Watersheds from semiarid regions are more sensitive to hydrological processes and sustainability of water resources than humid regions. Hence, it is indispensable to determine the response of watersheds to hydrological processes for water resource management. Thus, the hydrological response-based watershed prioritization study has been undertaken for eight sub-watersheds from semiarid, basaltic region of Western Ghats of India. Intent to this, a novel index has been parameterized using thematic layers such as drainage density, geology, soil, slope, landform classification, land use/land cover, rainfall and runoff (DGSLR). This study evaluates the performance of DGSLR index using three models, namely analytical hierarchy process (AHP), frequency ratio (FR) and fuzzy logic for sub-watershed-wise prioritization. The FR ratio showed the highest value for very high drainage density (8.73) indicating most probability for a high hydrological response. According to AHP weight, most influencing factors to hydrological processes are precipitation (25%), slope (19%) and land use/land cover (14%) followed by landform classification (11%). These three methods are prioritized study area into four classes, i.e., very high, high, moderate and low using area-weighted average method. These models showed that very high-priority area lies near the outlet of the watershed as well as the upper part of the watershed in high to very high priority in all three models. It covers 33.12% of the total area having a high average slope with high drainage density in sub-watersheds 1, 3, 7 and 8. The predictive capability of DGSLR index was computed by the area under the curve (AUC) and receiver operating characteristic (ROC) method, revealed average accuracy for FR method (AUC = 89%) better than AHP method (AUC = 77%) and fuzzy logic (AUC = 76%). This novel index could be used by the water resources researchers and planners in any terrain to understand the hydrological response.