Heterodimeric Capsules Research Articles

Investigating Molecular Recognition by Mass Spectrometry: Characterization of Calixarene-Based Self-Assembling Capsule Hosts with Charged Guests

Capsules derived from the reversible assembly of calixarene tetraureas have been characterized by electrospray ionization mass spectrometry. Ion labeling was achieved through the encapsulation of ammonium ions as guest molecules. The gas-phase ion structure of the parent calixarene was determined by isotope pattern analysis, inclusion of labeled guests, and collision experiments. Competition experiments with different guest ions revealed a clear dependence of the encapsulation process on the size and shape of the guest ions. The formation of several different heterodimeric capsules, a covalently bridged capsule, and larger dumbbell-like aggregates containing two and three charged guests has been observed. The results parallel previous findings from NMR experiments in solution and thus support the validity of the MS method for characterization of these complexes in the gas phase.

Synthesis and Self-Assembly of Pseudo-Spherical Homo- and Heterodimeric Capsules

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Self-Assembly of Pseudo-Spherical Homo- and Heterodimeric CapsulesCarlos Valdes, Urs P. Spitz, Leticia M. Toledo, Stefan W. Kubik, and Julius Rebek Jr.Cite this: J. Am. Chem. Soc. 1995, 117, 51, 12733–12745Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://doi.org/10.1021/ja00156a010RIGHTS & PERMISSIONSArticle Views761Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts