Using the results of seventy‐one soybean (Glycine max) variety performance trials, the existence of a yield drag (YD) of herbicide‐resistant varieties when compared to conventional varieties is verified. The trials were conducted from 1996 to 2000 at five locations, on 569 varieties covering three maturity groups in irrigated and dryland conditions using conventional tillage. Trend analysis of YD suggests that it (i) is magnified by irrigation; (ii) has declined to negligible levels; (iii) is not significantly different across maturity group; and (iv) exhibits some locational differences. An analysis of six herbicide programs revealed that glyphosate programs are generally more expensive than reduced‐rate conventional programs but are comparable to or cheaper than full‐rate conventional herbicide regimes. It is further conjectured that seed/technology and herbicide cost differences across seed/herbicide systems will adjust to competitive conditions in the long run.