Background and aims: Many recent studies suggest that postoperative hepatic artery-infusion chemotherapy (HAIC) in hepatocellular carcinoma(HCC) can effectively and safely reduce intrahepatic recurrence and improve the overall survival. In this study, we investigated 10 years follow-up of patients who underwent HAIC after curative resection of HCC. Materials and methods: We retrospectively reviewed medical records in last 10 years follow-up period of prospectively recruited HCC patients who underwent the adjuvant HAIC with 5-FU and cisplatin after curative resection of HCC. Total 128 patients were included and 31 patients underwent HAIC who were highly suspected recurrence in final pathologic report. Every 4 weeks, four cyscles of HAIC were given to patients in HAIC group. Results: . Platelet count and alpha-fetoprotein (AFP) levels HAIC group were higher than non-HAIC group in statistically. However MELD score was higher in non-HAIC group. Proportion of above T2 and portal vein, microvascular invasion in HAIC group were statistically different from non-HAIC group. There were no statistically differences between two groups regarding to not only overall survival (p value=0.568) but also disease-free survival (p value=0.975). Even after propensity score matching, there were no statistically significant differences in analysis of overall survival (p value=0.740) and disease-free survival (p- value=0.769). In subgroup analysis, especially above T2, HAIC group seems to be more favorable in overall survival, however there was no statistically significance between two groups (p value=0.512). Conclusion: In this study, we could not find any statistical oncologic benefit in long-term overall survival and disease-free survival in statistically.