We study the high-energy fixed-angle Sudakov limit of the scattering amplitudes suppressed by the leading power of the quark mass in perturbative quantum chromodynamics. We prove the factorization and perform all-order resummation of the double-logarithmic radiative corrections which determine the asymptotic behavior of the amplitudes. In contrast to the Sudakov logarithms, the mass-suppressed double-logarithmic corrections are induced by soft quark exchange. The structure of the corrections and the asymptotic behavior of the amplitudes in this case crucially depend on the color flow in a given process and are determined by the eikonal color charge nonconservation. We present explicit results for the Higgs boson production in gluon fusion mediated by a light-quark loop and for the leading power-suppressed contributions to the quark form factors, which reveal "magical" universality. Nontrivial relations between the asymptotic behavior of different amplitudes and the amplitudes in different gauge theories are found.