Advanced power engineering rely on technological solutions allowing the design, construction and operation of power plants according to the state of the art, extending the limits of available materials for higher cycle efficiencies, for improved reliability and availability of the systems, and assuring in the meanwhile longer service lives. Elevated temperature components, high pressure and high energy sections might be considered relevant with respect to time behaviour of the plant, since load-bearing structural materials are mainly subjected to metallurgical ageing, creep processes due to temperature exposure, thermomechanical and low cycle fatigue induced by load histories, as well as crack initiation and growth. Life improvement objective has to be fully considered and assumes a twofold application: i) at the design and construction stage, with the introduction of new materials and/or adopting better reference data and validated extrapolation procedures; ii) for existing plants, managing proper life extension methodologies integrated with plant rejuvenation, refurbishment or repowering decisions. In the following, attention will be devoted to still open questions which are susceptible to contribute to the goal of safe and reliable, high efficiency thermal power plants, as residual life evaluation in components under multiaxial stress state, on-line plant monitoring, non destructive techniques and expert systems for residual life assessment and in situ repair/treatment techniques.