Introduction: Neck rejuvenation has a certain degree of difficulty, both due to its location and mobility, as well as its anatomical characteristics. Objective: To evaluate the efficacy and safety of intradermal microinjection of autologous platelet concentrate (APC) in the treatment of signs of neck aging. Method: An observational, analytical and longitudinal study was carried out in 60 patients from the Hospital Clínico Quirúrgico: “Hermanos Ameijeiras”, in the period between March 1, 2017 and March 31, 2020. The treatment was applied monthly for 1 year. The final evaluation was carried out 3 months after the end of the treatment. Results: 60 women with an average age of 45 ± 4.3 years were treated. After treatment, there were significant changes in the Glogau Photo Damage Scale (P = = 0.024), in the Global Aesthetic Improvement Scale (P <0.002) and in the Allergan Neck Transverse Lines Scale (P = 0.013). The adverse events found were pain, inflammation and ecchymosis. The degree of satisfaction reported by the patients was good (10.0%) and very good (90.0%) (P < 0.0012). Conclusions: The autologous platelet concentrate proved to be effective and safe to reduce the signs of aging in the neck, associated with a high degree of patient satisfaction.