Event Abstract Back to Event Growth hormone (GH) acts on the GH/IGF-system in adult tilapia liver and immune organs Natallia Shved1*, Giorgi Berishvilia2, Jean-François Baroiller3, Peter Mazel2, Manfred Reinecke1 and Elisabeth Eppler2 1 University of Zürich, Division of Neuroendocrinology, Institute of Anatomy, Switzerland 2 University of Zürich, Institute of Anatomy, Switzerland 3 Campus International de Baillarguet, CIRAD-EMVT UPR20, Aquaculture Unit, France In mammals, the GH/IGF-I and the immune system have been shown to interact. The stimulatory significance of GH for the immune system is indicated by the presence of the GH-receptor (GHR) and insulin-like growth factor (IGF)-I. However, little is known on the local regulation of the IGFs and the GHR in immune organs. There is evidence for interactions also in bony fish since the GHR, IGF-I and IGF-II are also found in different fish species including the tilapia. Immune regulation is important for aquaculture and wild-life fish and thus plays an increasing role in basic science and aquaculture research. To investigate the local regulation of IGF-I, IGF-II and GHR by GH adult tilapia (Oreochromis niloticus) were challenged with intraperitoneal GH injections. The expression levels of hepatic GHR and IGF-I and IGF-I serum levels were quantified. Hepatic GHR mRNA was downregulated and IGF-I mRNA elevated as well as IGF-I serum levels in the GH-injected fish. IGF-I gene expression in spleen and head kidney was raised, in the latter even stronger than in liver. In the spleen, in addition to IGF-I also IGF-II mRNA was strongly elevated. Thus, head kidney and spleen reacted differently to GH treatment indicating different roles of GH and the IGFs in growth, differentiation and sustainment in the immune system of the tilapia. Whether this also has implications for immune response demands for further studies using bacteria and other pathogens. Supported by Swiss National Foundation (Project nos. 111028, 118165) and Hartmann Müller-Foundation for Medical Research (Project no. 1115). Keywords: comparative endocrinology Conference: 25th Conference of the European Comparative Endocrinologists, Pécs, Hungary, 31 Aug - 4 Sep, 2010. Presentation Type: Conference Presentation Topic: Comparative endocrinology Citation: Shved N, Berishvilia G, Baroiller J, Mazel P, Reinecke M and Eppler E (2010). Growth hormone (GH) acts on the GH/IGF-system in adult tilapia liver and immune organs. Front. Endocrinol. Conference Abstract: 25th Conference of the European Comparative Endocrinologists. doi: 10.3389/conf.fendo.2010.01.00004 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Aug 2010; Published Online: 29 Aug 2010. * Correspondence: Dr. Natallia Shved, University of Zürich, Division of Neuroendocrinology, Institute of Anatomy, Zürich, Switzerland, n.shved@anatom.uzh.ch Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Natallia Shved Giorgi Berishvilia Jean-François Baroiller Peter Mazel Manfred Reinecke Elisabeth Eppler Google Natallia Shved Giorgi Berishvilia Jean-François Baroiller Peter Mazel Manfred Reinecke Elisabeth Eppler Google Scholar Natallia Shved Giorgi Berishvilia Jean-François Baroiller Peter Mazel Manfred Reinecke Elisabeth Eppler PubMed Natallia Shved Giorgi Berishvilia Jean-François Baroiller Peter Mazel Manfred Reinecke Elisabeth Eppler Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.