Hidden Threats Research Articles

Hidden threats: Chemotherapy-related clonal hematopoiesis in patients with ovarian cancer

Hidden threats: Chemotherapy-related clonal hematopoiesis in patients with ovarian cancer

From Detection to Prediction: AI-powered SIEM for Proactive Threat Hunting and Risk Mitigation

The evolution of cybersecurity has witnessed a transformative shift from reactive defense measures to proactive threat-hunting and risk-mitigation strategies. In response to the rapidly evolving threat landscape, the integration of Artificial Intelligence (AI) into Security Information and Event Management (SIEM) tools has emerged as a crucial solution. Historically, SIEMs primarily aggregated security data but struggled to analyze the vast, complex datasets effectively. The integration of AI, especially Machine Learning (ML) and Deep Learning (DL), revolutionized these systems. AI algorithms enable SIEMs to extract meaningful insights from massive datasets, allowing for the identification of subtle anomalies and hidden threats that may not be detected by traditional detection methods. This transition marks a fundamental shift from simple data aggregation to intelligent analysis, empowering SIEMs to move beyond detection towardproactive threat hunting. This paper highlights the role of AI in predicting threats, leveraging historical data to forecast potential risks, and continuously learning to adapt to evolving threat landscapes. It also explores the real-world use cases of AI-powered SIEMs in proactive threat hunting and risk mitigation.

Hidden Threats: Heavy Metals and the Cognitive Challenges of Specific Learning Disorders

Hidden Threats: Heavy Metals and the Cognitive Challenges of Specific Learning Disorders

Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges.

The use of glucagon-like peptide-1 (GLP-1) receptor-based multi-agonists in the treatment of type 2 diabetes and obesity holds great promise for improving glycaemic control and weight management. Unimolecular dual and triple agonists targeting multiple gut hormone-related pathways are currently in clinical trials, with recent evidence supporting their efficacy. However, significant knowledge gaps remain regarding the biological mechanisms and potential adverse effects associated with these multi-target agents. The mechanisms underlying the therapeutic efficacy of GLP-1 receptor-based multi-agonists remain somewhat mysterious, and hidden threats may be associated with the use of gut hormone-based polyagonists. In this review, we provide a critical analysis of the benefits and risks associated with the use of these new drugs in the management of obesity and diabetes, while also exploring new potential applications of GLP-1-based pharmacology beyond the field of metabolic disease.

Influence of the COVID-19 pandemic on the transition of people on the Polish labor market – hidden threats

Abstract The article analyzes changes on the Polish labor market after the outbreak of the COVID-19 pandemic. It aims to assess the effect of the SARS-CoV-2 pandemic on the transition of people on the labor market in Poland. The decided majority of research into the effects of the COVID-19 pandemic on the labor market was based exclusively on resource analysis, omitting stream analysis. This research fills this gap and provides analysis by quarter of the transition of people on the labor market between employment, unemployment, and professional inactivity. The COVID-19 pandemic caused a severe drop in the number of people in work in the second quarter of 2020, similar in level to an analogous increase in the number of people professionally inactive. The effects of the pandemic were much more severe for women than for men. Detailed analysis of transitions on the labor market shows that around 50% of jobs lost due to the outbreak of the pandemic were not regained. Many redundancies were permanent, which may translate into a weakening of the dynamic for the recovery of the labor market in the future.

Dealing with Hidden Threats: The Antimicrobial Effect of the Embalming Process.

Individuals naturally carry bacteria and other microbes as part of their natural flora, with some being opportunistic pathogens. Approximately 30% of the population is known to carry Staphylococcus aureus in their nasal cavity, an organism that causes infections ranging from soft tissue abscesses to toxic shock syndrome. This problem is compounded by the presence of antibiotic-resistant strains such as Methicillin-Resistant Staphylococcus aureus (MRSA). Commensal bacteria present on cadavers pose a risk to those who handle the body. As a Medical School Anatomy laboratory that performs hands-on cadaveric dissection, we wanted to know whether the embalming process is sufficient to kill all commensal bacteria that pose a risk to staff and students. Even if these strains do not cause disease in these individuals, secondary transmission could occur to friends and family, who may be at higher risk of acquiring an infection. Embalming is assumed to eliminate all microbial contamination on the body. However, there are limited studies to confirm this. This study characterises the incidence of antibiotic sensitive and resistant bacteria in cadavers donated for medical teaching and research. We have screened for Methicillin-Resistant Organisms (MRO) and Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria. In this study group of cadavers, approximately 46% (16/35) carry an MRO, while 51% (18/35) carry an ESBL positive organism prior to embalming. By determining the organisms' presence pre- and post-embalming, we can evaluate the embalming procedure's effectiveness. Our results show embalming eliminates detectable microbes in about 51% (18/35) of the cadavers. MRO dropped by 75% (16 to 4 positive cadavers), while ESBL organisms went down by almost 95% (from 18 to 1 positive cadaver). There was a further decrease in the number of positive cadavers after storage at 4 °C to 6% (2/32). Thus, although the embalming process does not immediately sterilise all the cadavers, prolonged storage at 4 °C can further reduce the number of viable bacteria.

Hidden Threats and Overlooked Solutions: Unnoticed Risks and Firm Action in Latin America

Work on institutional distance has documented a number of challenges that multinational corporations face when they begin operations in distant countries. Although it has also focused principally on how socio-political risks generated by the difficulties can be mitigated by political ties, the manners in which local firms address these problems has been overlooked. At the same time, scholars in this field have not fully documented the array of socio-political challenges firms face. The field of international business needs theories that go beyond those based on new institutional economics to discover new sources of risk and how they are mitigated. I argue that the varieties of capitalism approach provides the proper framework for undertaking this type of work. I use this approach to examine how an Argentine multilatina developed a network organizational structure that effectively mitigated these risks in inter-firm relations and finance in Argentina and failed to mitigate such risks in the areas of inter-firm relations and employee relations in Brazil. I also coin the term indigenous assets to describe the type of knowledge MNEs need to acquire before entering new countries. This article concludes by explaining the relevance of its findings for theory and praxis.

EP285: Hidden threats: Identifying genetic risks for cardiomyopathy complications in healthy pregnant women

Peripartum and pregnancy-associated cardiomyopathies (PPCM/PACM) refer to cardiac dysfunction and failure with onset during or immediately following pregnancy. PPCM patients are most often without a previously identified cardiac diagnosis but are at risk of long-term and significant functional compromise. Studies suggest that 10-15% of PPCM cases were familial and mainly involved genes identical to those associated with dilated cardiomyopathy (DCM) unrelated to pregnancy.

Sabotage, Online Gossip, and Hidden Threats: How the Protest Against Coronavirus Measures is Politized in Russia

Рассматривается феномен дискурсивного сопротивления российской государственной политике вакцинации со стороны граждан, объединившихся на этой почве в неформальные группы и сформировавших политический протестный дискурс в социальных медиа.

Covert Channel Detection: Machine Learning Approaches

The advanced development of computer networks and communication technologies has made covert communications easier to construct, faster, undetectable and more secure than ever. A covert channel is a path through which secret messages can be leaked by violating a system security policy. The detection of such dangerous, unwatchable, and hidden threats is still one of the most challenging aspects. This threat exploits methods that are not dedicated to communication purposes, meaning that traditional security measures fail to detect its existence. This review has introduced a brief introduction of covert channel definitions, types and developments, with a particular focus on detection techniques using machine learning (ML) approaches. It provides a thorough review of the most common covert channels and ML techniques that are used to counter them, as well as addressing their achievements and limitations. In addition, this paper introduces a comparative experimental study for some common ML approaches that are commonly used in this field. Accordingly, the performance of these classifiers was evaluated and reported. The paper concludes that our information is still at risk, nothing is said to be secured and more work on the detection of covert channels is required.

Inaugural Issue ofEJPOResponds to the Covid-19 Crisis

Inaugural Issue of<i>EJPO</i>Responds to the Covid-19 Crisis

Justice in the Digital Age: Technological Solutions, Hidden Threats and Enticing Opportunities

This article focuses on and weighs the main benefits and risks of introducing and deploying technological instruments for justice, as well as their potential effect on fairness. The replacement with and complementary use of technological solutions in light of their application in the judicial system in the digital age are considered. The explicit and implicit risks that arise from the introduction and deployment of technology instruments are analysed. Taking an axiological approach that assumes the a priori value of human rights, justice, and the rule of law, we evaluate the main dangers that the use of technological solutions in the justice system entails. With the help of formal legal and comparative legal methods, as well as the analysis of scientific literature and contextual analysis of open sources on the capabilities of artificial intelligence and the bias of algorithms, the article fills in the gaps regarding the potential of technology to improve access to justice and the use of algorithms in decision-making. It is noted that some technological solutions, as well as the usual behaviour of all actors in the digital era, change the nature of interactions, including those in the justice system. The question of the possibility of algorithmic justice is considered from the standpoint of fairness and non-discrimination. The article shows how the use of algorithms can improve procedural fairness but emphasises a careful and balanced approach to other elements of fairness.

Recovery from hemorrhoids and anal fissure without surgery.

An anal fissure (AF) is a linear tear in the distal anal canal and is one of the most common causes of anal pain. Hemorrhoidal disease (HD) is a symptomatic growth and distal displacement of normal anal cushions. Numerous studies have addressed the contributing factors of these conditions, yet the results remain controversial. In this study, we hypothesize that increasing patients' awareness of hidden risk factors could reduce the rate of HD and AF. A questionnaire-based controlled study was planned. After power analysis, patients with HD (n=60) and AF (n=60) were enrolled consecutively into the study group and compared with the control group (n=60) of healthy individuals. The survey was designed to assess the participants' toilet and dietary habits and anxiety risk. Odds ratios were calculated and a binary logistic regression model was constructed to identify associated factors. Hard stools, spending more than 5 minutes in the toilet, frequent straining during defecation, and increased spice intake were more frequent in the patients with HD; and hard fecal consistency, time elapsed in toilet greater than 5 min, straining during defecation, and high anxiety risk were more frequent in the patients with AF as compared to the control group (p<0.05). Possible associations were identified between habitual factors or conditions (i.e., fecal consistency, the time elapsed in the toilet, straining during defecation) and anxiety and benign anorectal diseases (i.e., HD and AF). Patients should be advised about these hidden threats.

Potential of deconcentration of attention methods for use in the information society

This paper is devoted to the results of our issues exploration increasing efficiency action in extreme circumstances. Long time we study only combat oriented activities but now it is obvious that work with information torrents has the same features of stress as a fight. Our exploration was based on Oleg Bakhtiyarov ideas who study deconcentration of attention phenomenon. We adapted these ideas and combined traditional for our country approaches to hand-to-hand combat and special software. We used two main ideas for experiments. The first one was searching for hidden threats and stealthy attacks with deconcentration and after that was concentration attention on threats and destroying them. This gave us only part-time at deconcentration. We used “plane deconcentration” for searching and “multidimensional deconcentration” for action. The second idea was about using deconcentration for avoiding dangerous situations. That case was about full-time deconcentration. We discovered two types of usage deconcentration indirect or without direct contact with attackers but not only this feature and we need to explore it in the future. We discovered the same features in combat activities and works with information torrents. In addition, the same features were discovered between our data and the other from e-sports. In addition, the same features were discovered between our data and the other from e-sports. All of that gives us opportunities to use the deconcentration of attention methods for tasks that are needed for operators and common people in the information society (searching, detection, distinguishing, and filtration of information torrent) and, of course, for mental hygiene goals.

The security dimension of Ukrainian-Russian relations around Crimea in the political activity of the People’s Movement of Ukraine in 1991–2008th.

In this general article withsecurity dimension of Ukrainian-Russian relations around Crimea in the political activity of the People’s Movement of Ukraineis discussed. The key political statements of the PMU concerning the Crimea and Sevastopol military base of the Black Sea Fleet of the Russian Federation were investigated. An assessment of the position of political force on Russian policy in the Crimea is given. It was found out that in their activity, the members of the PMU paid constant attention to the lack of a clear state policy of the Ukrainian authorities regarding the Crimea and the military contingent located on the peninsula of the Russian Federation. In most cases, the PMU pointed out that the lack of well thought-out Ukrainian policy in the Crimea along with the activity of Russia itself is a catalyst for destabilizing events on the peninsula. Particular attention of the «Rukhvtsy» paid attention to the activity of various cultural and educational groups in the Crimea, which were completely loyal to Russia. In addition, the special emphasis in the article is made in the position of the PMU on the base of the Black Sea Fleet of the Russian Federation. It was found out that in the vision of political power, the presence of the Black Sea Fleet of Russia in the Crimea was destabilizing not only on the socio-political situation in the Crimea, but also throughout the territory of Ukraine. At the same time, «Rukhvtsy» indicated that the lack of well-thought Ukrainian policy in bilateral relations around Crimea could further develop into a full-scale conflict. The main proposals of the PMU concerning the possible regulation of tension in bilateral relations are outlined. It is concluded that in 1991–2008 the People’s Movement of Ukraine as a political force was clearly aware of the hidden threats to national security contained in the Ukrainian-Russian relations around Crimea. At the same time, in spite of numerous political statements and appeals to the top government of the state, the proposals voiced by the PMU did not take into account in any way that in the future they became a catalyst for the beginning of Russian open aggression against Ukraine.

Chemical hazards in construction industry

Rapid technological progress in construction requires that more and more attention should be paid to human security issues. Threats occur both at the stage of building facilities and during their use. Some impacts are easy to identify during construction stage like shocks and vibrations, others are hidden from sight and direct sensing like the harmful effect of chemicals. In addition to accidents that happen on construction sites, there are still objective threats, which may occur throughout the lifetime of the facility. In addition to clearly perceptible ones such as earthquakes, hurricanes, fires, there are hidden threats as well: bacteriological contamination, radiation or chemical interactions that occur in time. This article points to the most common chemical hazards. Examples of chemical threats occurring in construction at the stages of design, construction and use of buildings will be given below.

ИНТЕРНЕТ ВЕЩЕЙ КАК СИСТЕМНЫЙ ФАКТОР ИНТЕГРАЦИИ ФИЗИЧЕСКОЙ, ЦИФРОВОЙ И ВИРТУАЛЬНОЙ СРЕД ОБИТАНИЯ ЧЕЛОВЕКА

The article analyses the role of the Internet of Things as an integrator of techno-physico-biological changes in human environment. The grounds for the definition of a “smart” thing are specified, and the field of the meanings of the notion “thing” in the information society is identified. Particular attention is drawn to the system of direct benefits and hidden threats, generated by the Internet of Things in the aspect of changing the parameters of human life, mentality, identification, and socialization. In the author’s opinion, the philosophical research of the Internet of Things has the potential for substantiating the criteria of the relationship between a human being and things, traditional and “smart”, as well as the conditions and opportunities for human advancement in the environment of the Internet of Things.

Fumigating the Hygienic Model City: Bubonic Plague and the Sulfurozador in Early-Twentieth-Century Buenos Aires.

The 1899/1900 arrival of bubonic plague in Argentina had thrown the model status of Buenos Aires as a hygienic city into crisis. Where the idea of foreign threats and imported epidemics had dominated the thinking of Argentina's sanitarians at that time, plague renewed concerns about hidden threats within the fabric of the capital's dense environment; concerns that led to new sanitary measures and unprecedented rat-campaigns supported by the large-scale application of sulphur dioxide. The article tells the story of early twentieth-century urban sanitation in Buenos Aires through the lens of a new industrial disinfection apparatus. The Aparato Marot, also known as Sulfurozador was acquired and integrated in the capital's sanitary administration by the epidemiologist José Penna in 1906 to materialise two key lessons learned from plague. First, the machine was supposed to translate the successful disinfection practices of global maritime sanitation into urban epidemic control in Argentina. Second, the machine's design enabled public health authorities to reinvigorate a traditional hygienic concern for the entirety of the city's terrain. While the Sulfurozador offered effective destruction of rats, it promised also a comprehensive - and utopian - disinfection of the whole city, freeing it from all imaginable pathogens, insects as well asrodents. In 1910, the successful introduction of the Sulfurozador encouraged Argentina's medico-political elite to introduce a new principle of 'general prophylaxis'. This article places the apparatus as a technological modernisation of traditional sanitary practices in the bacteriological age, which preserved the urban environment -'elterreno'- as a principal site of intervention. Thus, the Sulfurozador allowed the 'higienistas' to sustain a long-standing utopian vision of all-encompassing social, bodily and political hygiene into the twentieth century.

Analysis of Medical Errors: A Case Study

Analysis of Medical Errors: A Case Study

Confronting Hidden Threats to Sustainability. State of the World 2015. Project Directors: Gary Gardner, Tom Prugh, and Michael Renner. Washington (DC): Island Press. $19.99 (paper). xv + 165 p.; ill.; index. ISBN: 978-1-61091-610-3 (pb); 978-1-61091-611-0 (eb). 2015.

<i>Confronting Hidden Threats to Sustainability</i>. State of the World 2015. Project Directors: Gary Gardner, Tom Prugh, and Michael Renner. Washington (DC): Island Press. $19.99 (paper). xv + 165 p.; ill.; index. ISBN: 978-1-61091-610-3 (pb); 978-1-61091-611-0 (eb). 2015.