High Entropy States Research Articles

Studies of thermophysical properties of high-energy-density states in matter using intense heavy ion beams at the future FAIR accelerator facilities: The HEDgeHOB collaboration

Intense beams of energetic heavy ions are believed to be a very efficient and novel tool to create states of High-Energy-Density (HED) in matter. This paper shows with the help of numerical simulations that the heavy ion beams that will be generated at the future Facility for Antiprotons and Ion Research (FAIR)[W.F. Henning, Nucl. Instr. Meth. B 214, 211 (2004)] will allow one to use two different experimental schemes to study HED states in matter. First scheme named HIHEX (Heavy Ion Heating and EXpansion), will generate high-pressure, high-entropy states in matter by volumetric isochoric heating. The heated material will then be allowed to expand isentropically. Using this scheme, it will be possible to study important regions of the phase diagram that are either difficult to access or are even unaccessible using traditional methods of shock compression. The second scheme would allow one to achieve low-entropy compression of a sample material like hydrogen or water to produce conditions that are believed to exist in the interiors of the giant planets. This scheme is named LAPLAS (LAboratory PLAnetary Sciences).

Unique capabilities of an intense heavy ion beam as a tool for equation-of-state studies

Intense heavy ion beams open new possibilities in high-energy-density matter research. Due to the unique feature of the energy deposition process of heavy ions in dense matter (volume character of heating) it is possible to generate high entropy states in matter without the necessity of shock compression. Previously, such high entropy states could only be achieved by using the most powerful shock wave generators, like nuclear explosions or powerful lasers. In this paper this novel technique of heavy ion heating and expansion is proposed to explore new fascinating regions of the phase diagram, including the liquid phase, the evaporation region with the critical point, and strongly coupled plasmas.

Alcohol interaction with high entropy states of macromolecules: critical temperature hypothesis for anesthesia cutoff

Nerve excitation generates heat and decreases the entropy (review by Ritchie and Keynes (1985) Q. Rev. Biophys. 18, 451–476). The data suggest the existence of at least two thermodynamically identifiable states: resting and excited, with a thermotropic transition between the two. We envision that nerve excitation is a transition between the two states of the excitation machinery consisting of proteins and lipids, rather than the sodium channel protein alone. Presumably, both proteins and lipids change their conformation at excitation. We proposed et al. (1991) Ann. N.Y. Acad. Sci. 625, 315–317) that anesthesia occurs when compounds have a higher affinity to the resting state than to the excited state of excitable membranes, and that there is a critical temperature above with the affinity to the excited state becomes greater than to the resting state. When the temperature exceeds this critical level, compounds lose their anesthetic potency. We used thermotropic phase-transition of macromolecules as a model for the excitation process. Anesthetic alcohols decreased the main transition temperature of dipalmitoypphosphatidyl-choline (DPPC) membranes and also the temperature of the α-helix to β-sheet transition of poly( l-lysine). The affinity of alcohols to the high- and low-temperature states to the DPPC membranes were separately estimated. The difference in the affinity of n-alcohols to the liquid (high-temperature) and solid (low-temperature) states correlated with their anesthetic potency. It is not the total number of bound anesthetic molecules that determines the anesthesia, rather, the difference in the affinity between the higher and lower entropy states determine the effects. The critical temperatures of the long-chain alcohols were found to be lower than those of the short-chain alcohols. Cutoff occurs when the critical temperature of long-chain alcohols is below the physiological temperature, such that the anesthetic potency is not manifested in the experimental temperature range.