Hepatic Enzyme Abnormalities Research Articles

Clindamycin-associated hepatotoxicity

Hepatotoxicity associated with intravenous clindamycin phosphate therapy is reported in a drug abuser cured of staphylococcal endocarditis. Coincident with the administration of large doses of clindamycin, marked hepatic enzyme abnormalities were noted, and liver biopsy showed lobular disruption, pseudogranulomas, hepatocyte necrosis, eosinophilic bodies and mononuclear cell infiltration. Cessation of clindamycin therapy resulted in return of liver enzymes to normal, and a second liver biopsy performed 15 days later showed improvement. Reports of clindamycin-associated hepatic enzyme changes are reviewed; further observation for clindamycin-associated hepatotoxicity is warranted.

Alterations of Alcohol Dehydrogenase and Other Hepatic Enzymes Following Oral Alcohol Intoxication

T lIE PURPOSE of this paper is to report hepatic enzyme abnormalities in adult rats subjected to chronic oral alcohol intoxication under conditions of controlled food intake. Reports in the literature demonstrate that alcohol seems to exert a direct toxic effect on >