Henry Le Research Articles

Sur les Lettres diverses d’Henry Le Bret, éditeur de Cyrano et prévôt de l’Église de Montauban

The Lettres diverses attributed to Henry Le Bret were published anonymously, without any date nor place of publication. This article deals with three problems : authorship, datation and Le Bret’s direct involvement in its publication.Le Bret’s paternity of Lettres diverses, included the only letter addressed to himself, is proven mainly by his signature found in many of them and by his attested private relationships with the majority of addressees. The publication date is resolved after a meticulous comparison of Lettres diverses and Recueil de quelques discours et lettres écrites à des personnes studieuses sur differentes matieres (1692), in which 15 letters (out of the 64 of Lettres diverses) are present with some variations. From an omission in the Recueil I theorized that a great number of pages from a published copy of Lettres diverses were detached/untied and reused as a material hypotext for the Recueil ; this theory is substantiated and confirmed by a lot of informations related to events, books, and people, especially to Bossuet, Queen Marie-Thérèse and the Clergy Assembly of 1665. All these data lead to the conclusion that Lettres diverses were published between 1678 and May 1681, which invalidates all previous datations proposed by Lacroix, Forestié, Cioranescu, and myself in 2004.And finally there is no historical evidence nor objective argument for believing that Le Bret did not want his readers to know that he was responsible for the publication of these letters : the book was obviously destined to a private and chosen group of friends, which was not uncommon in xviith century. In 1692, given his geographic and not so private new public, Le Bret withdrew from Lettres diverses all the ones addressed to his Parisian friends as well as some destined to Toulousan ladies in which good taste was questionable (like his Eloge de la petite vérole, i. e. small-pox).We can now reformulate the bibliographical description of this book : Lettres diverses par Henry Le Bret, prévôt de l’église cathédrale de Montauban, Montauban (?), ca 1678-1681.Among the addenda completing this article are a brief account of the controversy between Le Bret and the minister Pierre Isarn, a restitution of one of his remarks concerning Boileau’s Satire IX, and his quasi unknown éloge de la petite vérole.

Le Bret, Cuigy, Casteljaloux, Bignon, Royer de Prade et Regnault des Boisclairs : du nouveau sur quelques bons amis de Cyrano et sur l’édition posthume des États et Empires de la Lune (1657)

This article deals mainly with Henry Le Bret, Cyrano’s friend and editor. Only Le Bret’s Parisian years are concerned here, the ones which preceeded his clerical career in Montauban.Till now very little was known of Le Bret’s Parisian period and nothing at all of his career as a « avocat au Conseil Privé du Roi ». Long investigations in Archives Nationales (Paris, CARAN), mainly in notarial deeds (Minutier Central) and in Conseil Privé’s archives (series V6), as well as in Archives départementales de Tarn-et-Garonne (Montauban), allowed me to revive many of his friends and clients : in the second category can be found Bishop of Albi, Gaspard de Daillon du Lude, related to the Roquelaures, and to Cyrano through the wealthy Feydeau family ; in the first category appear many people named in Le Bret’s posthumous preface of Cyrano’s Etats et Empires de la Lune (1657), like the Cuigys, the Durets, Captain Carbon de Casteljaloux, the engraver Bignon and the dramatist and historian Royer de Prade. They were all living in a delimited area of the « Marais » (Right Bank : rues de la Verrerie, des Billettes, Sainte-Croix de la Bretonnerie, Simon Lefranc and Sainte-Avoye) ; even Cyrano’s protectors were there, Regnault des Boisclairs at rue de la Verrerie, and Duke of Arpajon, whose residence partly burnt in January 1655, at Vieille rue du Temple. A precious notarial deed reveals that Le Bret was a cleric before Cyrano died, situation which should bring a new light on the making of the posthumous edition, published with numerous cuts (« lacunes ») and variants ; another notarized document concerns the donation of Clamard « seigneurie » to Cuigy junior in 1656, donation which not only explains a variant of the posthumous edition but also provides an irrefutable evidence that Cyrano’s novel was altered after his death.Among the addenda completing this article are the autograph last will of Casteljaloux, written in 1642 in Clamard where he died in 1654, the donation of Clamard to Cuigy junior (1656) and a substantial repayment to Le Bret by Royer de Prade (1657) just before the former went to Montauban.

Abstract 5790: TG-1601 is a novel BET inhibitor with strong binding affinity and long-lasting effect in pre-clinical models

Abstract BET (bromodomain and extra-terminal) proteins bind to acetylated lysine residues on chromatin and participate in the regulation of gene transcription. Inhibition of BET protein binding to chromatin with small molecules selectively suppresses the transcription of a set of oncogenes, including MYC and BCL-2. TG-1601 is a novel, selective and potent small molecule inhibitor of BET bromodomains. TG-1601 binds to the first and second bromodomains (BD1, BD2) of the BET protein family, BRD2, BRD3, BRD4, and BRDT, with Kd values ranging from 0.5 nM to 9.1 nM. MYC protein expression is strongly inhibited in the MV4-11 cancer cell line with an EC50 of 5 nM, with GI50 comprised between 15 nM and 85 nM in a variety of leukemia and myeloma cancer cell lines, indicating potent inhibition of cell proliferation. Time course and dose-response studies conducted in mice bearing subcutaneous MV4-11 xenografts showed that MYC protein was undetectable 3 hours following a single 25 mg/kg oral dose, with a TG-1601 tumor concentration of 6uM achieved. Interestingly, at 24h post-dose, while TG-1601 is cleared from the tumor, MYC protein level remains below 40% of its initial level, indicating a long-lasting effect pharmacodynamic of TG-1601, potentially attributable to enhanced binding affinity compared to earlier generation molecules. In agreement with this long-lasting effect, efficacy studies in MV4-11 tumor-bearing mice, dosed with a 20 mg/kg/day PO regimen interrupted by increasing drug holiday periods, showed that drug holidays of 2, 3 and 4 days per week only modestly affected efficacy (3%, 15% and 12% TGI respectively), suggesting discontinuous dosing of TG-1601 in clinic may not significantly impact efficacy. Anti-cancer agents have been shown - in vitro or in vivo - to synergize with BET inhibitors. Here we show that TG-1601 and anti PD-1 antibody demonstrated synergistic anti-tumor activity when combined in the B16F10 model, an aggressive syngeneic model of melanoma. TG-1601 inhibition of MYC, CCR-2 and IL1RN gene expression was tested in a whole blood ex-vivo experiment, and the genes were validated as pharmacodynamic markers to monitor TG-1601 activity in clinic. In conclusion, TG-1601 is a novel BET inhibitor with remarkably strong affinity and a potent ability to inhibit MYC expression and cell growth, with favorable pharmacokinetic properties supporting clinical development. Its properties in vivo provide an opportunity for the rational development of TG-1601 as an anti-cancer agent, taken alone or in combination with other small molecules or antibodies. IND enabling studies are underway, with clinical evaluation expected to commence in the first half of 2018. Citation Format: Emmanuel Normant, Leonid Gorelik, Rama Shmeis, Henry Le, Robert Nisch, Karen TenHuisen, Teja Turpuseema, James Oliviero, Hari P. Miskin, Peter Sportelli, Michael S. Weiss. TG-1601 is a novel BET inhibitor with strong binding affinity and long-lasting effect in pre-clinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5790.

“Revue de Métallurgie” becomes “Metallurgical Research and Technology”

Fig. 1. Henry Le Chatelier. The journal Revue de Metallurgie was founded in 1904 by Henry Le Chatelier (Fig. 1), a famous chemist and metallurgist, representative of the great tradition of French metallurgy, as described in the interesting overview of the journal’s history, published on the occasion of its centenary in 2004 [1]. The founders, Henry Le Chatelier and Leon Guillet, devoted a large part of their time and competence to the launching of the Revue de Metallurgie. They obtained support from industrial companies and mainly from the Steel Industry (Le Comite des Forges at that time). The journal became a major tool for promoting the exchange of scientific and technical information among metallurgists and for speeding up the practical applications of research results from the lab to the plants. This industrial support was materialized by more than a thousand subscriptions for researchers and plant engineers. For more than 100 years, scientific methods, technical data, basic articles, and papers promoting new experiments, new processes and industrial improvements have been presented by a large number of famous metallurgists. Despite the exclusive use of the French language, the Revue de Metallurgie gained notable fame in Europe and in the world. During the years 1980−2008 the efficient synergy between the journal and the French Steel Federation (FFA), which organized the famous yearly “International Steelmaking Days” in Paris, contributed to its reputation. In the editorial by Jeanneau and Devillers published on the occasion of the journal’s centenary, the great lines for the future were featured: “... The use of English would be much appreciated, especially for the non-French-speaking societies... The future of the Revue should be determined by a strengthening of its international character, in connection with the research of synergies with other European journals and organizations1.” Since this anniversary, many changes have occurred, and the 2008 financial crisis impacted the journal with cost-cutting measures taken by its industrial supporters. In 2010 the Revue de Metallurgie became one of the scientific journals published by EDP Sciences. We successfully redefined the scope of the journal, extending the editorial line to nonferrous metals, and made possible its worldwide diffusion by publishing peer-reviewed papers mostly in English. Presently, the journal is better indexed in the main databases of the corresponding field. The time has come to take the next step: change to the English title “Metallurgical Research and Technology”. Of course, the previous name of our more

New light on the personal identification of a skeleton of a member of Sir John Franklin’s last expedition to the Arctic, 1845

In 1845, an expedition, commanded by Sir John Franklin, set out to try and discover the north-west passage. All 129 men on this ill-fated voyage perished. Over the years, skeletal remains associated with the final throes of the expedition have been located on and near King William Island, Nunavut, in the Canadian arctic. In general, even a tentative personal identification for these remains has proved impossible. An exception is some skeletal remains that were recovered in 1869 and brought back to England and interred beneath the memorial to the Franklin expedition in Greenwich. In the 19th century, these were tentatively identified as of one of HMS Erebus’s lieutenants, Henry Le Vesconte, a conclusion that has been widely accepted in studies of the Franklin voyage. Renovations to the monument in 2009 provided an opportunity for scientific examination of the remains, and to re-evaluate the personal identification made nearly 140 years before. The current work, which is the first modern scientific analysis of a fairly complete skeleton associated with the Franklin voyage, describes the remains and the artefacts interred with them, discusses the pathological conditions present, and evaluates the personal identification using osteological techniques and isotope geochemistry. Results indicate that the remains are of an adult male of European ancestry. Although some writers have suggested that scurvy or tuberculosis may have been important causes of morbidity and mortality on the Franklin expedition, osteological analysis and, in the case of tuberculosis, DNA analysis, provided no evidence for their presence in these remains. Isotopic studies indicate that the personal identification as Le Vesconte is unlikely to be correct. From the isotopic results and forensic facial reconstruction, HDS Goodsir, an assistant surgeon on the expedition, appears a more likely identification, but the results do not allow a firm conclusion.

Vive la Chimie

Vive la Chimie

La Revue de Métallurgie: a centennial history

La Revue de Metallurgie is forever associated with the name of the great French Scientist who created it in 1904: Henry Le Chatelier. On the occasion of the centenary of the Revue, the authors draw an overview of its history that is intimately linked with the one of Metallurgy. More recently, la Revue de Metallurgie has been able to evolve permanently with a view to afford a better service to its readers. Other French journals have merged with the Revue and an electronic version has been introduced in 2000 as a tribute to the new century. Nevertheless other circumstances must now be allowed for, in an ever more global World with new European industrial groups and universities or engineering schools ever more focused on the international. From now on, Industry and Science, the preferred couple of Henry Le Chatelier, must be considered on a European basis. This shows the way for la Revue de Metallurgie in the Future.

Monitoring Cement Quality By Microscopy

Abstract In the late 19th century Henry Le Chatelier was perhaps the first to appreciate that chemical analysis revealed little concerning the nature of the compounds formed during the fusion and crystallization of cement. He was the first to apply the microscope consistently to this problem and recorded numerous microscopic observations made from thin sections of cement and the various crystal forms. A.E. Thornebohm, at about the same time, was also using the microscope to study crystals in cement. He assigned the names alite, belite, celite and felite to these crystal forms. The term alite is still used today as the name for the angular tricalcium silicate crystal (C3S) and belite is still commonly used as the name for the spherical dicalcium silicate crystals (C2S). The chemical compounds found in Portland cement are identified within the cement industry using the unique symbols shown in this article. Other pioneers in early cement microscopy were Stern and Wetzel who worked with polished section techniques, also Tevasci who developed several chemical etchants. Improvements in qualitative methods were given by Insley, Flint, Newman and Swenson. Methodology Microscopic examination of dry cement samples has led to better oil well cement job performance through more accurate job design and rejection of poor quality and contaminated cement. It may also indicate whether selected additives have actually been added to the mix. Two methods, each of which require microscopes with 100x to 400x power, are used in the preparation and examination of samples.Examination of neat cement (pure cement without additives and before mixing with water) is accomplished by following the techniques described by Bogue in the late 1940s. A sample of neat cement is mounted in an epoxy binder on a glass slide, then polished by a series of pastes containing progressively finer abrasives. The sample is then chemically etched to highlight the colours. A variety of filters may be added to the microscope to cause cement crystals and contaminants to show up in distinguishing colours. This is the principal method used for examination of cement quality because colours that indicate quality show up vividly in the opaque sample when using a reflected light for illumination (Figs. I, 3, 5 and 6). Transmitted, polarized light may also be used if the sample is thin enough to be translucent (Figs. 3 and 4).Identification of additives and contaminants is achieved by mounting a sample of dry cement on a clear slide and illuminating it with polarized light generated from below. No particular preparation of the sample is necessary (Figs. 7 through 12). This method does not always show vivid colours, thus the illustrations are in black and white. Particle shapes and sizes key the identification of additives and contaminants seen by transmitted, polarized light shining through the samples. Quality of Cement Cement microscopy visually reveals some deficiencies that may have existed in the manufacturing process. Microscopic examination may reveal the following qualities referenced to API Spec. 10.

REPLY TO HENRY LE ROY FINCH

Philosophical InvestigationsVolume 4, Issue 3 p. 78-81 REPLY TO HENRY LE ROY FINCH JOHN W. COOK, JOHN W. COOK 718 MISSION CANYON ROAD SANTA BARBARA, CALIFORNIA 93105Search for more papers by this author JOHN W. COOK, JOHN W. COOK 718 MISSION CANYON ROAD SANTA BARBARA, CALIFORNIA 93105Search for more papers by this author First published: July 1981 https://doi.org/10.1111/j.1467-9205.1981.tb00242.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume4, Issue3July 1981Pages 78-81 RelatedInformation

"Wittgenstein—The Later Philosophy: An Exposition of the Philosophical Investigations," by Henry Le Roy Finch

"Wittgenstein—The Later Philosophy: An Exposition of the Philosophical Investigations," by Henry Le Roy Finch

テイラーシステムとフランス産業

Shop Management, one of the most important works of F.W. Taylor, was translated into French by Henry Le Chatelier in 1907. The Principles of Scientific Management was also translated into French in 1912.The French business circles were so much interested in this new system of labour management that French scholars wrote many articles on this subject. Charles Fremont, for example, showed in his article of 1913 the origin of chronometry in France. According to him, it was in 1688 that the chronometry was already applied in the military work in France for the first time. He wanted to show French originality in chronometry.On the other hand, trade union leaders protested violently against the application. of this new system to French industries, so that the Taylor System was not easily accepted by French laborers.According to H. Le Chatelier, the application of Taylor System failed in France because the French society lacked the common sense (Le Bons Sens) which prevailed in U.S.A.

"Wittgenstein—The Early Philosophy: An Exposition of the "Tractatus,'" by Henry Le Roy Finch

"Wittgenstein—The Early Philosophy: An Exposition of the "Tractatus,'" by Henry Le Roy Finch

Henry Louis Le Chatelier, 1850 - 1936

Henry Louis Le Chatelier, whose death occurred on 17 September, 1936, at Miribel-les-Echelles (Ise"re), was born in Paris on 8 October, 1850. His father, Louis Le Chatelier, was closely associated as an engineer with the construction of the railways of France, Northern Spain, and Southern Austria, with the development of the Siemens-Martin process of steel making, with the production of aluminium, and with other important steps in the evolution of French industry. Both he and his wife came from families which included many names associated with the sciences and the arts. Henry was the eldest of six children, of whom Louis became a director of blast furnaces, Andre a metallurgist of note, and Alfred professor of Mussulman Sociology in the College de France, and one of the inspirers of French policy in Northern Africa. After his schooling at the College Rollin, which he always recalled with pleasure, Henry Le Chatelier entered the Ecole Polytechnique in 1869, and while still a student took part as a sub-lieutenant in the defence of Paris, passing in 1871 to the Ecole des Mines. In the course of the celebration of his scientific jubilee at the Sorbonne in 1922 he gave some reminiscences of his student days, and spoke of the influence of his father and of his professors in inculcating a love of the experimental method and a distrust of purely verbal explanations and of mathematical reasoning claiming to override experimental results. This attitude remained with him to the end.

III.—Two Forfeitures in the Year of Agincourt

The two forfeitures here described have no more certain connexion than that they both took place in the same year, and that the chief documents for both now lie together in the same file. The first has to do with the property of Henry le Scrope, who was the prime mover in the plot against Henry Vand was executed at Southampton on 5th August 1415. The second has to do with Richard Gurmyn, a Lollard who was burnt at Smithfield for heresy on 9th September in the same year. It is possible that the Lollard leader, Sir John Oldcastle, was privy to Scrope's plot, and it is not impossible that Gurmyn's execution was in part political; but even if Gurmyn was in any way concerned in Scrope's plot, the connexion between the forfeitures is purely accidental.

Societies and Academies

PARIS. Academy of Sciences, September 27.—M. Ed. Perrier in the chair.—Paul Appell: A second form of Θ functions of the fourth degree.—Henry Le Chatelier and Jules Lemoine: The heterogeneity of steels. An account of the application of an etching reagent proposed by Stead (methyl alcoholic solution of cupric and magnesium chlorides containing hydrochloric acid), with details of the proportions found to give the best results. Nine reproductions of microphotographs accompany the paper.—J. Haag: A system of differential formulae concerning the elements of a projectile submitted to a quadratic resistance of air.—Charles Rabut: The calculation of the strength of a beam reinforced with metal bands.—P. Vaillant: The laws of flow of liquids in drops. The weight of a drop from a given orifice depends on the number of drops per second. It is proved that the weight of a drop is a parabolic function of the frequency of fall, and experimental data are given in support of this.—P. W. Stuart Menteath: The Permian of the western Pyrenees.—Jules Welsch: The Pliocene lignites of Bidart, Lower Pyrenees. South of Biarritz there are deposits of lignite the age of which is near to the Middle Pliocene.—R. Chudeau: Rain and vapour pressure in western and equatorial Africa.—J. Bergonié: A new method of physical treatment of the after results of wounds: pneumatic pulsatory massage, A detailed description of the mode of application of mechanical massage to the treatment of masses of cicatricial tissue. Particulars of the results obtained will be published later.—P. Portier: The resistance of certain races of B. subtilis arising from insects to chemical reagents. The organisms, isolated from the larva of Tenebrio molitor and the chrysalis of Myeloïs cribrella, prove to survive very drastic treatment, including 50 hours with 5 per cent, phenol, 25 hours with 20 per cent, formaldehyde, 95 per cent, alcohol more than fourteen months, boiling chloroform, and other reagents. This resistance to chemical reagents is greater than any hitherto observed, and has a direct bearing on the problem of sterilisation of instruments and bandages.—J. Wolff and Mile. Nadia Rouchelmann: The properties of a chromogen universally distributed in plants.—A. de la Baume Pluvinel: The use of Hughes's induction balance for the detection of projectiles in the wounded.

Societies and academies

Societies and academies

Societies and Academies

Societies and Academies

7. Henry le Keu and Agnes his wife v. John de Chester

7. Henry le Keu and Agnes his wife <i>v.</i> John de Chester