The permeability of the mud cake formed at the formation-wellbore interface is an important factor in the designing of water-based drilling fluids. This study presents a novel approach to utilizing experimental thixotropic and rheological parameters of polymeric water-based drilling fluids having varying concentrations of SiO2 nanoparticles and KCl salt. A fully connected feed-forward multi-layered neural network, more commonly known as a Multilayer Perceptron (MLP) was developed to predict the mud cake permeability using input parameters such as SiO2 & KCl concentration, differential pressure, temperature, mud cake thickness, API LPLT and HPHT filter loss volume and spurt loss volume. The results suggested that the developed Multilayer Perceptron model effectively determined the mud cake permeability based on the input parameters of the WBDF mentioned above. The model converged on the global minima, minimizing the loss function using the Gradient descent algorithm. A higher Coefficient of Determination (R2) value i.e., 0.8781, and a lesser Root Mean Square Error (RMSE) value i.e., 0.04378 indicates the higher accuracy of the model. Pearson’s Coefficient of Correlation obtained via the heatmap indicates that mud cake permeability is strongly influenced by the differential pressure followed by filter loss volume, spurt loss volume, mud cake thickness, and temperature. Previous similar studies have focused on using machine learning algorithms, this study utilized a robust deep learning algorithm i.e., Multilayer Perceptron (MLP) neural network to simultaneously model the combined effects of SiO2 nanoparticles and KCl salt concentrations on mud cake permeability, offering an unprecedented level of accuracy in predicting key WBDF performance parameters