High Barrier Research Articles

Implementation of universal germline testing in underserved patients with young onset gastrointestinal cancer.

10602 Background: Universal germline testing (UGT) in solid cancer patients increases the detection of pathogenic germline variants (PGVs) over guideline-based testing. There is a rising incidence of young onset (YO) gastrointestinal (GI) cancers (50 years and under). PGV rates in this population can be as high as 20%, highlighting the benefit of UGT. Underserved populations experience significant disparities in germline testing. The primary aim of this study is to evaluate rates of germline testing among patients with young onset (YO) GI cancers in a large safety net population and identify barriers and facilitators of testing in order to improve the process. Methods: In this retrospective study, we identified 202 patients ages 18-50 diagnosed with GI cancers between January 2019 and December 2022 at the Lyndon B. Johnson Hospital. Demographic and clinical data were collected and the rate, outcome and process of standard of care germline testing evaluated. Paired T-tests were used to identify factors associated with timeliness and completion of germline. Results: The majority of patients had colorectal (68%) followed by gastro-esophageal cancers (16%). Median age at diagnosis was 42 years. One third were diagnosed with stage IV disease. Half of all patients were recipients of financial assistance based on household income less than 150% of the Federal Poverty Level. Spanish was the primary language spoken by 58% of patients. Among all patients, 148 (73%) were referred to a genetics counselor with germline testing offered in 111 (55%) and completed in 99 (49%). PGVs were identified in 17% of patients tested while variants of uncertain significance were found in 19%. Patients with colon cancer (p<0.001), microsatellite instability on immunohistochemistry (p<0.001), and those with a first-degree relative with cancer (p<0.001) were more likely to complete genetic testing. The average time from initial oncology visit to genetics referral was 20 weeks while that from referral to genetics appointment was 22.5 weeks. The average time from genetics appointment to completion of testing was 14.5 weeks. Patients with private insurance had a significantly shorter time to genetics referral (p<0.05) while English-speakers had a longer time from referral to initial genetics appointment (p 0.019) and to completion of testing (p 0.044). Uninsured patients had significantly lengthier times to test completion (p 0.013). Conclusions: PGVs were detected in 17% of patients with YO GI cancers. Along the genetics services care delivery continuum, patient selection for genetic counselor referral, uptake of genetic testing and timeliness of testing were identified as key barriers to germline testing. Given the high detection rate and barriers to testing identified in this underserved population, we have designed a multilevel intervention aimed at optimizing the implementation of UGT in patients with YO GI cancers.

Tailoring barrier layers design for haute couture through X-ray microanalysis: Insights and guidelines

Barrier layers against intermetallic diffusion are a fundamental part on engineering electroplated coatings as they improve the lifetime of goods reducing wastes and improving the sustainability of the production chain. This study aims to set a cost-effective methodology to characterize barrier systems by evaluating the effectiveness with a recent approach based on XRF and EDS and characterize the kinetic of diffusion processes with X-ray diffractometry. Several high fashion barrier systems were tested highlighting that anticorrosion systems are not automatically suited as barrier layers for intermetallic diffusion, as opposed to industrial practice. Investigations on gold coatings obtained varying the current density revealed a correlation between the activation energy of the diffusion process, roughness, and crystallite size.

Facile production of graphene-based ternary composite coatings on metallic bipolar plates

Graphene-based composite coatings can be applied on metallic bipolar plates (BPs) of PEMFC for corrosion protection and electron conduction, benefited from the high electrical conductivity, chemical stability and physical barrier properties of graphene. To reach the high electrical conductivity requirement, the composite coatings shall have high graphene content, which brings challenges including dispersion, processability and interface compatibility. In this work, polyisocyanate was grafted on graphene surfaces to enhance the compatibility with polyurethane (PU). Carbon black was introduced as conductive bridging, which filled in defects of graphene/PU coatings. The corrosion current density of the ternary composite coatings with 60 % functionalized graphene, 30 % PU and 10 % carbon black was 0.43 μA·cm−2 in H2SO4 solution of pH 3 at 80 °C, while the interfacial contact resistance was 6.75 mΩ·cm2 and the in-plane conductivity was 137.4 S·cm−1. The composite coatings provided an efficient and cost-effective solution for up-scaling production of metallic BPs.

Surface morphology and associated high temperature evolution of copper covered with vapor deposited graphene

Copper (Cu) has been widely used as a conductor in the field of information-transport applications due to its high electrical conductivity. However, it is susceptible to high-temperature surface oxidation. In this work, we examined in detail about the effect of vapor-deposited graphene (Gr) coatings on the high-temperature evolution of Cu surfaces. Both morphology/chemical characterizations and electrical conductivity revealed significantly enhanced resistance to surface evolution, especially at temperatures below 300 °C, for Cu with Gr compared to pure Cu counterparts. Theoretical calculations suggested that the enhanced high-temperature stability of Gr/Cu was mainly attributed to the high energy barrier resistance of defects-containing Gr formation. Moreover, this barrier resistance weakened when the temperature approached 400 °C, leading to the formation of more defect-containing Gr, as confirmed by both quasi-static and statistical results of Raman spectra. The present findings may provide further insights into the surface protective mechanisms of Gr coatings on metals.

Fatigue-resistant adhesion through high energy barriers

The applications of soft materials in various fields often require interfacial adhesion to sustain prolonged static or cyclic loads, whereas most existing adhesives are susceptible to fatigue failure. Unlike in a quasistatic debonding process, which depends more on the average resistance, the key to preventing fatigue crack propagation is to build up high energy barriers locally. Herein, we invoke three types of structural designs to induce large energy barriers at the interface to achieve fatigue-resistant adhesion. By varying the local bending stiffness of the backing layer, locally altering the fracture mode through kirigami patterns, or hindering crack initiation with simple edge notches, we enhanced the fatigue thresholds of various adhesives against peeling by several orders of magnitude, reaching record-breaking values. To verify the proposed mechanism and reveal the details of these remarkable enhancements, we develop theoretical models to study the peeling processes. Based entirely on structural design, the proposed mechanism is non-material-specific and universally applicable to various intermolecular interactions under any harsh environment, such as high temperature, high humidity, and physiological environments. We envision that the strategy and methodologies presented can pave the avenue of future adhesion designs for both durability and reliability.

Cellulose nanocrystal‐modified bio‐based aqueous polyurethane coating agent for kraft paper packaging

AbstractWith the implementation of the “plastic restriction order” and the demand for sustainable society development, biodegradable coatings derived from biomass materials have garnered significant interest. This study presents the synthesis of a double‐salt bio‐based waterborne polyurethane (PLA‐WPU) by utilizing poly(lactic acid) polyol (PLA) and isophorone diisocyanate (IPDI) as the main raw materials, along with 2,2‐dihydroxymethylpropionic acid (DMPA) and sodium ethylenediamine ethanesulfonate (A‐95) as a hydrophilic chain extender. Synergistic reinforcement of PLA‐WPU using hydrophobically modified cellulose nanocrystals (M‐CNC) and polycarbonate diimide (PDCDA). At an M‐CNC content of 3% relative to the effective mass of PLA‐WPU, the tensile strength reached 36.12 MPa. After 8 days a lipase PBS solution, the degradation rate reached 54%. Excellent waterproof performance was observed, exhibiting a contact angle of 143.5°. When applied as a surface coating on kraft paper, the Cobb 60 value decreased from 74.0 to 28.6 g/m2, while increasing the tensile strength by 451.3%. Importantly, the kraft paper maintained excellent waterproofing, mechanical strength, and high barrier properties even after repeated folding, high and low‐temperature conditions, and exposure to varying pH solutions. It proved to be both degradable and recyclable, making it a promising alternative to liner paper or plastic membrane, especially in food packaging.

Studies of carrier transport mechanism in NiO/Ag/NiO transparent conducting electrode/ZnO metal-semiconductor-metal photodetectors

Oxide/metal/oxide multilayers as a transparent conducting electrode (TCE) have been developed to replace metals due to their high transparency and low sheet resistance. Nickel oxide (NiO) film with a high work function was used as an oxide to form NiO/Ag/NiO (NAN) TCE, therefore a high barrier height between NAN/zinc oxide (ZnO) interface. In the study, NAN TCE was deposited on ZnO surface to fabricate metal-semiconductor-metal (MSM) photodetectors (PDs) and study its carrier transport mechanism. The NAN TCE has a low sheet resistance of 6.5 Ω/sq. and transmittance more than 40% in a 300−1000 nm wavelength range. Such issues result in the figure-of-merit is higher (2.3 × 10−4 Ω−1) than that (2.5 × 10−7 Ω−1) of pure single NiO thin film. As compared to the conventional Au/ZnO MSM-PDs, the NAN/ZnO MSM-PDs demonstrates a lower leakage current as a result of Ni atoms diffusing into ZnO and passivating the defects. Due to the high work function of NiO, the NAN/ZnO interface exhibits a barrier height as high as 0.91 eV. The Au/ZnO MSM-PDs reveals only one carrier conduction of ohmic due to the electrons tunnel form Au into ZnO through the surface defects. In contrast, two distinct carrier transport mechanisms were observed in the NAN/ZnO MSM-PDs. At low-voltage for V⩽0.64 V , ohmic conduction dominates and the electrons inject from NAN to ZnO, trapped by the defect states of ZnO. At high-voltage for V⩾0.64 V , the trapped electrons acquire enough energy and emit from trap to conduction band, entering Poole–Frankel emission transport.

Interaction of MRI Contrast Agent [Gd(DOTA)]- with Lipid Membranes: A Molecular Dynamics Study.

Contrast agents are important imaging probes in clinical MRI, allowing the identification of anatomic changes that otherwise would not be possible. Intensive research on the development of new contrast agents is being made to image specific pathological markers or sense local biochemical changes. The most widely used MRI contrast agents are based on gadolinium(III) complexes. Due to their very high charge density, they have low permeability through tight biological barriers such as the blood-brain barrier, hampering their application in the diagnosis of neurological disorders. In this study, we explore the interaction between the widely used contrast agent [Gd(DOTA)]- (Dotarem) and POPC lipid bilayers by means of molecular dynamics simulations. This metal complex is a standard reference where several chemical modifications have been introduced to improve key properties such as bioavailability and targeting. The simulations unveil detailed insights into the agent's interaction with the lipid bilayer, offering perspectives beyond experimental methods. Various properties, including the impact on global and local bilayer properties, were analyzed. As expected, the results indicate a low partition coefficient (KP) and high permeation barrier for this reference compound. Nevertheless, favorable interactions are established with the membrane leading to moderately long residence times. While coordination of one inner-sphere water molecule is maintained for the membrane-associated chelate, the physical-chemical attributes of [Gd(DOTA)]- as a MRI contrast agent are affected. Namely, increases in the rotational correlation times and in the residence time of the inner-sphere water are observed, with the former expected to significantly increase the water proton relaxivity. This work establishes a reference framework for the use of simulations to guide the rational design of new contrast agents with improved relaxivity and bioavailability and for the development of liposome-based formulations for use as imaging probes or theranostic agents.

Structural Engineering of Metal‐Organic Frameworks for Efficient CO2 Reduction Reaction

AbstractMetal‐organic framework (MOF) materials have attracted much attention due to their diverse topological structures, excellent adsorption capacity, and unique physicochemical properties, which hold great promise in catalytic CO2 reduction reaction (CO2RR). However, the original MOFs materials have disadvantages such as poor electrical conductivity, high diffusion barrier and limited accessible catalytic sites, which seriously limit their application in CO2RR. Therefore, many structural engineering strategies have been used to improve the CO2RR performance of the MOFs materials. In this review, we mainly review the four main structure engineering strategies, i. e. crystal engineering, 2D engineering, heterostructure engineering and MOF derivatives engineering, in enhancing the catalytic CO2RR performance of the MOFs. We hope that this review will not only provide insights for the rational design of efficient MOFs materials for the CO2RR, but also stimulate more research work in this field.

On the Passage of a Relativistic Spinless Particle through a Potential Barrier

Contradictory descriptions of the passage of a relativistic particle through a high potential barrier are investigated. The conventional energy-momentum relation yields a real momentum for the particle within the barrier, suggesting classical particle motion. However, this contradicts the law of conservation of energy, which necessitates that the particle's momentum be imaginary, thereby rendering classical motion impossible. This paradox is resolved through the adoption of a novel energy-momentum relation.

Understanding the Liver’s Role in the Clearance of Aβ40

The clearance of peripheral beta amyloid (Aβ) is a potential target for the treatment of Alzheimer’s disease (AD). The liver has been implicated in the elimination of Aβ from the peripheral circulation. Here, the single-pass uptake of Aβ40 in perfused livers from young and old rats (6 to 10 rats per group) was investigated with the multiple indicator dilution technique. Aβ40 had volumes of distribution between those of the vascular marker Evans Blue and the extracellular marker sucrose. The hepatic extraction of Aβ40 was negligible, explained in part by the small permeability surface area products consistent with a high endothelial barrier to liver uptake. There were no substantial effects of age on any of these results. In vitro experiments with isolated hepatocytes and liver sinusoidal endothelial cells showed only very small amounts of Aβ uptake consistent with low intrinsic clearance. These results indicate that the hepatic clearance of Aβ is capacity-limited, explained by the low-permeability surface area products and hepatocyte uptake. However, this does not preclude an effect of aging in longer-term in vivo studies where age-related changes in liver blood flow and protein binding influence liver clearance.

Single-file diffusion and its influence on membrane gas separation: A case study on UTSA-280

Gas permeation in metal-organic framework-based (MOF-based) membranes is often elucidated through the solution-diffusion model, where the adsorption and diffusion of gases play equally vital roles. This study draws attention to a unique phenomenon known as single-file diffusion (SFD) occurring within MOF membranes that possess ultramicropores with dimensions comparable to the gas molecules themselves. When SFD takes place, the separation performance becomes solely reliant on the adsorption quantities on the feed side of the membrane. As a proof of concept, we fabricated a UTSA-280 membrane and subjected it to testing using gas mixtures of CO2/N2 and CO2/CH4. Two crucial observations substantiate the occurrence of single-file diffusion. Firstly, in the gas mixtures, the diffusion coefficients of N2 or CH4 were observed to align closely with that of CO2, despite the intrinsic diffusion coefficients of CO2, N2, and CH4, as determined from single-gas permeation experiments, exhibiting differences. Secondly, the CO2 mole fractions within the adsorption phase closely mirrored those in the gas phase on the permeate side. Given the high adsorption selectivity of UTSA-280 for CO2, the UTSA-280 membrane delivers outstanding permeation selectivity for CO2/N2 (611) and CO2/CH4 (80.7). Our experimental findings are supported by mesoscale kinetic Monte Carlo simulations, which confirmed the relation between the CO2 compositions in the adsorption phase on the feed side and in the gas phase on the permeate side. Furthermore, density functional theory calculations revealed high energy barriers associated with CO2 surpassing its counterparts, rendering such processes unfavorable, thereby reinforcing our experimental findings regarding single-file diffusion.

Cysteine Radical and Glutamate Collaboratively Enable C-H Bond Activation and C-N Bond Cleavage in a Glycyl Radical Enzyme HplG.

Hydroxyprolines are abundant in nature and widely utilized by many living organisms. Isomerization of trans-4-hydroxy-d-proline (t4D-HP) to generate 2-amino-4-ketopentanoate has been found to need a glycyl radical enzyme HplG, which catalyzes the cleavage of the C-N bond, while dehydration of trans-4-hydroxy-l-proline involves a homologous enzyme of HplG. Herein, molecular dynamics simulations and quantum mechanics/molecular mechanics (QM/MM) calculations are employed to understand the reaction mechanism of HplG. Two possible reaction pathways of HplG have been explored to decipher the origin of its chemoselectivity. The QM/MM calculations reveal that the isomerization proceeds via an initial hydrogen shift from the Cγ site of t4D-HP to a catalytic cysteine radical, followed by cleavage of the Cδ-N bond in t4D-HP to form a radical intermediate that captures a hydrogen atom from the cysteine. Activation of the Cδ-H bond in t4D-HP to bring about dehydration of t4D-HP possesses an extremely high energy barrier, thus rendering the dehydration pathway implausible in HplG. On the basis of the current calculations, conserved residue Glu429 plays a pivotal role in the isomerization pathway: the hydrogen bonding between it and t4D-HP weakens the hydroxyalkyl Cγ-Hγ bond, and it acts as a proton acceptor to trigger the cleavage of the C-N bond in t4D-HP. Our current QM/MM calculations rationalize the origin of the experimentally observed chemoselectivity of HplG and propose an H-bond-assisted bond activation strategy in radical-containing enzymes. These findings have general implications on radical-mediated enzymatic catalysis and expand our understanding of how nature wisely and selectively activates the C-H bond to modulate catalytic selectivity.

Photocatalytic C(sp3)‐H gem‐Difluoroallylation and Alkylation with Alkenes via a Base‐Assisted Formal 1,2‐Hydrogen Atom Transfer of Amidyl Radicals

Comprehensive SummaryCompared to well‐established 1,5‐HAT of N‐centered radicals, the synthetic applications of 1,2‐HAT process were scarce due to the high barrier and constrained three‐membered transition state. Here, we have developed a novel C(sp3)‐H gem‐difluoroallylation via a base assisted formal 1,2‐HAT of amidyl radicals with the reductive quenching cycle of photocatalyst. This transformation enables the efficient formation of α‐aminoalkyl radicals via 1,2‐HAT and showcases good functional group tolerance. Our preliminary mechanistic experiments, along with Density Functional Theory (DFT) calculations demonstrate the feasibility of 1,2‐HAT of amidyl radicals, especially when assisted by a base. Furthermore, our method also succeeds in the Giese addition of electron‐deficient alkenes as well as styrene.

Experiment evaluation and thermodynamic analysis of pulping modification on ordered conversion of bark in supercritical water

Major obstacles of supercritical water gasification (SCWG) of lignocellulosic biomass, including ineffective pulping for energy self-sufficiency and a high conversion barrier significantly inhibited its large-scale development. In this study, the pulping effect of alkaline and salt pulping for high concentration bark slurry were compared systematically. The SCWG performances of bark (non-catalytic/catalytic) and bark slurry were evaluated. Based on energy self-sufficiency, a novel SCWG process of 50 wt% bark slurry was designated with a multistage reactor configuration and pulping process. The findings suggest that alkaline pulping had a wider applicability (reaching 50 wt%) and better rheological properties than salt pulping. Only 30 wt% bark slurry was capable for applying salt pulping because of solid residue with the excessive salt addition. Alkaline pulping resulted in an ordered conversion of 5 wt% and 10 wt% bark slurries during SCWG, with complete gasification of 5 wt% bark slurries prepared by KOH and NaOH at 650 and 680 °C, respectively. Besides, alkaline and salt pulping reduced the 26 % and 33 % carbon emissions, respectively. In the novel process, the optimal ratio of preheated water to bark slurry was 4 (water diversion to the primary and secondary gasification reactors of 1:3), which exhibits in energy and exergy efficiencies of 47.47 % and 48.63 %, respectively. This configuration reduces exergy losses in the gasification reactor and heat exchanger, aiding in the large-scale industrial output of SCWG.

Genetic differentiation of wild boar populations in a region affected by African swine fever

In the European Union, African swine fever (ASF) affects wild boar (Sus scrofa) populations in several Member States. Knowledge of population connectivity is important for the implementation of control measures, in particular the establishment of effective barriers. Population genetic comparisons of neighbouring populations can be very helpful in this respect. The present study investigated the genetic differentiation of wild boar in eastern Germany. This region has been affected by ASF since September 2020. A total of 1,262 wild boars from 31 hunting grounds (populations) in ASF-affected and ASF-free districts were sampled over a total area of almost 100,000 km². The study area encompassed a network of geographical factors that promote (roads, rivers, cities) or inhibit (natural areas, habitat corridors) genetic differentiation between wild boar populations. The genetic differentiation of the areas was based on 12 microsatellite markers. Three different Bayesian algorithms were used to analyse the data. The results were combined into a common approach with 9 clusters. Based on the cluster distribution in each population, the connectivity between the areas was quantified. The strongest differentiation was found along an imaginary line along the lower Elbe valley through Berlin and the A11 freeway to the Szczecin Lagoon. In contrast, the Mecklenburg Lake District and the south-east of the study area showed strong connectivity between areas. The special features of the landscapes along the lower Elbe valley, which was assessed as highly connective, and the high barrier effect of the A11 freeway in contrast to the other freeways in the study area show that barrier effects cannot be generalised in principle, but are actually determined by the circumstances of individual structures. The results of the connectivity analysis were compared with the distribution of viral lineages and variants. The genotypes of the wild boar populations and the ASFV lineages and variants showed a good explanatory approach for the observed disease dynamics in the study area. The newly gained knowledge on barriers and regionally different connectivity between wild boar populations can support considerations and measures for the containment of ASF in the affected areas by improving the understanding of wild boar dispersal dynamics.

CVD graphene contacts for lateral heterostructure MoS2 field effect transistors

Intensive research has been carried out on two-dimensional materials, in particular molybdenum disulfide, towards high-performance field effect transistors for integrated circuits1. Fabricating transistors with ohmic contacts is a challenging task due to the formation of a high Schottky barrier that severely limits the performance of the transistors for real-world applications. Graphene-based heterostructures can be used in addition to, or as a substitute for unsuitable metals. In this paper, we present lateral heterostructure transistors made of scalable chemical vapor-deposited molybdenum disulfide and chemical vapor-deposited graphene achieving a low contact resistances of about 9 kΩ·µm and high on/off current ratios of 108. Furthermore, we also present a theoretical model calibrated on our experiments showing further potential for scaling transistors and contact areas into the few nanometers range and the possibility of a substantial performance enhancement by means of layer optimizations that would make transistors promising for use in future logic integrated circuits.

Solar-Driven Conversion of CO2 to C2 Products by the 3d Transition Metal Intercalates of Layered Lead Iodides.

Photocatalytic CO2 reduction to high-value-added C2+ products presents significant challenges, which is attributed to the slow kinetics of multi-e- CO2 photoreduction and the high thermodynamic barrier for C-C coupling. Incorporating redox-active Co2+/Ni2+ cations into lead halide photocatalysts has high potentials to improve carrier transport and introduce charge polarized bimetallic sites, addressing the kinetic and thermodynamic issues, respectively. In this study, a coordination-driven synthetic strategy is developed to introduce 3d transition metals into the interlamellar region of layered organolead iodides with atomic precision. The resultant bimetallic halide hybrids exhibit selective photoreduction of CO2 to C2H5OH using H2O vapor at the evolution rates of 24.9-31.4µmol g-1h-1 and high selectivity of 89.5-93.6%, while pristine layered lead iodide yields only C1 products. Band structure calculations and photoluminescence studies indicate that the interlayer Co2+/Ni2+ species greatly contribute to the frontier orbitals and enhance exciton dissociation into free carriers, facilitating carrier transport between adjacent lead iodide layers. In addition, Bader charge distribution calculations and in situ experimental spectroscopic studies reveal that the asymmetric Ni-O-Pb bimetallic catalytic sites exhibit intrinsic charge polarization, promoting C-C coupling and leading to the formation of the key *OC-CHO intermediate.

Development of high barrier poly(l-actic acid)/chitosan/graphene oxide flexible films for meat packaging by layer-by-layer

An new high-barrier packaging films for meat preservation were obtained by depositing graphene oxide (GO) layer-by-layer (LbL) on poly(l-lactic acid)(PLLA)-poly (butylene itaconate) (PBI) copolymers (PLBI) with chitosan (CS) as bonding layer in this study. The 1H NMR results revealed that PLBI copolymer was successful synthesized. The introduction of PBI reduced the Tg and crystallization capacity of PLLA film, which made the copolymer films exhibit extremely high flexibility (up to 186.1% elongation at break). The film also exhibited high hydrophilicity, which was favorable for the effective attachment of CS. With CS as an intermediate layer, the FTIR and SEM results showed that the GO was evenly distributed onto the PLBI film surface due to the electrostatic interaction. The oxygen, water vapor and UV light barrier properties of PLBI/CS/(GO-CS)x films were improved and increased with the GO-CS layers. The PLBI/CS/(GO-CS)10 films, with extremely low oxygen permeability coefficients about 0.4 × 10−8 cm3 m/m2·h·Pa, delayed the increase in weight loss, hardness, pH, TVB-N, TBARS, and total viable counts of chilled meat during storage. It also decreased the discoloration, and loss of springness and cohesiveness of chilled meat caused by long-term refrigeration. The LbL films even showed better freshness-keeping effect than commercial PA/PE films due to its superior barrier and certain antibacterial properties, suggesting great potential application in fresh meat preservation.

High barrier polyesters based on 2,5-furandicarboxylic acid and disulfide bond: Smart degradation induced by low concentrations of redox reagent

Bio-based and biodegradable polymers opens up opportunities to overcome resource depletion and plastic pollution. However, the degradation mechanism based on ester bond breakage makes it difficult to achieve controllable degradation induced by external stimuli. In this work, we present a new 2,5-furandicarboxylic acid-based copolyesters (PBFDi) by partially replacing carbon–carbon backbones with disulfide bonds and discuss the influence of disulfide bonds on thermal stability, crystallization behavior, mechanical and barrier properties of polyesters. They could maintain stable for 1 h at processing temperatures of 220 °C, meeting the needs of long-term melt processing. The asymmetric structure of the furan ring and the slower free rotation of disulfide bonds help restrict the mobility of chains and obstruct gas permeation, resulting in 9.3–126.7 times increase in O2 barrier than commercial PBAT. With the introduction of small amount (≤40 %) of disulfide bond units, the hydrolysis rate is relatively slow and can maintain stable during storage and use. As expected, the copolyesters show redox dual-responsive degradation. Even at low concentrations (0.01 M and 0.1 M) of H2O2, the transition from hydrophobicity to hydrophilicity can be achieved, expected to accelerate the hydrolysis of PBFDi. The fast cleavage of disulfide bonds induced by DTT could be influenced by the copolymerized FDCA units. Lastly, the redox dual-responsive mechanism is elucidated, and how the rigid FDCA co-monomers affect the redox dual responsiveness is also clarified.