High Doses Of Gamma Radiation Research Articles

EFFECT OF GAMMA IRRADIATION ON Salvia officinalis L. AND Melissa officinalis L. IN VITRO PLANTS

Salvia officinalis L. (sage) and Melissa officinalis L. (lemon balm) are two valuable medicinal plants from Lamiaceae family. Considering the therapeutic potential of sage and lemon balm extracts, there is currently great interest to increase the production of biological material and the synthesis of bioactive compounds by different methods. Both micropropagation and gamma irradiation represent efficient methods of stimulating the synthesis of bioactive compounds in plants. In order to produce biological material, it is important to establish the doses of gamma radiation that do not have a phytotoxic effect on plants. The aim of the present study was to evaluate the effect of different doses of gamma irradiation (100, 300, and 500 Gy) on sage and lemon balm by quantifying of some biochemical compounds (assimilatory pigments, soluble carbohydrates, and total polyphenols) in in vitro plants. The results obtained revealed that high doses of gamma radiation have phytotoxic effect on in vitro raised plants. However, micropropagation is an efficient method to produce high quality biological material, source for obtaining extracts with therapeutic potential.

Efficacy of iron-silver bimetallic nanoparticles to enhance radiotherapy

Radiotherapy (RT) is one of the primary cancer treatment methods. Radiosensitizers are used to enhance RT and protect healthy tissue. Heavy metals have been studied as radiosensitizers. Thus, iron oxide and iron oxide/silver nanoparticles have been the main subjects of this investigation. A simple honey-based synthesis of iron (IONPs) and iron-silver bimetallic nanoparticles (IO@AgNPs) were prepared followed by characterization with transmission electron microscope (TEM), absorption spectra, vibrating sample magnetometer (VSM), and X-ray diffraction (XRD). Additionally, Ehrlich carcinoma was induced in 30 adult BALB/c mice and divided into 6 groups. Mice of group G1 were not treated with nanoparticles or exposed to irradiation (control group), and group G2 and G3 were treated with IONPs and IO@AgNPs respectively. Mice of group G4 were exposed to a high dose of gamma radiation (HRD) (12 Gy). Groups G5 and G6 were treated with IONPs and IO@AgNPs followed by exposure to a low dose of gamma radiation (LRD) (6 Gy) respectively. The impact of NP on the treatment protocol was evaluated by checking tumor growth, DNA damage, and level of oxidative stress in addition to investigating tumor histopathology. Additional research on the toxicity of this protocol was also evaluated by looking at the liver’s cytotoxicity. When compared to HRD therapy, combination therapy (bimetallic NPs and LRD) significantly increased DNA damage by about 75% while having a stronger efficacy in slowing Ehrlich tumor growth (at the end of treatment protocol) by about 45%. Regarding the biosafety concern, mice treated with combination therapy showed lower alanine aminotransferase (ALT) levels in their liver tissues by about half the value of HRD. IO@AgNPs enhanced the therapeutic effect of low-dose radiation and increased the efficacy of treating Ehrlich tumors with the least amount of harm to normal tissues as compared to high radiation dosage therapy.

Gamma Rays as Modifiers of the Compressive and Flexural Properties of Polyester Polymer Concrete

To improve the mechanical and thermal properties of materials, alternative posttreatments have been proposed. One of these posttreatments is based on the use of ionizing radiation. This work studied the effects of gamma rays on the mechanical and thermal properties of polymer concrete (PC) produced with 80% silica sand and 20% polyester resin. High gamma irradiation doses (100–500 kGy) were used. Mechanical properties (compressive and flexural strength), and thermal properties (thermal conductivity, specific heat, and thermal diffusivity) were analyzed. The results show that the highest values of compressive and flexural strength and elasticity modulus occur when polymer concrete is irradiated at 400 kGy. The compressive strength of the reference concrete was 51 MPa; this resistance increased to 62 MPa (23% higher) when polymer concrete was irradiated at 400 kGy. The modulus of elasticity increased 12%, from 2.17 to 2.44 GPa, whereas the flexural strength increased from 16.2 to 17.7 MPa (9%). Changes in the thermal properties (mainly the specific heat) were obtained at 100 and 200 kGy doses. The results were related to the surface modifications produced in the irradiated polyester resin (analyzed by scanning electron microscopy) and its chemical structure (studied by Fourier-transform infrared and Raman spectroscopies).

Investigating the OSL components and the sensitivity changes in a natural quartz crystal showing an intense post-sensitization TL signal

This study aims to investigate the optically stimulated luminescence of quartz grains exhibiting an intense thermoluminescent signal between 250 and 350°C after sensitization with a high dose of gamma radiation and moderate heat treatments. Pellet discs produced with zeroed and sensitized grains were irradiated with test doses ranging from 0.5 to 40 Gy. After sensitization, the OSL signal of the fast component stimulated with blue light increased more than 1000 times. Annealing at 400°C was adopted to erase the residual signal. The sensitivity changes were assessed after various TL and OSL readings. The annealing cycles were responsible for a significant increase in OSL and a 20% reduction in TL signals. The analysis of the residual TL indicated that the traps responsible for the main components of the sensitized peak (280°C) are harder to bleach than those related to the so-called 110, 325, and 375°C peaks. The sensitivity changes and the relationship between OSL and TL signals were explained in terms of a mechanism of competition involving active and deep electron traps. No correlation was observed between the fast OSL component and the 325°C TL peak.

Low power paper electronics based wearable radiation detector using hybrid halide perovskite (MAPbBr3): A real time monitoring of gamma ray

In this report we demonstrate that a paper based flexible gamma ray detector can be made using hybrid halide perovskite methyl ammonium lead bromide (CH3NH3PbBr3 or MAPB). The wearable paper based detector is solution processed and works at room temperature. It detects gamma ray by a direct method by change of its resistance on exposure to gamma ray and uses IDE (interdigitated electrodes) for boosting current response. This detector grown on a substrate like a paper with large active area, shows a maximum calibrated sensitivity of 5.26 μC Gy−1 cm−2 and a reasonable mobility—life time product () ∼2 × 10−5 cm2 V−1. The detector can be operated in a wide range of gamma photon energy between 100 KeV to 1100 KeV and can detect radiation down to 0.01 μCi activity, which is noise limited. The paper detector shows a good shelf life of more than 6 months and a fast response time of a few seconds. The detector has a high degree of sustenance under exposure to high dose of Gamma radiation and was tested for a cumulative dose of minimum 1.6 KGy. The detector has low power consumption with can operate down to 1 V direct current (DC) bias and with a detector current of ∼1nA. The sensitivity increases with bias and shows saturation beyond 40 V bias. Such a low power flexible gamma detector is expected to have application potential in areas like health care and point of use quick radiation detection.

Effect of gamma irradiation on structural, morphological, optical and thermal properties of Ca doped CuO nanostructure thin films

Semiconductor optoelectronic and photonic devices are used in many harsh environment applications such as space and nuclear reactor etc. Gamma radiation in such environments significantly interacts with the semiconductor materials used in these devices, changing their structural, optical, morphological and thermal properties. Therefore, it is vital to investigate the gamma radiation effect of the material to be exposed to radiation in terms of the performance and lifetime of the application. In this study, nanostructured thin films were produced by doping different ratios (0, 0.3, 1.25, 2.5 and 5 mg/mL) of Ca to the copper oxide (CuO) is a semiconductor used in optoelectronic and photonic devices. The thin films produced were deposited on the glass substrate by the spin coating method. The effects of gamma rays on the structural, morphological, optical and thermal properties of the films were investigated by irradiating with different doses (1, 5, 15, 50, 100 and 150 kGy) used a Cobalt-60 gamma radiation source. The structural, morphological, optical and thermal properties of Ca doped CuO nanostructured thin films were investigated by using X-ray diffractometer (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), atomic force microscope (AFM), mechanical profilometer, UV-Vis spectrophotometry (UV-Vis) and thermogravimetric differential thermal analyzer (TG/DTA). The band gap of thin films were been calculated using Tauc’s plot. The obtained results showed that high-dose gamma radiation caused defects in undoped and Ca doped CuO nanostructured thin films and affected their structural, morphological, thermal and optical properties. Despite the resulting defects, Ca doped CuO nanostructured thin films showed higher absorption intensity and thermal stability against gamma rays. These results showed that Ca doped CuO nanostructured thin films are suitable for many harsh environment applications such as space and nuclear reactors.

Postharvest application of gamma irradiation affects fruit quality and antioxidant enzymes activities of ‘kinnow’ mandarin fruits during cold storage

Food safety with maintained fruit quality is an important challenge for postharvest industry of citrus fruits. The present study was designed to check the effects of gamma irradiation on postharvest fruit quality of ‘Kinnow’ mandarin stored at 5 ± 1 °C and 90 ± 5% Relative Humidity. In the first experiment, fruits were exposed to different doses of gamma radiation (100-500 Gy), while after analyzing the results of first experiment, in the second experiment fruits were treated with 500, 600, 800 and 1000 Gy of gamma radiation. It was observed that higher doses of gamma irradiation exhibited lower weight loss and disease incidence as well as inhibiting the increase of soluble solid content (SSC) and retained higher titratable acidity (TA) and lower SSC: TA ratio. After 90 days of storage, maximum levels ascorbic acid, total phenolic contents and total antioxidants along with catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) activities were recorded higher in fruits treated with 800 Gy. These fruit also exhibited higher score of taste, aroma and texture during storage. Overall results suggest that pre-storage treatment of 800 Gy is the most effective treatment and have potential application for quality management of ‘Kinnow’ mandarin under long term cold storage.

Metal-organic framework nanoparticles as a free radical scavenger improving the stability of epoxy under high dose gamma irradiation

Understanding the degradation mechanism of epoxy resin under irradiation and enhancing the radiation resistance of epoxy resin are of great significance for its application in aerospace and nuclear industries. In this study, we investigated the radiation resistance of epoxy reinforced by UIO-66-OH metal-organic framework. Outstanding radiation resistance was achieved by using UIO-66-OH nanoparticles as radical scavengers to retard epoxy degradation. The introduction of UIO-66-OH reduces the content of free radicals generated after irradiation by 88.17%. UIO-66-OH also improves the mechanical and thermal properties of epoxy before and after irradiation. The scavenging radicals mechanism of hydrogen atom transfer of UIO-66-OH is more dominant than that of graphene oxide and carbon nanotubes. The radiation resistance of UIO-66-OH nanoparticles is related to hydroxyl functionalization and porous structure. This work provides a new idea and method for improving the stability of epoxy resin under gamma ray radiation.

Genetic diversity in gladiolus by using gamma rays

This investigation was carried out to determine the effects of gamma radiation on germination characteristics of gladiolus corms. This experiment was conducted through a factorial design in randomized complete block with three replications. Two factors included cultivars of gladiolus (Red Advance, White Prosperity, Amsterdam, and Rose Supreme) and doses of gamma radiation (0, 15, 25, 35, 45, 55, 65, and 75 Gy). The results showed that corm weight, corm size, and number of daughter corms decreased with increasing radiation doses, however, low dose (15 Gy) stimulated them. High doses of gamma irradiation (75 Gy) showed the lethal effects on various vegetative traits. The low yield at high doses can be due to the reduced vegetative growth as a result of gamma treatments. The results of this study suggest a dose of 40-65 Gy as the optimal dose to improve the vegetative traits of gladiolus.Keywords: Gladiolus, Genetic diversity, Corm, Mutation

Gamma irradiation-induced changes in the structural, optical, electrical and radiation shielding properties of lithium borate glasses

Lithium borate glass with the chemical composition 25Li2O–75B2O3 (LBO) was prepared using the melt quenching technique. The changes in their structural, optical and electrical parameters due to gamma irradiation were investigated and its radiation shielding ability was discussed. The as-prepared glasses were transparent, colourless and inclusion free. The glasses were irradiated for 20, 40, 60, 80 and 100 kGy using a60Co gamma source having a dose rate of 2.906 kGy/h. As the radiation dose increases colour centres were formed in the LBO glass, for higher dosages the glasses turned black. The theoretical structural parameters such as density, optical basicity, ionicity, boron-boron separation, bond density, molar volume and oxygen packing density were calculated. The structural changes were carried out using x-ray diffraction confirming the amorphous nature even after a high dose of gamma irradiation. Gamma irradiation induces the formation of BO4. The bandgap decreases from 3.72 to 3.64 eV with an increase in the dose of gamma irradiation. The dielectric spectroscopy and A.C. conductivity mechanism of the glasses were analyzed. The activation energy of the glasses was calculated before and after gamma irradiation using the Arrhenius plot. High doses of gamma irradiation resulted in an increase in activation energy of LBO glasses which increases from 0.12 eV to 0.42 eV at 100 kHz frequency. The radiation shielding ability of the prepared glass samples was estimated using theoretical simulations by Phy-X/PSD software.

Plastic bottle caps as radiation detectors for high gamma radiation doses

Dosimetric evaluation is indicated for material characterization seeking to identify possible applications; still, proper preprocessing techniques are critical features of this process. This work aimed to determine the linearity response of plastic samples irradiated with gamma rays using the Fourier Transform Infrared (FTIR) measurements. The plastic samples were analyzed using Derivatives and Principal Component Analysis (PCA) methods. They applied linear and Principal Component Regression (PCR) methods to obtain linearity. The methods obtained good results for linearity and also showed the evolution of each technique. In conclusion, the results indicate that the applied methods can be useful in radiation physics and for plastic samples as interesting potential radiation detectors.

Modifications of optical, structural, chemical and morphological properties of molybdenum disulfide (MoS2) sputtered thin films under high dose gamma radiation

Molybdenum disulfide (MoS2) is considered to be a promising member of Transition metal dichalcogenides (TMDCs) displays significant physical and chemical peculiarities that make it promising candidate for extensive applications in nano and micro optoelectronic device applications, energy harvesting and light and gas detection devices. In the present work, we illustrated the influence of gamma ray irradiation on optical, morphological, structural and electronic peculiarities of 2D MoS2 thin films. 2D MoS2 thin films were grown by DC sputtering technique. The synthesized thin films samples were exposed to gamma radiation with 1500 kGy dose. There are significant structural and morphological alterations occur in thin films of MoS2 after exposure to gamma irradiation. From the absorption spectra Urbach energy, indirect optical band gap energy, absorption edge, and extinction coefficient were calculated. Alterations that occur in optical, structural, morphological and electronic parameters after the exposure of gamma irradiation have been corresponding with radiation instigated compositional and structural defects. The peculiarities of virgin and gamma exposed MoS2 thin films with 1500 kGy gamma-ray dose from Co-60 source were studied by UV spectrophotometer, X-ray diffraction (XRD), Rutherford Backscattering Spectroscopy (RBS), X-Ray photoelectron spectroscopy (XPS), Photoluminescence (PL) spectroscopy, Atomic Force Microscopy (AFM), Fourier-transform infrared spectroscopy (FTIR).

Study of the dual biological impacts of aqueous extracts of normal and gamma-irradiated Galleria mellonella larvae

ObjectivesGalleria mellonella assimilates beeswax using many gut enzymes; however, high doses of gamma radiation have been used to eradicate such pests, affecting its life cycle. In vitro studies of irradiated extracts of G. mellonella against bacterial species as well as three tumour cell lines are demonstrated in the present study. The antibacterial and antitumour effects are compared with those of the non-irradiated Galleria mellonella larval extract. MethodsThe effect of different dose levels of gamma irradiation, ranging from 2 to 8 Gy, was tested on G. mellonella lipase, protease, and acid phosphate activities. The antimicrobial activity of un-irradiated and irradiated G. mellonella larval extracts was tested against different gram-positive and gram-negative bacteria and some fungi. The antitumour action was tested against different tumour cell lines. A cytotoxicity assay was performed on normal and irradiated larval extracts against normal human lung fibroblast cells. A microscopic examination of Streptococcus mutants and HepG-2 was performed using transmission and scanning electron microscopy. ResultsOptimum results were obtained at 6 Gy, which enhanced maximum enzymatic activity. Maximum antimicrobial activity was obtained against Streptococcus mutants with MIC 31.25 μg/ml at a dose of 6 Gy. A microscopic examination depicted an apoptotic process for irradiated G. mellonella larvae with either Streptococcus mutants or HepG-2. ConclusionThe present study shows a synergistic relationship between the G. mellonella larval extract and a 6 Gy radiation dose for further biomedical applications.

Modifying Anthocyanins Biosynthesis in Tomato Hairy Roots: A Test Bed for Plant Resistance to Ionizing Radiation and Antioxidant Properties in Space.

Gene expression manipulation of specific metabolic pathways can be used to obtain bioaccumulation of valuable molecules and desired quality traits in plants. A single-gene approach to impact different traits would be greatly desirable in agrospace applications, where several aspects of plant physiology can be affected, influencing growth. In this work, MicroTom hairy root cultures expressing a MYB-like transcription factor that regulates the biosynthesis of anthocyanins in Petunia hybrida (PhAN4), were considered as a testbed for bio-fortified tomato whole plants aimed at agrospace applications. Ectopic expression of PhAN4 promoted biosynthesis of anthocyanins, allowing to profile 5 major derivatives of delphinidin and petunidin together with pelargonidin and malvidin-based anthocyanins, unusual in tomato. Consistent with PhAN4 features, transcriptomic profiling indicated upregulation of genes correlated to anthocyanin biosynthesis. Interestingly, a transcriptome reprogramming oriented to positive regulation of cell response to biotic, abiotic, and redox stimuli was evidenced. PhAN4 hairy root cultures showed the significant capability to counteract reactive oxygen species (ROS) accumulation and protein misfolding upon high-dose gamma irradiation, which is among the most potent pro-oxidant stress that can be encountered in space. These results may have significance in the engineering of whole tomato plants that can benefit space agriculture.

Enhanced thermal properties of sepiolite/poly-3-hydroxyoctanoate nanocomposites as biodegradable packaging materials

In this study, sepiolite was studied as a nanofiller to develop biodegradable packaging materials. Phenyl triethoxy silane (PTES) was grafted onto pristine sepiolite to prepare PTES grafted sepiolite (PSP). The nanocomposites comprising of poly-3-hydoxyoctanoate (PHO) and PSP were fabricated via the melt-blending method and were exposed to different doses (10 and 25 kGy) of gamma irradiation. The scanning electron micrographs of gamma-irradiated nanocomposites demonstrated nice network formation between the polymer matrix and sepiolite nanofibers due to a compatibilizing effect of PTES. The thermal properties of the resulting nanocomposites were enhanced as compared to pure polymer. The gel content of nanocomposites was increased with a high dose of gamma-irradiation. The irradiated nanocomposites buried in soil revealed significant weight loss along with agglomerates formation. Fourier transform infrared analysis of gamma-irradiated nanocomposite sheet buried in soil for three months demonstrated a considerable reduction in the intensities of absorption peaks at 1730 cm-1 (carbonyl stretching), 1385 cm-1 (C-CH3 bending vibration), and 1150 cm-1 (C-O-C linkages). Thus, the gamma-irradiated nanocomposites may be a good substitute for synthetic plastics in food packaging applications.

Pattern of chromosomal aberrations persisting over 30years in a Chernobyl Nuclear Power Plant accident survivor: study using mFISH.

The long-term in vivo cytogenetic effects of high-dose radiation exposure can be traced in accidentally irradiated persons, and particularly useful for developing strategies of monitoring and therapy of such patients, as well as for elucidating the fundamental aspects of hematopoiesis and radiobiology. Using 24-color fluorescent in situ hybridization (mFISH), we analysed the frequency and the spectrum of chromosomal aberrations (CA) in peripheral blood lymphocytes of the Chernobyl Nuclear Power Plant (NPP) accident victim 30, 31, 32 and 33 years after acute accidental exposure to high-dose gamma radiation of the whole body. Totally, 993 metaphase cells were analyzed (or 219, 272, 258, 244 cells each year), of which 297 were aberrant. Our study demonstrated a constant aberrant cell frequency at 28% in 2016–2018 years, while in 2019, a significant increase up to 35% occurred due to contribution of significantly elevated frequency of simple aberrations in the absence of evident recent genotoxic factors. Four clonal aberrations were detected, three of which persisted for more than one year at a frequency up to 2.5% of analyzed cells. The distribution of 731 breakpoints per individual chromosomes was nearly proportional to their physical length, excepting Chromosomes 13 and 20, which were significantly breakpoint-deficient compared to the genome median rate. Monitoring of the long-term effects on chromosomal instability caused by radiation exposure is important for understanding and predicting the long-term effects of ionizing radiation.

Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure

Abstract
 BACKGROUND: Experimental data on the effect of a high dose of gamma radiation 6 Gy on the activity of antioxidant defense enzymes and lipid peroxidation products (LPO) are presented immunocompetent organs in the body of animals in the experiment. It was found that the effect of ionizing radiation led to an increase in the level of diene conjugates (DC) and malondialdehyde (MDA), inhibition of the activity of catalase (CАT) and glutathione peroxidase (GlP), glutathione reductase (GlR) enzymes in almost all the studied objects, as a result of which the development of oxidative stress was observed in them. The results of the study indicate serious changes in the lipid peroxidation and antioxidant system (AOS) under radiation stress. An imbalance of POL-AOS creates prerequisites for the occurrence of immunopathological conditions, contributing to the development of radiation-related tumor infection. pathologies. Violations of functional relationships of the catalytic redox system.
 AIM: The aim of the study was to study the effect of radiation at a dose of 6 Gy on the parameters of lipoperoxidation and the antioxidant system in experimental rats.
 MATERIAL AND METHODS: The work was carried out on 20 male Wistar rats weighing 240 ± 20 g. Experimental animals are divided into two groups: I - normal group; II - group exposed to γ-rays at a dose of 6 Gy.
 RESULTS: After radiation exposure, all objects showed a tendency to increase the product of lipid peroxidation. As is known, the activation of lipid peroxidation is based on excessive generation of reactive oxygen species, which exceeds the physiological capabilities of antioxidant systems that occur after the depletion of enzyme systems.
 CONCLUSION: Based on the results obtained, it was found, that irradiation increases the intensity of the formation of POL products and their accumulation, reduces the activity of enzymes of the antioxidant system in immunocompetent organs in irradiated animals, as a result, the lack of the antioxidant system causes oxidative stress in the body.

Analysis of Gamma Irradiated Potato Genotypes Based on Selected Agronomic Traits

The morphological traits of induced potato plants established from irradiated microtubers with Co60 gamma rays led to the identification of solid mutants with linear leaf shape and various chimerical mutants at the M1V1 stage. Potato breeding requires genetic variation of useful traits for crop improvement. The use of induced mutations is highly effective in enhancing genetic variability. The objectives of the study were to determine dose of mutagen and effects of induced mutation on morphological traits in potato. The study involved potato clones; Kenya Sherekea, Kenya Mpya and Asante (M1V0) improved varieties as parents. Populations of 300 potato mutants were developed by irradiation of microtubers with different dose rates (0, 3, 5, 6, 9, 10, 12, 15, 20 and 30 Gray (Gy)) of gamma rays of Co60 source at Seiberdorf laboratories in Vienna, Austria. The microtubers M1V0, M1V1, M1V2 and M1V3 were established at the University of Eldoret Greenhouse. Data collected on morphology observed was computed using SAS and means separated using Fisher’s protected LSD at 95% significant level. The morphological traits results showed that, there were significant difference in genotypes and dose of mutagen at p≤0.05 for most traits studied. Exposure to higher doses of gamma irradiation (20 and 30 Gy) had significant influence (p≤0.05) on the stem number, number and weight of tubers. This suggest that mutation induction generates genetic variations from which desired mutants may be selected based on the needs and preferences and further assist breeders in developing appropriate breeding strategies to decipher potato production constraints.

The radiophiles of Deinococcaceae family: Resourceful microbes for innovative biotechnological applications

Extremophiles are nature's tiny warriors as they call inhospitable environments their home. They possess special factor(s) that offer an edge over other life forms susceptible to harsh conditions. One such family of extremophiles under discussion here is Deinococcaceae. The microbes belonging to Deinococcaceae are primarily radiophiles, the world's most radiation resistant bacteria, in addition to having resistance to high temperature, metals, cold etc. in specific species. Gamma rays have always been known to be lethal to living cells as it damages DNA, the blueprint of life. But, Deinococci sustain extremely high doses of gamma radiation, about 3000 times more than the dose humans succumb to. This review brings forth the utility of these special factors of Deinococcaceae for a broad range of biotechnological applications.

Dosimetric studies of pure and Ag-doped alumina as nanodosimeter for high gamma radiation doses

This research paper focused on the thermoluminescent (TL) studies of prepared nanomaterials exposed to gamma radiation. The fabricated nanopowder were pure, and silver (Ag) doped aluminum oxide (Al2O3) were produced utilizing the hydrothermal method. The silver dopant was incorporated into the Al2O3 at three different concentrations (0%, 5%, and 10%). The structure and morphological characteristics of nanoparticles were studied using various tools. First, UV–visible spectroscopy confirmed the doping of Ag and determined the optical bandgap. Field emission scanning electron microscopy, transition electron microscopy, and thermogravimetric analysis (FE-SEM, TEM, and TGA) respectively were used successfully to analyze morphology structure and thermal properties of pure and doped fabricated nanopowder. The crystal structure of the products was examined by the x-ray diffraction (XRD) technique and the average crystal size was found 10.6 nm. The dosimetric study of gamma radiation was successfully applied using a different range of higher irradiation doses. The Al2O3 with varied Ag dopant concentrations demonstrated a high potential as a gamma-ray dosimeter in the near future for a variety of applications including medicine and industry.