Recently, a general theoretical description of multihole collimators has been proposed by one of the authors. In this work, the theory was used to study the artifacts, which are caused by the hole-array pattern of high-energy collimators. The relevant outcomes of the study were that the response to a sheet source does not depend on its distance from the collimator, whereas the response depends on the gap between the collimator and the image plane that is located in the scintillation crystal; the dependence of hole-array artifacts on this gap was assessed and the existence of optimal values for which they are minimized was found. A large field of view camera, equipped with a high-energy general purpose collimator for /sup 131/I with hexagonal holes placed in an hexagonal lattice, was used. A series of images of a flood source placed on the external face of the collimator was acquired. Each image was acquired with a different value of the crystal-collimator distance. The analysis of the images clearly showed the existence of optimal crystal-collimator distances to reduce the hole-array artifacts. These distances have been found in agreement with the values predicted by the theory. This work may be useful for the design of new collimators, for the optimal arrangement of camera-collimator system and it may also foster the study of some artifacts compensation methods.