi More articles by this author Yosuke Morizawa More articles by this author Shunta Hori More articles by this author Yasushi Nakai More articles by this author Makito Miyake More articles by this author Kazumasa Torimoto More articles by this author Fujimoto Kiyohide More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...

Nonlinear model and characteristic analysis of fractional-order high frequency oscillator

Recently, fractional calculus theory has been widely used in various fields, including the design of oscillators. However, there are still some issues that need to be studied in depth. Firstly, it is necessary to classify the fractional-order oscillators according to the properties of the frequency selective network components, and analyze the influence of the fractional order of components on the characteristics of different types of fractional-order oscillators. Secondly, for fractional-order oscillators with nonlinear devices such as transistors, the traditional linear models cannot describe them accurately. Thirdly, due to the complexity of fractional differential equation, it is difficult to obtain the general analytical solution of the fractional-order oscillator. For these reasons, this paper takes the fractional-order capacitive feedback LC oscillator as an example, and establishes a nonlinear model of this oscillator based on the transistor characteristic mechanism. With the help of the equivalent small parameter method, the influence of the fractional-order characteristics of the components on the output waveform is analyzed. It is revealed that for the fractional-order capacitive feedback LC oscillator, the order of capacitance C1 has the most significant effect on frequency and amplitude, followed by the order of inductance L2, and the order of the feedback capacitor C2 has very little effect on the oscillator. In addition, although the introduction of fractional order increases the oscillation frequency, it will also lead to an increase in THD in some cases. Simulation and experimental results verify the correctness of the proposed nonlinear model and characteristic analysis of fractional-order high frequency oscillator.

Detection of pathological high-frequency oscillations in refractory epilepsy patients undergoing simultaneous stereo-electroencephalography and magnetoencephalography

BackgroundStereo-electroencephalography (SEEG) and magnetoencephalography (MEG) have generally been used independently as part of the pre-surgical evaluation of drug-resistant epilepsy (DRE) patients. However, the possibility of simultaneously employing these recording techniques to determine whether MEG has the potential of offering the same information as SEEG less invasively, or whether it could offer a greater spatial indication of the epileptogenic zone (EZ) to aid surgical planning, has not been previously evaluated. MethodsData from 24 paediatric and adult DRE patients, undergoing simultaneous SEEG and MEG as part of their pre-surgical evaluation, was analysed employing manual and automated high-frequency oscillations (HFOs) detection, and spectral and source localisation analyses. ResultsTwelve patients (50%) were included in the analysis (4 males; mean age=25.08 years) and showed interictal SEEG and MEG HFOs. HFOs detection was concordant between the two recording modalities, but SEEG displayed higher ability of differentiating between deep and superficial epileptogenic sources. Automated HFO detector in MEG recordings was validated against the manual MEG detection method. Spectral analysis revealed that SEEG and MEG detect distinct epileptic events. The EZ was well correlated with the simultaneously recorded data in 50% patients, while 25% patients displayed poor correlation or discordance. ConclusionMEG recordings can detect HFOs, and simultaneous use of SEEG and MEG HFO identification facilitates EZ localisation during the presurgical planning stage for DRE patients. Further studies are necessary to validate these findings and support the translation of automated HFO detectors into routine clinical practice.

The motion of a layer of yield-stress material on an oscillating plate

The motion of a finite layer of Bingham material on a solid plate that executes in-plane oscillations was reported previously by Balmforth et al. (J. Non-Newtonian Fluid Mech., vol. 158, issue 1–3, 2009, pp. 46–53). There, it was suggested that multiple yielded regions may arise within the material; this contrasts to start-up flow of the same material for which only one yielded region is generated. Here, we explore quantitatively the fluid physics of this oscillatory flow problem through analytical approximations and further numerical computation. Four new key topological properties concerning the generation and termination of the yielded regions are reported. It is shown that the existence of multiple yielded regions is equivalent to the layer never becoming entirely rigid during the periodic motion. For small inertia, the flow is approximately time-reversible with only a single yielded region generated at the plate. For large inertia, shear stress in the material decays rapidly as a function of distance from the plate. A thin zone of yielded material detaches periodically from the plate, and subsequently terminates within the layer. At high oscillation frequency, there can be any number $N$ of distinct rigid regions, satisfying $N= \lfloor 1- {\rm \pi}^{-1} \log B \rfloor$ where $B$ is the Bingham number. It is also shown that for $B&gt;0.5370$ , there are at most one yielded region and one rigid region throughout the motion. These theoretical results can be used as a basis for oscillatory rheometry, allowing for measurement of the yield stress using existing apparatus.

Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas

ObjectiveTo determine how sevoflurane anesthesia modulates intraoperative epilepsy biomarkers on electrocorticography, including high-frequency oscillation (HFO) effective connectivity (EC), and to investigate their relation to epileptogenicity and anatomical white matter. MethodsWe studied eight pediatric drug-resistant focal epilepsy patients who achieved seizure control after invasive monitoring and resective surgery. We visualized spatial distributions of the electrocorticography biomarkers at an oxygen baseline, three time-points while sevoflurane was increasing, and at a plateau of 2 minimum alveolar concentration (MAC) sevoflurane. HFO EC was combined with diffusion-weighted imaging, in dynamic tractography. ResultsIntraoperative HFO EC diffusely increased as a function of sevoflurane concentration, although most in epileptogenic sites (defined as those included in the resection); their ability to classify epileptogenicity was optimized at sevoflurane 2 MAC. HFO EC could be visualized on major white matter tracts, as a function of sevoflurane level. ConclusionsThe results strengthened the hypothesis that sevoflurane-activated HFO biomarkers may help intraoperatively localize the epileptogenic zone. SignificanceOur results help characterize how HFOs at non-epileptogenic and epileptogenic networks respond to sevoflurane. It may be warranted to establish a normative HFO atlas incorporating the modifying effects of sevoflurane and major white matter pathways, as critical reference in epilepsy presurgical evaluation.

Glutamatergic and GABAergic Receptor Modulation Present Unique Electrophysiological Fingerprints in a Concentration-Dependent and Region-Specific Manner.

Brain function depends on complex circuit interactions between excitatory and inhibitory neurons embedded in local and long-range networks. Systemic GABAA-receptor (GABAAR) or NMDA-receptor (NMDAR) modulation alters the excitatory-inhibitory balance (EIB), measurable with electroencephalography (EEG). However, EEG signatures are complex in localization and spectral composition. We developed and applied analytical tools to investigate the effects of two EIB modulators, MK801 (NMDAR antagonist) and diazepam (GABAAR modulator), on periodic and aperiodic EEG features in freely-moving male Sprague Dawley rats. We investigated how, across three brain regions, EEG features are correlated with EIB modulation. We found that the periodic component was composed of seven frequency bands that presented region-dependent and compound-dependent changes. The aperiodic component was also different between compounds and brain regions. Importantly, the parametrization into periodic and aperiodic components unveiled correlations between quantitative EEG and plasma concentrations of pharmacological compounds. MK-801 exposures were positively correlated with the slope of the aperiodic component. Concerning the periodic component, MK-801 exposures correlated negatively with the peak frequency of low-γ oscillations but positively with those of high-γ and high-frequency oscillations (HFOs). As for the power, θ and low-γ oscillations correlated negatively with MK-801, whereas mid-γ correlated positively. Diazepam correlated negatively with the knee of the aperiodic component, positively to β and negatively to low-γ oscillatory power, and positively to the modal frequency of θ, low-γ, mid-γ, and high-γ. In conclusion, correlations between exposures and pharmacodynamic effects can be better-understood thanks to the parametrization of EEG into periodic and aperiodic components. Such parametrization could be key in functional biomarker discovery.

Experimental Investigations on Wear in Oscillating Grease-Lubricated Rolling Element Bearings of Different Size and Type

Grease-lubricated rolling element bearings can suffer from wear due to lubricant starvation under certain oscillating operating conditions. Especially for large-scale slewing bearings, such as blade bearings in wind turbines, experimental investigations are complex compared to small-scale reference testing. For an easier manner of testing, it is desirable to know whether the results of small-scale testing are applicable to larger-sized bearings. In this work, three different bearing types were tested and compared to already published results from a small-scale ACBB with a pitch diameter of 60 mm. The newly tested bearing types comprise a downscaled blade bearing (4-point contact double row ball bearing) with a pitch diameter of 673 mm, a small-scale CRTB with a pitch diameter of 77.5 mm and another ACBB with a pitch diameter of 95 mm. Qualitatively, all tested bearings show similar wear behaviour in terms of friction energy when operation parameters are varied. With higher oscillation frequency, damage becomes more severe. The oscillation amplitude shows three distinctive regimes. Within the range of small amplitudes, an increase in amplitude leads to more pronounced damage. We observe a threshold amplitude where this is no longer the case; a further increase in amplitude counteracts wear initiation until a final threshold is reached, beyond which no more wear is observed. These findings are in accordance with the reference results of the small-scale ACBB. Direct comparison between point and line contact shows that the latter is more prone to wear initiation under grease-lubricated, oscillating operating conditions. Furthermore, a previously introduced empirical number shows good performance in assessing critical operating parameters of the different bearing types. Specifically, harmful operating conditions can be classified for all studied bearing types with an accuracy of 78%. This method can be useful to assess operating conditions of greased, oscillating, rolling element bearings, e.g., to assess different pitch controllers or designs of slewing bearings.

P-128 Low impedance electrodes improve detection of high frequency oscillations in intracranial EEG

P-128 Low impedance electrodes improve detection of high frequency oscillations in intracranial EEG

Hemodynamic Effects of a High-Frequency Oscillatory Ventilation Open-Lung Strategy in Critically Ill Children With Acquired or Congenital Cardiac Disease.

To study the hemodynamic consequences of an open-lung high-frequency oscillatory ventilation (HFOV) strategy in patients with an underlying cardiac anomaly with or without intracardiac shunt or primary pulmonary hypertension with severe lung injury. Secondary analysis of prospectively collected data. Medical-surgical PICU. Children less than 18 years old with cardiac anomalies (± intracardiac shunt) or primary pulmonary hypertension. None. Data from 52 subjects were analyzed, of whom 39 of 52 with cardiac anomaly (23/39 with intracardiac shunt) and 13 of 52 with primary pulmonary hypertension. Fourteen patients were admitted postoperatively, and 26 patients were admitted with acute respiratory failure. Five subjects (9.6%) were canulated for ECMO (of whom four for worsening respiratory status). Ten patients (19.2%) died during PICU stay. Median conventional mechanical ventilation settings prior to HFOV were peak inspiratory pressure 30 cm H 2 O (27-33 cm H 2 O), positive end-expiratory pressure 8 cm H 2 O (6-10 cm H 2 O), and F io2 0.72 (0.56-0.94). After transitioning to HFOV, there was no negative effect on mean arterial blood pressure, central venous pressure, or arterial lactate. Heart rate decreased significantly over time ( p < 0.0001), without group differences. The percentage of subjects receiving a fluid bolus decreased over time ( p = 0.003), especially in those with primary pulmonary hypertension ( p = 0.0155) and without intracardiac shunt ( p = 0.0328). There were no significant differences in the cumulative number of daily boluses over time. Vasoactive Infusion Score did not increase over time. Pa co2 decreased ( p < 0.0002) and arterial pH significantly improved ( p < 0.0001) over time in the whole cohort. Neuromuscular blocking agents were used in all subjects switched to HFOV. Daily cumulative sedative doses were unchanged, and no clinically apparent barotrauma was found. No negative hemodynamic consequences occurred with an individualized, physiology-based open-lung HFOV approach in patients with cardiac anomalies or primary pulmonary hypertension suffering from severe lung injury.

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone.

High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency oscillations, and the existing detectors vary in methodology, performance, and computational costs. This study proposes relative entropy as an easy-to-use novel interictal biomarker of the epileptic tissue. We evaluated relative entropy and high-frequency oscillation biomarkers on intracranial electroencephalographic data from 39 patients with seizure-free postoperative outcome (Engel Ia) from three institutions. We tested their capability to localize the epileptogenic zone, defined as resected contacts located in the seizure onset zone. The performance was compared using areas under the receiver operating curves (AUROCs) and precision-recall curves. Then we tested whether a universal threshold can be used to delineate the epileptogenic zone across patients from different institutions. Relative entropy in the ripple band (80-250 Hz) achieved an average AUROC of .85. The normalized high-frequency oscillation rate in the ripple band showed an identical AUROC of .85. In contrast to high-frequency oscillations, relative entropy did not require any patient-level normalization and was easy and fast to calculate due to its clear and straightforward definition. One threshold could be set across different patients and institutions, because relative entropy is independent of signal amplitude and sampling frequency. Although both relative entropy and high-frequency oscillations have a similar performance, relative entropy has significant advantages such as straightforward definition, computational speed, and universal interpatient threshold, making it an easy-to-use promising biomarker of the epileptogenic zone.

Mitigation of Oscillations in Three Phase LCL-Filtered Grid Converters Based on Proportional Resonance and Improved Model Predictive Control

For three phase <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LCL</i> -filtered gird converters, this paper designs a robust control strategy to reduce high frequency and subsynchronous or supersynchronous oscillations. Two components, namely the grid side inductor component and the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> filter component, constitute a three phase <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LCL</i> -filtered grid converter. Model predictive control (MPC) with a disturbance observer is used to control the interconnection voltage of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> filter. Proportional resonance (PR) control regulates the grid side current. It is possible to combine MPC with PR's advantages. The dynamic performance is enhanced by MPC's intrinsic ability to achieve active damping without extra control and reduce modulation latency. In addition to achieving zero steady state error, PR control greatly simplifies the control process when compared to the overall MPC of the entire grid converter. By analyzing the frequency response of the transfer function and output impedance, it is possible to determine that the proposed control has a sufficient phase margin and that, even when the system and control parameters change, the grid converters’ output impedance is always resistive or inductive at the entire frequency, suppressing subsynchronous and high frequency oscillations. To further reduce the oscillations and harmonics, an improved MPC control framework and a feedback compensation mechanism are proposed. The effectiveness and reliability of the proposed control in current tracking, harmonic suppression, and response to grid impedance variations are verified by comparative analysis of simulation results.

Nonlinear Theta-Gamma Coupling between the Anterior Thalamus and Hippocampus Increases as a Function of Running Speed.

The hippocampal theta rhythm strongly correlates to awake behavior leading to theories that it represents a cognitive state of the brain. As theta has been observed in other regions of the Papez circuit, it has been theorized that activity propagates in a reentrant manner. These observations complement the energy cascade hypothesis in which large-amplitude, slow-frequency oscillations reflect activity propagating across a large population of neurons. Higher frequency oscillations, such as gamma, are related to the speed with which inhibitory and excitatory neurons interact and distribute activity on the local level. The energy cascade hypothesis suggests that the larger anatomic loops, maintaining theta, drive the smaller loops. As hippocampal theta increases in power with running speed, so does the power and frequency of the gamma rhythm. If theta is propagated through the circuit, it stands to reason that the local field potential (LFP) recorded in other regions would be coupled to the hippocampal theta, with the coupling increasing with running speed. We explored this hypothesis using open-source simultaneous recorded data from the CA1 region of the hippocampus and the anterior dorsal and anterior ventral thalamus. Cross-regional theta coupling increased with running speed. Although the power of the gamma rhythm was lower in the anterior thalamus, there was an increase in the coupling of hippocampal theta to anterior thalamic gamma. Broadly, the data support models of how activity moves across the nervous system, suggesting that the brain uses large-scale volleys of activity to support higher cognitive processes.

Coseismic site response and slope instability using periodic boundary conditions in the material point method

This paper proposed the explicit generalized-α time scheme and periodic boundary conditions in the material point method (MPM) for the simulation of coseismic site response. The proposed boundary condition uses an intuitive particle-relocation algorithm ensuring material points always remain within the computational mesh. The explicit generalized-α time scheme was implemented in MPM to enable the damping of spurious high frequency oscillations. Firstly, the MPM was verified against finite element method (FEM). Secondly, ability of the MPM in capturing the analytical transfer function was investigated. Thirdly, a symmetric embankment was adopted to investigate the effects of ground motion arias intensity (Ia), geometry dimensions, and constitutive models. The results show that the larger the model size, the higher the crest runout and settlement for the same ground motion. When using a Mohr-Coulomb model, the crest runout increases with increasing Ia. However, if the strain-softening law is activated, the results are less influenced by the ground motion. Finally, the MPM results were compared with the Newmark sliding block solution. The simplified analysis herein highlights the capabilities of MPM to capture the full deformation process for earthquake engineering applications, the importance of geometry characterization, and the selection of appropriate constitutive models when simulating coseismic site response and subsequent large deformations.

A 267 GHz Wide Tuning Range VCO With −3.5 dBm Peak Output Power in 40-nm CMOS

This article presents a highly efficient, wide tuning range push-push voltage-controlled oscillator (VCO) in the sub-terahertz frequency band. The proposed VCO adopted a novel capacitance-splitting feedback technique to achieve high oscillation frequency and output power. The frequency tuning is provided through a tunable source degeneration (TSD) network. The proposed TSD network enables a wide tuning range without substantially sacrificing output power. The proposed VCO is fabricated in a 40-nm complementary metal-oxide-semiconductor (CMOS) process and has a peak output power of −3.5 dBm, a center frequency of 267.2 GHz, and a continuous tuning range of 27 GHz. The VCO consumes 30 mA current from a 1.1 V dc supply, resulting in 1.35% dc-to-RF efficiency.

The association of magnetoencephalography high-frequency oscillations with epilepsy types and a ripple-based method with source-level connectivity for mapping epilepsy sources.

To explore the association between high-frequency oscillations (HFOs) and epilepsy types and to improve the accuracy of source localization. Magnetoencephalography (MEG) ripples of 63 drug-resistant epilepsy patients were detected. Ripple rates, distribution, spatial complexity, and the clustering coefficient of ripple channels were used for the preliminary classification of lateral temporal lobe epilepsy (LTLE), mesial temporal lobe epilepsy (MTLE), and nontemporal lobe epilepsy (NTLE), mainly frontal lobe epilepsy (FLE). Furthermore, the seizure site identification was improved using the Tucker LCMV method and source-level betweenness centrality. Ripple rates were significantly higher in MTLE than in LTLE and NTLE (p < 0.05). The LTLE and MTLE were mainly distributed in the temporal lobe, followed by the parietal lobe, occipital lobe, and frontal lobe, whereas MTLE ripples were mainly distributed in the frontal lobe, then parietal lobe and occipital lobe. Nevertheless, the NTLE ripples were primarily in the frontal lobe and partially in the occipital lobe (p < 0.05). Meanwhile, the spatial complexity of NTLE was significantly higher than that of LTLE and MTLE and was lowest in MTLE (p < 0.01). However, an opposite trend was observed for the standardized clustering coefficient compared with spatial complexity (p < 0.01). Finally, the tucker algorithm showed a higher percentage of ripples at the surgical site when the betweenness centrality was added (p < 0.01). This study demonstrated that HFO rates, distribution, spatial complexity, and clustering coefficient of ripple channels varied considerably among the three epilepsy types. Additionally, tucker MEG estimation combined with ripple rates based on the source-level functional connectivity is a promising approach for presurgical epilepsy evaluation.

Tectono-sedimentary characteristics and controlling factors of the lower-middle Cambrian gypsum-salt rocks in the Tarim Basin, Northwest China

Due to their excellent sealing capacity, gypsum-salt rocks are often associated with hydrocarbon accumulations. In the Tarim Basin (Northwest China), exploration activity has demonstrated that the Cambrian gypsum-salt rocks played a key role in the development of hydrocarbon plays, but there is still a lack of research on them. This study utilizes geological data coming from outcrops, well logs, rock cores, and seismic reflection profiles to quantify the distribution and tectono-sedimentary characteristics of the Cambrian gypsum-salt rocks in the Tarim Basin, and decipher the controlling factors governing their deposition. The gypsum-salt rocks are present in the Lower Cambrian Wusonger and the Middle Cambrian Awatage Formations, which are distributed around the Aman and Awati depressions, two structures inherited from the Ediacaran intracontinental rift, and the Bachu uplift. These Formations are mainly composed of salt, gypsum, gypsum halite, gypsum dolomite and gypsum mudstone, and are usually deposited in medium-thin beds. The total and single layer thicknesses of gypsum-salt rocks in the north of Bachu uplift are greater than that in the south. These lithofacies can be associated with different environments of deposition, with the Bachu uplift interpreted as supratidal sabkhas and evaporation lagoons and the Aman-Awati depressions as large-scale evaporation salt basins with a bull's eye architecture of halite-gypsum-dolomite. Carbon and oxygen isotopes indicate an overall fall in relative sea level from the late Early Cambrian to the Middle Cambrian in the Tarim Basin, accompanied by higher-frequency oscillations. Influenced by this continuous decline of sea level, the eastern platform margin transformed from gentle ramp to progradational rimmed margin and blocked the water exchange between the open sea and the platform. The southwest side of the platform was characterized by a stable gentle ramp margin, which was flooded by seawater during rise of sea level. In addition, the development of the intraplatform shoals further provided morphological barriers for the lagoons in the Bachu-Tazhong uplift belt. The Aman-Awati depressions continued to subside during the Early and Middle Cambrian and became the main loci of salt deposition, whereas the depressions and half grabens formed under the tensile tectonic regime in the Bachu-Tazhong uplift belt controlled the development of evaporation lagoons and gypsum-salt flats. This study constrained the distribution and evolution of gypsum-salt caprocks, and thus provide new insights for the sub-salt and inter-salt hydrocarbon exploration in the Tarim Basin.

Three-dimensional modeling and simulation of RF cavity for a transmitter with bandwidth of 40–100 MHz at 100-kilowatt level

A 1.5 MW final power amplifier is to be developed for ion cyclotron resonance heating (ICRH) system for the China fusion engineering testing reactor (CFETR) project. First, the feasibility of driver power amplifier with input matching circuit and output resonator cavity and a newly developed tetrode was cross-verified through three-dimensional (3D) simulations and experiments. A single coaxial cavity in parallel with the tetrode covered the frequency range of 40 to 100 MHz at a 100-kilowatt level. In contrast to the previous method of deducing matching parameters using RF circuit and transmission line theory, the use of 3D transmitter simulations provided more accurate matching parameters of tuning components at different operating frequencies. A new phenomenon of high frequency oscillation between the short strip inductor and the shield cavity was found in the input simulation results, which was subsequently verified by experiments. Specific reasons for dividing the output into two parts of high and low frequency were found through output circuit simulations. One is that the length of short stub decreases with the increase of operating frequency, thus decreasing the frequency resolution if all frequencies were using low frequency port. The other is that the coupling capacitor increases sharply with the increase of frequency due to parasitic effect in the low output. Further, the simulation facilitated the study of parasitic effects on matching parameters caused by strip-inductance, inter electrode capacitances of tetrode, and RF cavity. Thus, facilitating the design of final power amplifier in the future. Finally, the amplifier installed with the new tetrode DB968 achieved the design objectives in the test experiment with 150 and 110 kW power outputs at 48 and 100 MHz, respectively.