Field small-plot experiments were carried out in the Moscow region, Rostov region and the Republic of Dagestan in 2021-2022. Herbicide Avrora, OD (100 g/l mesotrione + 80 g/l amicarbazone + 60 g/l nicosulfuron + 5 g/l aminopyralid) was studied during the two growing seasons. The high biological efficiency of Avrora, OD at the stage of 3-6 leaves of corn and the early growth stages of weeds was established. The optimal herbicide rates, the timing of protective measures, and the sensitivity of certain types of weeds were determined depending on the type of weed in crops to combat annual and perennial weeds. The increased application rate of the tested herbicide up to 1.0 l/ha led to an increase in the effectiveness of the pesticide in the number and weight of weeds and was 92.497.9 and 92.497.8 %, respectively. By the harvesting time, infestation of corn crops in the control decreased to 1617 plants/m2. In the variants with herbicides, infestation of crops did not exceed 8 plants/m2. High yields of green mass in the first zone and corn grains in the second and third soil-climatic zones were noted in all tested experimental variants. The use of Avrora herbicide in the early phases of weed growth on vegetative corn plants does not have a negative effect on crop plants and contributes to yield increases of up to 53.756.2 % when cultivating grain corn and up to 138.5 % when cultivating green mass corn.