Background: Generalized anxiety disorder (GAD) is a psychological illness characterized by excessive worry and physical symptoms such as sweating and fast heartbeat. Understanding the prevalence of GAD among university students is crucial for addressing mental health challenges in this population. Objective: This study aimed to determine the prevalence of generalized anxiety disorder among university students in Saudi Arabia and also to assess levels of depression and stress among them. Methods: A systematic review following PRISMA guidelines was conducted. A comprehensive search was performed in major databases using specific keywords related to anxiety, students, and Saudi Arabia. Studies conducted between 2020-2024, in English, and with free accessible articles were included. Data extraction and synthesis were carried out to analyze relevant findings. Results: The systematic search yielded 41 study papers, with 8 meeting eligibility criteria. Various studies reported high levels of anxiety, depression, and stress among university students in Saudi Arabia, with female students showing higher prevalence rates. Factors such as age, gender, and academic performance were associated with increased anxiety and depressive symptoms. Conclusion: The study revealed a high prevalence of generalized anxiety disorder, depression, and stress among university students in Saudi Arabia, emphasizing the need for interventions and support systems. Early detection and management of anxiety disorders are essential for mitigating the economic and social burden associated with these conditions, especially in the context of the COVID-19 pandemic. Addressing mental health challenges among university students is crucial for promoting overall well-being and academic success.