Hexylresorcinol Research Articles

Further researches on bactericidal mists and smokes

In Out original paper on germicidal aerosols (Twort, Baker, Finn & Powell, 1940) it was shown that the most satisfactory results were obtained with a solution of 10% hexyl resorcinol in propylene glycol together with a little alkali and wetting agent, the mixture being mechanically atomized into mist particles of appropriate size. Although it was confirmed by other workers that a high degree of lethal effectiveness on air-borne bacteria was achieved by the above procedure, objections were raised to its use in practice at the moment on the grounds that:(1) The germicide base was difficult to obtain.(2) The solvent was only manufactured in America, and not in bulk there.(3) The mechanical apparatus advocated involved the use of metals now required for the making of war weapons.

EFFECTS OF HEXYLRESORCINOL ON VALONIA

The effects on Valonia of guaiacol and hexylresorcinol are similar but the latter is more effective. Both substances lower or abolish the potassium effect; i.e., the ability of the cell to distinguish electrically between Na(+) and K(+). Both substances change the order of mobilities so that v(Cl) > u(Na) becomes u(Na) > v(Cl) or u(Na) = v(Cl).

The influence of germicides on the dehydrogenases ofBact. Coli: Part I. The succinic acid dehydrogenase ofBact. Coli

1. The effect of alcohols and of phenol on the succinic acid dehydrogenase ofBact. coli, hitherto recorded qualitatively in the literature, has been studied in greater detail.2. The effect of heat and ofp−chloro−m−cresol, hexyl resorcinol,p−butyl phenol and amyl−m−cresol, has also been studied.3. The concentrations of these germicides required to inhibit completely the succinic dehydrogenase is such as to allow for a slight excess over the concentrations which are lethal toBact. coli.

Effect of Certain Physical Factors on the In Vitro Testing of Anthelmintics.

Although certain investigators have done much to destroy confidence in the value of in vitro methods of testing anthelmintics by drawing too sweeping conclusions from uncontrolled experiments, these methods are of value and were used successfully by Lamson et al.1 in their studies on the alkyl resorcinols. These studies have resulted in the establishment of hexyl resorcinol as an effective as-caricide of relatively low toxicity. This method of in vitro testing of ascaricides is described elsewhere,2 but there remains for discussion certain physical factors which must be guarded against if reliable results are to be obtained.As Lo Monaco3 has already shown with santonin, an undissolved excess of the drug must be present in the testing solution for the best results, but he makes no mention of the effect of the physical state of the excess. However, a solid excess is far less effective than a liquid excess as will be shown. If certain substances, such as heptyl resorcinol, are allowed to stand for sometime i...

Enzymes in the Alimentary Canal of Mosquito Larvae

An attempt has been made to determine the presence of enzymes in the digestive tract of certain species of mosquito larvae. Phillips1 and Bertholf2 demonstrated the presence of enzymes in the honey-bee, both larvae and adults, by feeding them on solutions of chemically pure carbohydrates and comparing the length of life in contrast to controls fed on water alone. By this method they hoped to eliminate the interference of any enzyme from the tissues surrounding the gut, a difficult matter in isolation techniques. However these workers did not exclude microorganisms from the alimentary canal and it is conceivable that organisms hydrolysed the carbohydrates which were able to maintain the insects alive for considerable periods.The writer applied this method to culicid larvae and endeavored to exclude bacteria, etc., by sterilizing all media, either by auto-claving or filtering. Mosquito eggs disinfected in Hexyl Resorcinol (Hinman3) were introduced into solutions of chemically pure compounds, dissolved in a ...

The Rôle of Solutes and Colloids in the Nutrition of Anopheline Larvae

Summary 1. Hexyl resorcinol, in 1:1000 dilution in 30 parts glycerin and 70 parts water, has proven a satisfactory disinfectant for Culicid eggs provided they are immersed in the liquid for a period of two minutes. 2. Anopheline larvae are able to utilize material in solution and colloids in suspension from normal pool water. This has been demonstrated by the use of Seitz-Werke filtered media and the dialysable and non-dialysable fractions of water from breeding habitats. 3. Larvae of Anopheles crucians and A. quadrimaculatus are able to live up to a period of eleven days and to make significant growth, under sterile conditions, in Seitz-Werke filtered water. 4. These larvae are unable, however, to develop in the dialysate of water from the same breeding pools. 5. In the case of the non-dialysable fraction of the same type of water it has been found that the larvae may live up to six days and make a slight significant growth, indicating that the normal water colloids may be of considerable importance in the nutrition of anopheline larvae.

THE EFFECT OF PRESERVATIVES ON FERMENTATION BY SUGAR-TOLERANT YEASTS FROM HONEY

A study was made of the preservative effect of various compounds in an 80% honey solution inoculated with a mixed culture of honey-fermenting yeasts. Sodium hypochlorite and chloramine-T preparations did not prevent fermentation in the highest concentration used (100 p.p.m. available chlorine). Hydrogen peroxide, though effective in a 0.5% concentration, exerted a marked bleaching action in addition to affecting the taste. Hexyl resorcinol completely inhibited fermentation in 0.01% concentration. Complete preservation was not attained with sodium salicylate within the limits permissible in foodstuffs, 0.06% being required. The sodium salts of boric, benzoic and sulphurous acid tested, all prevented fermentation within the limits. Sodium benzoate, sodium sulphite and sodium bisulphite were considered the most promising, and appeared to merit further testing on a practical scale for the prevention of honey fermentation.

Experiments on the Effect of Di-hydranol on Intestinal Protozoa of Man and Laboratory Mammals.

Leonard and his associates (Leonard, Leonard and Frobisher, Hampil) have demonstrated the bactericidal properties of the acyl and alkyl derivatives of resorcinol and Ratcliffe has shown that the administration of certain of these derivatives to rats not only changes the intestinal flora from a Gram-positive to a Gram-negative type but also is effective in reducing the protozoa in the cecum (Trichomonas spp., Endamoeba muris). Trichomonads in young chicks were also killed on a one per cent N-heptyl resorcinol diet fed for 5 days (Ratcliffe, 1. c.). At the suggestion of Dr. Veader Leonard the writer has made a study of the effect of di-hydranol, a homolog of hexyl resorcinol, on certain intestinal protozoa of man and mammals in New Orleans. The drug has been prepared by Sharp and Dohme of Baltimore and been placed at the writer's disposal through the courtesy of Dr. Leonard. Structure and properties of di-hydranol. Di-hydranol (2-4-dihydroxy-phenyl n-heptane) is a yellowish crystalline product with the structural formula: Its taste is at first slightly sweetish, but soon there develops a definite mild acrid pungency, very similar to that of the root of the Indian turnip, Arisaema atrorubens, to be followed later by a mild numbness of the tongue. The drug is only slightly soluble in water. Hampil (1. c.) found the series to which this group belongs to be more bactericidal in alkaline solutions, presumably due to their greater solubility in this medium. In concentrated crystalline form it is too irritating for the human stomach but in olive oil, in which it is highly soluble, this difficulty is entirely obviated. Almost all of the drug is excreted by the bowel; its presence in the urine of a patient taking the drug in olive oil can be detected only by the most delicate technic. Its toxicity is clinically negligible.

Hexylresorcinol as General Antiseptic.

Hexylresorcinol as General Antiseptic.

THE EFFECT OF HEXYL RESORCINOL ON YEAST GROWTH AND FERMENTATION

Summary. Concentrations of 0.3 and 0.1 gm. of hexyl resorcinol per litre completely inhibit yeast growth and fermentation. Concentrations of 0.01 and 0.005 gm. only slightly inhibit. Invertase action is not affected in the presence of 0.3 gm. of hexyl resorcinol per litre of mash.

Hexyl Resorcinol in the Treatment of 50 Cases of Infections of the Urinary Tract

Hexyl Resorcinol in the Treatment of 50 Cases of Infections of the Urinary Tract

Hexyl Resorcinol. The Development and Clinical Application of a Synthetic Compound Possessing the Experimental Requirements of an Ideal Internal Urinary Antiseptic

Hexyl Resorcinol. The Development and Clinical Application of a Synthetic Compound Possessing the Experimental Requirements of an Ideal Internal Urinary Antiseptic