With the rapid development of all walks of life, heat exchangers have been used all over the various fields. Plate fin heat exchanger was concerned, because of its high heat transfer rate and the small size. Among them, the offset strip fin is called “high efficiency fin” because its special staggered arrangement structure can increase the turbulent flow of fluid and enhance heat transfer. In order to study the influence of flow and heat transfer in dislocation fins, the three-dimensional numerical simulation of LPD dislocation fins is carried out by numerical simulation. Firstly, the accuracy of the standard laminar flow model is verified by using the dislocation fins and experimental data provided by the literature. The average error between the calculated value of the heat transfer factor and the experimental value is 5.95%, and the average error between the calculated value and the experimental value of the friction factor is 2.02%. On this basis, the influence of flow parameters and structural parameters on the internal flow and heat transfer in the dislocation fins is analyzed.The results show that: (1) the smaller the fluid velocity, the lower the height of the dislocation fin; the smaller the tooth angle, the shorter the cut length; the greater the heat transfer factor j, the better the heat transfer performance;(2) The higher the fluid velocity, the higher the height of the dislocation fin, the smaller the tooth angle; the shorter the cut length, the smaller the friction factor f, the better the resistance characteristic;(3) the lower the fin height, the smaller the tooth angle; the shorter the cut length, the greater the temperature difference and the pressure drop with the length of the heat transfer section; the fin height has little effect on the velocity field, The flow distribution of the fluid flow in the flow channel is affected, the shorter the cutting length is, the faster the velocity field changes.