Higher EBL Research Articles

605: Subsequent pregnancy outcome after B-Lynch suture placement

605: Subsequent pregnancy outcome after B-Lynch suture placement

Consultant presence during major obstetric haemorrhage

BackgroundConsultant presence on labour ward can improve patient outcomes, with recommendations for on-site cover of 60 hours/week in units with ≥5,000 births/year. The study aims to assess the potential impact...

1521 LAPAROSCOPIC AND OPEN PARTIAL NEPHRECTOMY: COMPARISON OF COMPLICATIONS USING CLAVIEN GRADING SYSTEM

INTRODUCTION AND OBJECTIVES: To compare postoperative complications in patients who are undergoing laparoscopic partial (LPN) and open partial nephrectomy (OPN) using a standardized complication reporting system. We have also used a scoring system that quantifies the anatomy of renal masses. METHODS: We conducted a retrospective analysis of 189 consecutive patients who had nephrometry scores and underwent elective partial nephrectomy for renal masses by laparoscopic or open technique between January 2000 and December 2009. Demographic, perioperative and complication data were recorded retrospectively. Thirty and 90-day complication rates were compiled and graded using the modified-Clavien complication scale. RESULTS: 107 patients underwent LPN and 82 patients underwent OPN (N 189). OPN patients had higher nephrometry scores compared to the LPN group (7.1 2.4 vs. 5.6 1.8, p 0.001). Surgical and hospitalization times were shorter and EBL was lower in the LPN group (p 0.001). At 30 days, there were more overall complications in the OPN group, whereas there were more major complications (grade 3–5) in the LPN group. However, this did not reach statistical significance. There was no difference in complication rate at 90 days. When subjected to multivariable logistic regression analysis after adjusting for several confounding factors such as age, gender, ASA score, type of partial nephrectomy, nephrometry score, only higher BMI and higher EBL were predictors of more overall complications. CONCLUSIONS: LPN has the advantages of decreased operative time, as well as lower blood loss and a shorter hospital stay. The complication rate in the LPN group is similar to the OPN patients, despite favorable tumor characteristics in LPN patients. Nephrometry score does not predict complications in this limited cohort. Baseline characteristics of patients undergoing laparoscopic and open partial nephrectomy Laparoscopic Open p-value No. patients 107 82

EXCELLENT LONG-TERM ONCOLOGICAL OUTCOME AFTER ELECTIVE TESTIS-SPARING SURGERY FOR LEYDIG CELL TUMORS: A SINGLE-CENTRE EXPERIENCE WITH 19 CASES

When stratifying by highest severity complication, 18% of all P-RPLND patients had only a grade I (i.e. ileus) versus 21% of all PC-RPLND patients (p=NS). PC-RPLND patients had a higher rate of grade II-V complications (16% vs 9%, p=NS). There was 1 mortality due to multiple pulmonary emboli in the PC-RPLND group. CONCLUSIONS: Both P-RPLND and PC-RPLND are associated with low rates of serious morbidity and negligible morbidity in the hands of experienced surgeons. PC-RPLND is associated with longer operative time, higher EBL, a higher rate of overall complications at 37% vs 27% and a higher rate of non-grade I complications.

Spatial clustering of endemic Burkitt's lymphoma in high‐risk regions of Kenya

Endemic Burkitt's lymphoma (eBL), the most common childhood cancer in sub-Saharan Africa, occurs at a high incidence in western Kenya, a region that also experiences holoendemic malaria. Holoendemic malaria has been identified as a co-factor in the etiology of this cancer. We hypothesized that eBL may cluster spatially within this region. Medical records for all eBL cases diagnosed from 1999 through 2004 at Nyanza Provincial General Hospital were reviewed for case residential information to examine this hypothesis. Two cluster detection methods, Anselin's Local Moran test for spatial autocorrelation and a spatial scan test statistic, were applied to this residential data to determine whether statistically significant high- and low-risk areas were present in the Province. During the 6-year study period, 272 children were diagnosed with eBL, with an average annual incidence of 2.15 cases per 100,000 children. Using Empirical Bayes smoothed rates, the Local Moran test identified 1 large multi-centered area of low eBL risk (p-values < 0.01) and 2 significant multi-centered clusters of high eBL risk (p-values < 0.001). The spatial scan detected 3 small independent low-risk areas (p-values < 0.02) and 2 high-risk clusters (p-values = 0.001), both similar in location to those identified from the Local Moran analysis. Significant spatial clustering of elevated eBL risk in high-malaria transmission regions and of reduced incidence where malaria is infrequent suggests that malaria plays a role in the complex eBL etiology, but that additional factors are also likely involved.

6147. A high speed EBL column designed to minimized beam interactions

6147. A high speed EBL column designed to minimized beam interactions

A high speed EBL column designed to minimize beam interactions

The writing strategy and electron optical aspects of the Perkin–Elmer AEBLE 150 EBL system are discussed. For a specific submicron EBL writing task, an ‘‘optimum’’ area for a variable shaped beam is derived. For specific column properties, an optimum gun brightness is chosen to image the shape at maximum beam interactions limited current. The writing system takes advantage of a continuously moving stage to allow a moderate scan field, exploiting in-lens deflection to use a very large aperture angle with a 2 mm field. Experimental data indicates a current density of 100 A/cm2 in rectangular or triangular shapes up to 2 μm in size. Edge resolution is less than 0.15 μm for shapes containing less than 1.5 μA of current. A series of beam profiles taken with a 300 ns exposure cycle shows that the deflection systems will support high speed lithography on insensitive resists.