High FBS Research Articles

Aflatoxins and fumonisins co-contamination effects on laying hens and use of mycotoxin detoxifiers as a mitigation strategy.

This study examined the effects of fumonisins (FBs) and aflatoxin B1 (AFB1), alone or in combination, on the productivity and health of laying hens, as well as the transfer of aflatoxins (AFs) to chicken food products. The efficacy and safety of mycotoxin detoxifiers (bentonite and fumonisin esterase) to mitigate these effects were also assessed. Laying hens (400) were divided into 20 groups and fed a control, moderate (54.6µg/kg feed) or high (546µg/kg feed) AFB1 or FBs (7.9mg/kg feed) added diets, either alone or in combination, with the mycotoxin detoxifiers added in selected diets. Productivity was evaluated by feed intake, egg weight, egg production, and feed conversion ratio whereas health was assessed by organ weights, blood biochemistry, and mortality. Aflatoxins residues in plasma, liver, muscle, and eggs were determined using UHPLC-MS/MS methods. A diet with AFB1 at a concentration of 546µg/kg feed decreased egg production and various AFB1-contaminated diets increased serum uric acid levels and weights of liver, spleen, heart, and gizzard. Interactions between AFB1 and FBs significantly impacted spleen, heart, and gizzard weights as well as AFB1 residues in eggs. Maximum AFB1 residues of 0.64µg/kg and aflatoxin M1 (below limits of quantification) were observed in liver, plasma, and eggs of layers fed diets with AFB1. The mycotoxin detoxifiers reduced effects of AFB1 and FBs on egg production, organ weights, blood biochemistry, and AFB1 residues in tissues. This study highlights the importance of mycotoxin detoxifiers as a mitigation strategy against mycotoxins in poultry production.

Understanding the Association Between Type 2 Diabetes Mellitus and Cognitive Impairment: A Single-centre Experience

Background The global prevalence of diabetes mellitus has been increasing, leading to a rise in morbidity associated with the disease. While diabetic nephropathy, retinopathy and neuropathy are routinely screened in diabetic patients, the cognitive decline associated with diabetes is often overlooked. Purpose The purpose of this study is to investigate the prevalence of cognitive impairment and its associated risk factors among patients with type 2 diabetes mellitus (T2DM). Methods An observational cross-sectional study was conducted for two months. The Montreal Cognitive Assessment (MoCA) test, which consists of 30 questions, was used to assess cognitive function. In-depth clinical history along with glycaemic parameters were collected. The chi-square test was used to find out the association between categorical variables and cognitive impairment. Pearson’s correlation test was performed to determine the correlation between glycaemic parameters and cognitive impairment. Results A total of 96 patients participated in the study. The mean HbA1c (%) was 9.08 ± 1.73, and the mean MoCA score was 25.14 ± 1.63. Mild cognitive impairment (MCI) was noted in 56% patients. Attention was the most common cognitive domain defect found in all MCI patients—100%. Delayed recall and memory were the second most common cognitive domain defect found—92.5%. Higher HbA1c, high FBS and higher PPBS were found to be statistically associated with MCI. A negative correlation was found between glycaemic parameters (HbA1c, FBS and PPBS levels) and MoCA scores. Conclusion More than half of our study participants reported mild cognitive impairment. It highlights the need for the implementation of routine cognitive testing for diabetes patients. There is a strong negative correlation between MoCA scores and parameters of glycaemic control; higher levels of HbA1c, FBS, and PPBS are seen in people with a lower MoCA score, indicating mild cognitive impairment. Further studies are needed to evaluate whether improving glucose levels helps in improving cognition or not.

White blood cell and platelet distribution widths are associated with hypertension: data mining approaches.

In this paper, we are going to investigate the association between Hypertension (HTN) and routine hematologic indices in a cohort of Iranian adults. The data were obtained from a total population of 9704 who were aged 35-65 years, a prospective study was designed. The association between hematologic factors and HTN was assessed using logistic regression (LR) analysis and a decision tree (DT) algorithm. A total of 9704 complete datasets were analyzed in this cohort study (N = 3070 with HTN [female 62.47% and male 37.52%], N = 6634 without HTN [female 58.90% and male 41.09%]). Several variables were significantly different between the two groups, including age, smoking status, BMI, diabetes millitus, high sensitivity C-reactive protein (hs-CRP), uric acid, FBS, total cholesterol, HGB, LYM, WBC, PDW, RDW, RBC, sex, PLT, MCV, SBP, DBP, BUN, and HCT (P < 0.05). For unit odds ratio (OR) interpretation, females are more likely to have HTN (OR = 1.837, 95% CI = (1.620, 2.081)). Among the analyzed variables, age and WBC had the most significant associations with HTN OR = 1.087, 95% CI = (1.081, 1.094) and OR = 1.096, 95% CI = (1.061, 1.133), respectively (P-value < 0.05). In the DT model, age, followed by WBC, sex, and PDW, has the most significant impact on the HTN risk. Ninety-eight percent of patients had HTN in the subgroup with older age (≥58), high PDW (≥17.3), and low RDW (<46). Finally, we found that elevated WBC and PDW are the most associated factor with the severity of HTN in the Mashhad general population as well as female gender and older age.

Effects of Aflatoxins and Fumonisins, Alone or in Combination, on Performance, Health, and Safety of Food Products of Broiler Chickens, and Mitigation Efficacy of Bentonite and Fumonisin Esterase.

The current study evaluated the effects of feeding diets contaminated with aflatoxin B1 (AFB1), fumonisins (FBs), or both on the performance and health of broiler chickens and the safety of their food products as well as the efficacy of bentonite and fumonisin esterase to mitigate the effects of these mycotoxins under conditions representative for sub-Saharan Africa (SSA). Four hundred one-day-old Cobb 500 broiler chickens were randomly assigned to 20 treatments with either a control diet, a diet with moderate AFB1 (60 μg/kg feed) or high AFB1 (220 μg/kg feed), or FBs (17,430 μg FB1+FB2/kg feed), alone or in combination, a diet containing AFB1 (either 60 or 220 μg/kg) and/or FBs (17,430 μg FB1+FB2/kg) and bentonite or fumonisin esterase or both, or a diet with bentonite or fumonisin esterase only. The experimental diets were given to the birds from day 1 to day 35 of age, and the effects of the different treatments on production performance were assessed by feed intake (FI), body weight gain (BWG), and feed conversion ratio (FCR). Possible health effects were evaluated through blood biochemistry, organ weights, mortality, liver gross pathological changes, and vaccine response. Residues of aflatoxins (AFB1, B2, G1, G2, M1 and M2) were determined in plasma, muscle, and liver tissues using validated UHPLC-MS/MS methods. The results obtained indicated that broiler chickens fed high AFB1 alone had poor FCR when compared to a diet with both high AFB1 and FBs (p = 0.0063). Serum total protein and albumin from birds fed FBs only or in combination with moderate or high AFB1 or detoxifiers increased when compared to the control (p < 0.05). Liver gross pathological changes were more pronounced in birds fed contaminated diets when compared to birds fed the control or diets supplemented with mycotoxin detoxifiers. The relative weight of the heart was significantly higher in birds fed high AFB1 and FBs when compared to the control or high AFB1 only diets (p < 0.05), indicating interactions between the mycotoxins. Inclusion of bentonite in AFB1-contaminated diets offered a protective effect on the change in weights of the liver, heart and spleen (p < 0.05). Residues of AFB1 were detected above the limit of quantification (max: 0.12 ± 0.03 μg/kg) in liver samples only, from birds fed a diet with high AFB1 only or with FBs or the detoxifiers. Supplementing bentonite into these AFB1-contaminated diets reduced the levels of the liver AFB1 residues by up to 50%. Bentonite or fumonisin esterase, alone, did not affect the performance and health of broiler chickens. Thus, at the doses tested, both detoxifiers were safe and efficient for use as valid means of counteracting the negative effects of AFB1 and FBs as well as transfer of AFB1 to food products (liver) of broiler chickens.

ASSOCIATION OF URIC ACID WITH COMPONENTS OF METABOLIC SYNDROME AT A TERTIARY CARE CENTRE IN BENGALURU

Background: Metabolic syndrome (MetS) is also known as syndrome X, insulin resistance syndrome is dened as a group of disease developed due to accumulation of multiple risk factors that includes resistance to insulin, dyslipidemia, abdominal obesity and hypertension. Metabolic syndrome, is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with many other systemic disorders such as cerebrovascular accident, chronic lung disease and fatty liver disease. Hyperuricemia (above 7.0 mg/dL in men and 6.0 mg/dL in women) has been reported to be closely related to diabetes, hypertension, obesity, renal function decline, and cardiovascular disease, most of which are principal contributors in the development and progression of MetS. The study aimed to assess the associations of serum uric acid with the components of MetS. Methods: This cross-sectional study was conducted in the hospitals attached to Bangalore medical college and research Institute. 110 patients with metabolic syndrome who satised the inclusion criteria were included. Data was collected in the form of history, clinical examination, and relevant investigations. Statistical analysis was performed using SPSS software, p value of &lt;0.5 being signicant Results: The mean age of the study participants was found to be 51.55+7.760 years of age. 62.7% of the study participants were males The mean serum uric acid level of the study participants was found to be 6.325+2.7910. 41.82% of the study participants who had metabolic syndrome had hyperuricemia. The association was found to be statistically signicant between hyperuricemia and hypertension, central obesity, low HDL, high FBS among the study participants. Conclusions: Serum uric acid is closely associated with metabolic syndrome and its components. Serum uric acid can also be considered as a mandatory investigation in patients who has any of the ve components of metabolic syndrome

A STUDY ON PREVALENCE OF HYPOTHYROIDISM (CLINICAL/SUBCLINICAL) IN DIABETES MELLITUS AND CORRELATION OF HbA1C LEVELS WITH TSH LEVELS IN WESTERN UTTAR PRADESH

Background and Aims: Patients with type 2 diabetes mellitus are more prone to thyroid disorders. Hypothyroidism The aim of this study was to study the prevalence of Hypothyroidism (Clinical/Subclinical) in Diabetic patients and to study the correlation of HbA1c levels with TSH levels. This is a prospective Methods: observational study that was conducted at departments of Medicine Rama medical College , Hapur, U.P between January 2021 to August 2022 were selected by using Random Sampling Techniques. 50 patients with type 2 diabetes mellitus attending the out-patient department without any prior history of thyroid disease, were recruited for the study. Thyroid function test was done in all subjects using chemiluminescent immunoassay method. Prevalence of thyroid disorders was Results: found to be signicantly more in females, highest in the age group of 61-70 years, with duration of diabetes mellitus &gt;10 years, and especially in those who had high FBS, PPBS and HbA1c levels signifying poor control of diabetes. There Conclusion: is a positive correlation with the incremental pattern of prevalence of hypothyroidism in patients with diabetes mellitus (30%). Patient who are suffering from diabetes mellitus should be screened for hypothyroidism and treated effectively because it helps in better control of diabetes

Total L-carnitine and insulin resistance in non-obese and obese Iraqi women with polycystic ovary syndrome

Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine illnesses affecting reproductive - age women. L-carnitine has important roles in oxidative stress, energy production and glucose metabolism. It affects insulin resistance as decreased plasma carnitine level has been well reported in type II diabetes mellitus. Hence, it means L-carnitine may reduce insulin resistance which is found in PCO disease. Objective: This study aims to measure the level of L-carnitine and insulin resistance in both obese and non- obese patients with PCOS. Patients and Methods: Sixty women within the reproductive age with PCOS (30 obese and 30 non- obese) were recruited from the Gynecology and Obstetrics Outpatient Clinic in Baghdad Teaching Hospital from June 2016 to June 2017. The data collected for each case included: Height, weight, waist circumference, blood pressure, obstetrical, medical, and medication history as well as ultrasound results. A physical examination was done to evaluate the clinical signs of hyperandrogenism. Biochemical measurements included fasting blood sugar, leutinizing hormone, follicular stimulating hormone, Testosterone and lipid profile were measured together with total L-carnitine (using L-Carnitine Assay Kit Sigma-Aldrich Co.). Insulin resistance was diagnosed according to National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III). PCOS is diagnosed according to the Rotterdam criteria. Results: This study revealed that insulin resistance (IR) was present in 51.7% of PCOS patients, which was higher in obese PCOS patients (73.3%) than in the non-obese (30%). Age of patients, serum cholesterol, LH, and FSH were not related to IR. High mean BMI, waist circumference, FBS and triglyceride were significantly associated with IR (p &lt; 0.05), while low serum HDL and L-Carnitine were associated with IR (p &lt; 0.05). The mean serum total L-carnitine in this study was 34.03μmol/L. Obese women had lower carnitine levels than non-obese women and low serum L-Carnitine was associated with IR. Serum triglyceride, FBS and testosterone were correlated negatively with serum L-carnitine (p &lt; 0.05) and serum HDL correlated positively with serum L-carnitine (p value = 0.001). Conclusions: The mean value of serum total L-carnitine among the non-obese PCOS women was higher than among the obese ones. Low serum L-carnitine is associated with insulin resistance

Analysis on contamination status and dietary exposure assessment of fumonisins in cereal and oil food samples of a coastal city in northern China

Fumonisin is a class 2B carcinogen, which can pollute many food varieties and has been proved to be carcinogenic and teratogenic. 258 pieces cereal and oil food samples were collected from 14 districts in Yantai city from farmers' homes, supermarkets and farmers' markets. The contamination level of fumonisins was detected by High-performance liquid chromatography-tandem mass spectrometry. The pollution level of fumonisin was determined by CODEX STAN 193-1995 and EC No 1881/2006. We conducted quantitative risk assessment of fumonisins through the Daily intake (EDI) and Hazard Quotient (HQ) by point assessment method. Corn and its products were multiple polluted by FBs, and the pollution degree of corn flour and corn-based cake were higher than that of corn kernels. The food exposure risk of FBs in 2-6 years old was higher than that of standard population, urban standard population and rural standard population. The exposure risk of fumonisins in high consumption group was higher than that in general consumption group. The food exposure risk of corn with average content of fumonisins was basically at an acceptable level, but corn and its products with high FBs content caused greater risk for children aged 2-6 years old and adults with high corn consumption.

Diabetes linked oral complications in south Indian cohorts.

Diabetes is characterized by elevated blood sugar and insulin resistance. In poorly controlled or uncontrolled diabetes, persistent hyperglycemia causes oral and systemic problems. Therefore, it is of interest to evaluate biochemical indicators for oral health and diabetes using a fully automatic biochemistry analyzer which separates patient serum from blood samples. Data shows that diabetic oral complex patients showed high RBS, HbA1c, FBS, and PBSS. Thus, dental condition is linked to diabetes.

Impact of Patient-Centered and Self-Care Education on Diabetes Control in a Family Practice Setting in Saudi Arabia.

Background: Diabetes mellitus is a chronic and complex medical disease that leads to significant morbidity and mortality. Patient-centered diabetes education that emphasizes active patient involvement, self, and shared care constitutes a substantial and essential component of the comprehensive diabetes management approach. Objectives: To assess the impact of patient-centered diabetes education sessions on the prescribed treatment plan in controlling diabetes and other related cardiovascular risk factors. Methods: In a pre-experimental pretest-posttest one group study design, all referred patients with type 2 diabetes (T2DM) to the diabetes educator clinic (n = 130 patients) during the period of 6 months from January to July 2021 were subjected to multiple and consecutive patient-centered diabetes education sessions, based on the framework published by the Association of Diabetes Care and Education Specialties (ADCES), in addition to their usual treatment plan. Demographic, social, and biological data were obtained at the baseline, three months, and six months after the intervention. Nonparametric Friedman and Cochran’s Q tests for related samples were applied to examine the impact of this educational intervention on glycosylated hemoglobin (HbA1c) and other associated cardiovascular risks. The results of 130 patients with T2DM showed a significant reduction of mean systolic blood pressure “SBP” (p = 0.015), glycosylated hemoglobin (HbA1c) (p < 0.001), fasting blood sugar “FBS” (p < 0.001), total cholesterol (p < 0.001), low-density lipoprotein (p < 0.001), and triglyceride (p < 0.001), and significant rise of mean high-density lipoprotein (p = 0.011). At three and six months after the intervention, 43% and 58% of patients showed improved HbA1c levels. The mean HbA1c was reduced from 10.2% at the beginning of the study to 8.7% (p < 0.001) after six months. Moreover, a significant reduction in the prevalence of obesity (p = 0.018), high FBS (p = 0.011), and high SBP (p = 0.022) was detected. Conclusions: This study showed a considerable positive impact of diabetes education and patient-centered care on optimizing glycemic and other cardiovascular risk control. The needs of certain patients with T2DM should be addressed individually to achieve the best possible outcomes. Further research is needed to explore the long-term benefits of this intervention.

Presentation And Diagnosis: Pregnancy Induce Diabetes And Hypertension In Medical Doctors At Hospital And Clinics

OBJECTIVES The aim of this study was to assess pregnancy induce diabetes and hypertension in medical doctors. METHODOLOGY This case-control study was conducted after approval by the ethics committee. A total of 72 physicians who were pregnant and diagnosed with pregnancies causing hypertension or diabetes participated in the study. Daily details of hourly blood glucose levels were recorded at the beginning and end of the day. Use SPSS version 24.0 to analyze the results. RESULTS Out of the 33 patients, 23 remained hypertensive at the end of the day, while 10 had normal hypertension at the beginning of the day. Hypotension appeared from the 39th day of which 24 of her ended high, 15 were normal and 10 were diet controlled. The maximum number of pregnancies was 40 in high-care controls and 32 in low-care controls. Out of 30(16) had high FBS at the beginning of the day and 17 of the 42 who had the highest at the end of the day had low FBS. The highest score of 17(42) was presented at the beginning of the day with low FBS and 17 at end of the day with a high ratio and high count of 42. CONCLUSION Health care is important for all patients, whether they are health workers or not. Daily Record helps patients and providers understand patient disease management and take appropriate action.

IDF21-0068 Joint modeling of incident CKD and its association with fasting blood sugar change among diabetic patients

Background: CKD is one of most common microvascular complication of DM and become a major health burden worldwide. Despite the effect of fasting blood sugar on the rate of prevent diabetic kidney disease has a pivotal role on the prevention of the diseases, their association is not well investigated. Therefore, the aim of this study was to assess Incidence and predictors of chronic kidney disease and its association with longitudinal fasting blood sugar change among diabetic patients in Southwest Ethiopia. Aim: To determine incidence and predictors of CKD and modeling its association with FBG change among DM patients in Jimma University medical center, Southwest Ethiopia from 2012 to 2020. Method: A retrospective follow-up study was conducted among type 1 and type 2 DM, Southwest Ethiopia. A total of 437 diabetes patients who newly enrolled in the DM chronic care from 2012 to 2015 were selected using the simple random sampling technique. Selected patients with complete information were followed until February 2020. Data was extracted from patients’ medical records. Cox proportional hazard with linear mixed effect model was jointly modeled using Bayesian approach, and 95% credible interval was used to select significant variables. Model adequacy was checked by residuals plot. Results: A total of 437 DM patients with complete information were followed for 27494.44 PM observation. Overall, 63 patients developed CKD with an incidence rate of 2.29 per1000 PM observation (95% CI: [1.79, 2.93]. FBG was significantly associated with risk of CKD (AHR=4.23, 95% CrI [2.53, 8.23]). Female sex (AHR= 0.51, 95%CrI: [0.27, 0.94]), positive proteinuria (AHR= 2.85, 95%CrI: [1.48, 5.55]), having hypertension (AHR= 2.31, 95%CrI: [1.03, 5.56]) and HDL <40 mg/dl (AHR=3.19, 95% CrI [1.73, 5.98]) were significant predictors of CKD. Discussion: CKD among DM patients continue to be a significant public health problem in Ethiopia. Longitudinal FBG change had significant associations with risk of CKD and high FBS can be used as a signal to screen DM patients for CKD. Female sex, positive proteinuria, hypertension and HDL-C <40mg/dl were significant predictors of chronic kidney disease.

Genotypes of ANKK1 and DRD2 genes and risk of metabolic syndrome and its components: A cross-sectional study on Iranian women

We aimed to investigate the association between polymorphism of DRD2/ANKK1 gene with MetS and its components. Women (n = 531, aged 19–50 years) from the North-west of Iran were included by cluster sampling method. Polymorphisms of ANKK1 and DRD2 genes were defined in the study population. D/D (OR: 3.16; 95%CI: 1.31−7.60) and I/D (OR: 1.76; 95%CI: 1.12−2.78) genotypes of DRD2 (rs1799732) increased risk of MetS compared to I/I genotype. The D/D genotype of DRD2 (rs1799732) increased odds of hypertriglyceridemia in the study population. T/T (OR: 6.72; 95%CI: 1.99−22.71) and C/T (OR: 4.42; 95%CI: 2.79−7.01) genotypes of ANKK1 (rs1800497) increased risk of MetS compared to C/C genotype. Also, C/T genotype increased the odds of HTN, high FBS, high TG and low HDL-C levels compared to C/C genotype. These polymorphisms can affect the MetS components via their relation to the signaling of dopaminergic pathways and eating behaviors.

Thyroid Ultrasound Findings and Its Associated Parameters in Saudi People

Background: Thyroid abnormalities are the most common endocrine abnormalities in Saudi Arabia (KSA). Ultrasonography (USG) is the commonest method of thyroid gland imaging. Thyroid lesions prevalence depends on factors such as sex, age, iodine intake, and other metabolic parameters. Objectives: Investigating different thyroid lesions and their associated clinical parameters. Subjects and Methods: This is a cross-sectional study of adult residents who visited Internal Medicine Clinic in Riyadh, KSA. 206 participants were subjected to thyroid USG, weight and height measurement, laboratory investigations including FBG, HbA1C, ALT, AST, creatinine, uric acid, lipid profile, thyroid stimulating hormone (TSH), and FT4. Results: Thyroid nodules were found in 27.2%, 30.1% had thyroiditis, and 6.8% had pure cysts. There was a significant prevalence of thyroid ultrasound findings within different age groups, (P = 0.002). The highest BMI was found in subjects with nodular size ≤1cm. Subjects with thyroid nodules had higher level of FBG, HbA1c, ALT, AST, uric acid, total cholesterol, HDL-C, LDL-C and TSH. The most frequent thyroid status was euthyroid, followed by subclinical hypothyroidism which had higher frequency in subjects with nodular size ≤1cm (30.8%). Conclusion: Imaging, particularly USG, plays an important role in classifying thyroid gland abnormalities. We found that thyroid lesions, including nodules, pure cysts, and thyroiditis, were non-significantly positively associated with disturbed metabolic profile such as high FBS, HBA1C, ALT, AST, total cholesterol, and LDL levels. Our results for biochemical parameters do not allow inferences on whether they are independent factors associated with thyroid lesions or not.

Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer

Gastric mucosa tumors may present as two distinct major entities: Diffuse and intestinal subtypes. There is no standard treatment for advanced or metastatic gastric cancer. The mevalonate pathway and cholesterol homeostasis are important processes in cancer cells that may be highly relevant in terms of cell growth, survival and metastatic potential. Two model cell lines representing intestinal (NCI-N87) and diffuse (Hs746T) metastatic gastric tumor histological subtypes were treated with different drugs that alter membrane lipid metabolism to determine whether cell proliferation, viability and migration were affected. The results indicated that the cells exhibited significant differences in proliferation when treated with the cholesterol-lowering drug simvastatin, but not with terbinafine, another compound that affects cholesterol synthesis. Only simvastatin affected migration in both cell lines. Reposition studies with mevalonolactone, farnesyl pyrophosphate and geranylgeranyl pyrophosphate in the presence of high and low FBS concentrations indicated that both isoprenoids and cholesterol reversed the antiproliferative effects of simvastatin in gastric cancer cells. The cell lines used in the present study had different sensitivities to several potential anti-neoplastic agents that affect the synthesis of membrane lipids. The diffuse gastric cancer cells were particularly sensitive to simvastatin, suggesting it as an option for combination treatment.

88. Cell stiffness decreases with severity of disc degeneration and inflammatory stimulation

88. Cell stiffness decreases with severity of disc degeneration and inflammatory stimulation

A Study on Prevalence of Metabolic Syndrome in Young Medicos of South Karnataka

Background: It has been calculated that Non Communicable Diseases cause 68% mortality across the world, but mostly in low and middle income countries. Southeast Asia has seen growing NCD deaths since 2000. 60% of total deaths in India in 2012 were attributed to NCDs. International Diabetic Federation (IDF) consisting of experts from various countries and organizations has adopted a definition of Metabolic Syndrome (MetS) which is an aggregation of fatal heart attack risk factors, diabetes and pre-diabetes, abdominal obesity, high cholesterol and high blood pressure. Objectives: To assess the prevalence of Metabolic Syndrome in medical students and determine the behavioral risk factors associated with it. Material and Method: A cross sectional study was conducted on sample of 110 randomly selected medical students of second year MBBS. Sample size calculated keeping the prevalence of metabolic syndrome 21% with precision of 10% and confidence level of 99%. Data was processed using latest SPSS version. Descriptive statistics, chi square, odds ratio and logistic regression were used for statistical analysis. Results: Out of 110 medical students 54 (49.09%) were males and 56 (50.91%) were females. Based on IDF criteria, only 10 (9.09%) had Metabolic Syndrome. The prevalence of individual parameters for Metabolic Syndrome were abdominal obesity (100%), low HDL (60%), High TG 80%, High FBS 50% and raised Blood Pressure 20%. Low intake of fruits was found in 90% and high sugar intake was found among 70% and low level of physical activity was reported in 80% students. Overall risk factors were found in 66% cases. Conclusions: This study concludes that prevalence of metabolic syndrome was 9.09% among young medicos. The prevalence of individual components for metabolic syndrome highest was TG 80%, followed by low HDL then high FBS 50% and raised Blood Pressure 20%. About 66% of young medico showed at least one risk factor for developing Metabolic Syndrome.

Gender Differentials of Metabolic Syndrome in Bangladesh taking Menopause into Consideration

Objective:To assess the gender differences of metabolic syndrome (MetS) in Bangladesh and factors associated with it.Materials and methods: Cross sectional study was performed on 227 premenopausal women, 48 menopausal women and 217 men. The gender differentials were studied with measurement of waist circumference, blood pressure and fasting blood for triglyceride (TG), high density lipoprotein (HDL), blood sugar (FBS).Results:Premenopausal women had 22.9% (95% CI: 17.9-28.8%), menopausal women had 43.8% (95% CI: 30.7-57.7%), and the men had 53.9% (95% CI: 47.3-60.4%) prevalence of MetS giving a 1:1.7:2.1 ratio of premenopausal, menopausal women and men prevalence respectively. More than 95% of study population had low HDL irrespective of gender and menopause status. Obesity was 5.3% in premenopausal women, 14.6% in menopausal women and 54.4% in men. HTN was 10.6% in premenopausal women, 35.4% in menopausal women, and 19.4% in men. High TG was 42.5% in premenopausal women, 41.7%, in menopausal women and 62.0% in men. High FBS was 22.0% in premenopausal women, 37.5% in menopausal women and 30.4% in men.Conclusion: Compared to premenopausal women, MetS in men was two times higher and nearly two times higher in menopausal women, pulling menopausal women prevalence almost equal to men. Menopausal women had high prevalence of HTN while obesity was more prevalent in men. Dyslipidemia should be a concern for the policy makers in search of a prevention program.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 101-107

Prevalence and Associated Factors of Anxiety and Depression Among Patients with Type 2 Diabetes in Kerman, Southern Iran.

PurposeDepression and anxiety are common disorders in patients suffering from type 2 diabetes. These disorders can lead to premature morbidity, exacerbate disease complications, make patients suffer more, and increase health-care costs. As diabetes has increased worldwide recently, it is necessary to reduce the prevalence of factors that are associated with depression and anxiety in diabetes patients. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors, including metabolic components among people with type 2 diabetes.Patients and MethodsWe performed a cross-sectional study in 1500 patients with type 2 diabetes in Kerman, in the southern part of Iran. The prevalence of depression and anxiety was estimated using the Beck Depression Inventory and the Hamilton Anxiety questionnaires, respectively. After calculating the proportions of depression and anxiety, univariate logistic regression was performed. Factors whose P-values were smaller than 0.2 in univariate logistic regression were included in multiple logistic regression for confounder adjustments. The analysis was performed using SPSS version 20.ResultsThe rates of depression and anxiety were 59% (95% CI: 54.48–63.12) and 62% (95% CI: 59.51–66.27), respectively. Factors found to be independently associated with anxiety were high FBS, high LDL-C, high TG, hypertension, complications, low physical activity. Factors found to be independently associated with depression were female gender, older age, high BMI, high FBS, high LDL-C, low HDL-C, high TG, high HbA1c, hypertension, and low physical activity. Complications were independently associated with anxiety but not with depression. Female gender, older age, high BMI, low HDL-C, and high HbA1c were independently associated with depression but not with anxiety.ConclusionCurrent findings demonstrated that a large proportion of patients with type 2 diabetes suffer from depression and anxiety. This study also identified factors associated with these disorders. Controlling some metabolic variables will decrease the prevalence of these disorders and improves clinical remedy and quality of life in patients with type 2 diabetes.

The Correlation Between the Vitamin D Level and Glycemic Control Status Among Diabetic Patients - A Clinical Observational Study

Background: Vitamin D deficiency is widespread and coexisted with diabetes. However, the relation between Vitamin D level and glycemic control is not yet fully understood. This study examines the correlation between vitamin D level and glycemia indicators and diabetic microvascular complications.Methods: The study is a cross-sectional study, had been done at the outpatient department in Najran university hospital, Saudi Arabia from May 2019 to February 2020. 220 patients recruited by simple random sampling.Results: 60% of diabetes (n-130) had been using oral anti-glycemic medications, though most of them had uncontrolled glycemic status and had got microvascular complications. It is notable that among diabetes having a low vitamin D level; 55.5% had high FBS, 45.6% had high RBS and 65% had high HBA1C. Besides,17% have retinopathy, 16.6% have nephropathy, 26.2% have peripheral neuropathy and 1.9% have a diabetic foot.Conclusion: The clinical and laboratory assessments are essential to control the glycemic state in diabetes. The study noted that an inverse relationship between the level of vitamin D with blood sugar levels and diabetic microvascular complications. To assure the feasibility of the prediction of vitamin D level in assessing the progress of diabetes further studies are needed.