ObjectiveTo investigate the imaging features of fungal liver infection in pediatric patients. Materials and methodsCT and MRI findings of fungal liver infection were retrospectively analyzed in nine pediatric patients. There were six males and three females, patients’ age ranged from 7 months to 9 years with an average of 4.1 years. ResultsOf the nine patients, one had a solitary lesion and eight had multiple lesions. According to the criteria based on the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC-MSG) guidelines for clinical research. Multiphasic CT and MRI examinations in the liver with fungal infection were performed and there were three types of imaging patterns. Type Ⅰ, "target-ring sign" phenomenon. The lesion showed uneven low or iso density on plain CT scan, uneven iso-T1 or long T1 and long T2 signal on MRI scan, and uneven annular enhancement on three-phases enhanced CT and MRI scan. Type Ⅱ, Delayed enhancement. The lesion showed low or iso-density on plain CT scan, in arterial phase and portal phase, and iso-density in delayed phase. Type Ⅲ, Delayed ring-like-enhancement. The lesion showed low or iso-density on plain CT scan, in arterial phase and portal phase, and ring-like enhancement in delayed phase. In arterial phase, the liver parenchyma around the lesion showed transient abnormal, hyperperfusion in seven patients. Usually the lesion did not affect the hepatic blood vessels which were seen in the enhanced scan. After antifungal therapy, the lesion decreased in size or even completely disappeared. ConclusionThe findings of fungal liver infection on CT and MRI exhibited some specific imaging patterns, which could be helpful for early diagnosis and treatment guidance.