Heterocyclic Organic Compounds Research Articles

THE INHIBITING EFFECT OF SOME HETEROCYCLIC AND OTHER ORGANIC COMPOUNDS ON TOBACCO MOSAIC VIRUS

A number of heterocyclic and miscellaneous organic compounds have been tested for their effectiveness as virus inhibitors by a half-leaf technique using Nicotiana glutinosa and tobacco mosaic virus. Several of these compounds were found to be effective in varying degrees, the main effects being a reduction in the total number of lesions produced, a delay in symptom expression, and a decrease in virus multiplication as indicated by small lesions, on the treated half-leaves. Although nothing is known about the mechanism of inhibition, it can be concluded that to effect inhibition compounds act through the physiology of the host, rather than directly on the virus. The virus content of treated half-leaves has been estimated by measuring their rate of oxygen consumption. These data indicate that the inhibiting compounds affect the metabolism of the host, as reflected in a change in respiration when compared to control half-leaves, and that the symptomless areas on the treated half-leaves do not contain significant concentrations of virus.

XII. The crystal structures of some heterocyclic organic compounds of analogous constitution.—Part III. Phenazine and diphenylene dioxide

Summary An account is given of crystallographic, optical, and X-ray measurements on phenazine and diphenylene dioxide. It is shown that the results for these substances imply that the phenazine molecule is plane, and are consistent with the molecule of diphenylene dioxide being plane. Our thanks are due to Dr. N. M. Cullinane, of the Chemistry Department of this College, who prepared the diphenylene dioxide; to Dr. E. E. Turner for specimens of phenazine; to Dr. E.G. Cox for access to some unpublished photographs of diphenylene dioxide; to Dr. Kathleen Lonsdale for unpublished magnetic measurements and for many valuable discussions; and to Professor R. T. Dunbar for his interest throughout the whole of the present work. One of us (G. W.) acknowledges the receipt of a University of Wales Postgraduate Studentship. A table summarizing the principal measurements on the eight crystals discussed in this series of papers is given above.

VI. The crystal structures of some heterocyclic organic compounds of analogous constitution.—Part I. Thianthren and selenanthren

(1941). VI. The crystal structures of some heterocyclic organic compounds of analogous constitution.—Part I. Thianthren and selenanthren. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 31, No. 204, pp. 62-70.